16346-1-AP

antibody from Proteintech Group

Targeting: AGER RAGE, SCARJ1

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

16346-1-AP

Provider

Proteintech Group

Product name

AGER antibody

Antibody type

Polyclonal

Description

AGER antibody (Cat. #16346-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

HMGB1 Modulates High Glucose-Induced Erroneous Differentiation of Tendon Stem/Progenitor Cells through RAGE/β-Catenin Pathway.

Lu P, Dai G, Shi L, Li Y, Zhang M, Wang H, Rui Y
Stem cells international 2024;2024:2335270

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Astrocyte-derived CHI3L1 signaling impairs neurogenesis and cognition in the demyelinated hippocampus.

Song Y, Jiang W, Afridi SK, Wang T, Zhu F, Xu H, Nazir FH, Liu C, Wang Y, Long Y, Huang YA, Qiu W, Tang C
Cell reports 2024 May 28;43(5):114226

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Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop.

Yang S, Xie J, Pan Z, Guan H, Tu Y, Ye Y, Huang S, Fu S, Li K, Huang Z, Li X, Shi Z, Li L, Zhang Y
Experimental & molecular medicine 2024 Mar;56(3):630-645

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Fei-Yan-Qing-Hua decoction decreases hyperinflammation by inhibiting HMGB1/RAGE signaling and promotes bacterial phagocytosis in the treatment of sepsis.

Zhang H, Xu G, Wu X, Xu Y, Xu L, Zou Y, Yang X, Pan L, Lei B, Mu J, Huang Q, Ma Y, Duan N, Zhang W, Zheng Y
Journal of ethnopharmacology 2024 Mar 1;321:117553

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Maternal obstructive sleep apnea aggravates metabolic dysfunction-associated fatty liver disease via HMGB1-TLR4 signaling-mediated endoplasmic reticulum stress in male offspring rats.

Wang R, Feng W, Wang Y, Jiang Y, Lin Y, Chen X
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166889

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Protective effect of heat-processed Gynostemma pentaphyllum on high fat diet-induced glucose metabolic disorders mice.

Xie JB, Xie P, Guo M, Li FF, Xiao MY, Qi YS, Pei WJ, Luo HT, Gu YL, Piao XL
Frontiers in pharmacology 2023;14:1215150

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Macrophage RAGE deficiency prevents myocardial fibrosis by repressing autophagy-mediated macrophage alternative activation.

He J, Wei L, Tan S, Liang B, Liu J, Lu L, Wang T, Wang J, Huang Y, Chen Z, Li H, Zhang L, Zhou Z, Cao Y, Ye X, Yang Z, Xian S, Wang L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Nov;37(11):e23259

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Advanced Glycation End Products and Bone Metabolism in Patients with Chronic Kidney Disease.

Quadros KRS, Roza NAV, França RA, Esteves ABA, Barreto J, Dominguez WV, Furukawa LNS, Caramori JT, Sposito AC, de Oliveira RB
JBMR plus 2023 Mar;7(3):e10727

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RAGE signaling pathway is involved in CUS-induced depression-like behaviors by regulating the expression of NR2A and NR2B in rat hippocampus DG.

Zhang L, Luo L, Xue L, Ran D, Yang F, Tang Q, Jiang W
Experimental neurology 2023 Mar;361:114299

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Pterostilbene could alleviate diabetic cognitive impairment by suppressing TLR4/NF-кB pathway through microbiota-gut-brain axis.

Zhang ZT, Deng SM, Chen C, He QH, Peng XW, Liang QF, Zhuang GD, Wang SM, Tang D
Phytotherapy research : PTR 2023 Aug;37(8):3522-3542

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AGEs promote atherosclerosis by increasing LDL transcytosis across endothelial cells via RAGE/NF-κB/Caveolin-1 pathway.

Shu M, Cheng W, Jia X, Bai X, Zhao Y, Lu Y, Zhu L, Zhu Y, Wang L, Shu Y, Song Y, Jin S
Molecular medicine (Cambridge, Mass.) 2023 Aug 21;29(1):113

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Glycyrrhizin regulates rat TMJOA progression by inhibiting the HMGB1-RAGE/TLR4-NF-κB/AKT pathway.

Hu Z, Xiao M, Cai H, Li W, Fang W, Long X
Journal of cellular and molecular medicine 2022 Feb;26(3):925-936

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NAG-1/GDF15 inhibits diabetic nephropathy via inhibiting AGE/RAGE-mediated inflammation signaling pathways in C57BL/6 mice and HK-2 cells.

Chen J, Peng H, Chen C, Wang Y, Sang T, Cai Z, Zhao Q, Chen S, Lin X, Eling T, Wang X
Life sciences 2022 Dec 15;311(Pt A):121142

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Harm of circadian misalignment to the hearts of the adolescent wistar rats.

Wang Y, Hou Y, Song S, Zuo Y, Yu Y, Chi Y, Zhang T
Journal of translational medicine 2022 Aug 6;20(1):352

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Roles of RAGE/ROCK1 Pathway in HMGB1-Induced Early Changes in Barrier Permeability of Human Pulmonary Microvascular Endothelial Cell.

Zhao MJ, Jiang HR, Sun JW, Wang ZA, Hu B, Zhu CR, Yin XH, Chen MM, Ma XC, Zhao WD, Luan ZG
Frontiers in immunology 2021;12:697071

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Proof-of-concept study investigating the role of S100P-RAGE in nasopharyngeal carcinoma.

Wang C, Wang X, Han A, Wang Y, Jiang H
Experimental and therapeutic medicine 2021 May;21(5):470

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HMGB1 signaling-regulated endoplasmic reticulum stress mediates intestinal ischemia/reperfusion-induced acute renal damage.

Lai HJ, Zhan YQ, Qiu YX, Ling YH, Zhang XY, Chang ZN, Zhang YN, Liu ZM, Wen SH
Surgery 2021 Jul;170(1):239-248

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Celastrol exerts a neuroprotective effect by directly binding to HMGB1 protein in cerebral ischemia-reperfusion.

Liu DD, Luo P, Gu L, Zhang Q, Gao P, Zhu Y, Chen X, Guo Q, Zhang J, Ma N, Wang J
Journal of neuroinflammation 2021 Aug 9;18(1):174

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An integrated network pharmacology and transcriptomic method to explore the mechanism of the total Rhizoma Coptidis alkaloids in improving diabetic nephropathy.

Xiao Y, Liu Y, Lai Z, Huang J, Li C, Zhang Y, Gong X, Deng J, Ye X, Li X
Journal of ethnopharmacology 2021 Apr 24;270:113806

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Neuroprotective Effects of Celastrol on Transient Global Cerebral Ischemia Rats via Regulating HMGB1/NF-κB Signaling Pathway.

Zhang B, Zhong Q, Chen X, Wu X, Sha R, Song G, Zhang C, Chen X
Frontiers in neuroscience 2020;14:847

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Aucubin Attenuates Liver Ischemia-Reperfusion Injury by Inhibiting the HMGB1/TLR-4/NF-κB Signaling Pathway, Oxidative Stress, and Apoptosis.

Zhang S, Feng Z, Gao W, Duan Y, Fan G, Geng X, Wu B, Li K, Liu K, Peng C
Frontiers in pharmacology 2020;11:544124

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RAGE Signaling pathway in hippocampus dentate gyrus involved in GLT-1 decrease induced by chronic unpredictable stress in rats.

Yang F, Wang H, Chen H, Ran D, Tang Q, Weng P, Sun Y, Jiang W
Brain research bulletin 2020 Oct;163:49-56

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Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages/microglia polarization and affords neuroprotection after spinal cord injury.

Fan H, Tang HB, Chen Z, Wang HQ, Zhang L, Jiang Y, Li T, Yang CF, Wang XY, Li X, Wu SX, Zhang GL
Journal of neuroinflammation 2020 Oct 9;17(1):295

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AGEs-RAGE axis causes endothelial-to-mesenchymal transition in early calcific aortic valve disease via TGF-β1 and BMPR2 signaling.

Deng G, Zhang L, Wang C, Wang S, Xu J, Dong J, Kang Q, Zhai X, Zhao Y, Shan Z
Experimental gerontology 2020 Nov;141:111088

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HMGB1 mediates homocysteine-induced endothelial cells pyroptosis via cathepsin V-dependent pathway.

Leng Y, Chen R, Chen R, He S, Shi X, Zhou X, Zhang Z, Chen AF
Biochemical and biophysical research communications 2020 Nov 19;532(4):640-646

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HMGB1-associated necroptosis and Kupffer cells M1 polarization underlies remote liver injury induced by intestinal ischemia/reperfusion in rats.

Wen S, Li X, Ling Y, Chen S, Deng Q, Yang L, Li Y, Shen J, Qiu Y, Zhan Y, Lai H, Zhang X, Ke Z, Huang W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Mar;34(3):4384-4402

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IL-12p40 and sRAGE in serum correlate with chemically induced cleft palate in mice.

Wang XH, Peng Y, Meng LY
Human & experimental toxicology 2020 Dec;39(12):1661-1670

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HMGB1 Mediates Paraquat-Induced Neuroinflammatory Responses via Activating RAGE Signaling Pathway.

Huang M, Guo M, Wang K, Wu K, Li Y, Tian T, Wang Y, Yan W, Zhou Z, Yang H
Neurotoxicity research 2020 Apr;37(4):913-925

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Aqueous extracts of se-enriched Auricularia auricular attenuates D-galactose-induced cognitive deficits, oxidative stress and neuroinflammation via suppressing RAGE/MAPK/NF-κB pathway.

Wang J, Zhang T, Liu X, Fan H, Wei C
Neuroscience letters 2019 Jun 21;704:106-111

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Sialic Acid-Functionalized PEG-PLGA Microspheres Loading Mitochondrial-Targeting-Modified Curcumin for Acute Lung Injury Therapy.

Jin F, Liu D, Yu H, Qi J, You Y, Xu X, Kang X, Wang X, Lu K, Ying X, You J, Du Y, Ji J
Molecular pharmaceutics 2019 Jan 7;16(1):71-85

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Pro-inflammatory role of high-mobility group box-1 on brain mast cells via the RAGE/NF-κB pathway.

Qian QQ, Zhang X, Wang YW, Xu JW, Dong HQ, Li NN, Qian YN, Gui B
Journal of neurochemistry 2019 Dec;151(5):595-607

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High glucose-induced complement component 3 up-regulation via RAGE-p38MAPK-NF-κB signalling in astrocytes: In vivo and in vitro studies.

Zhao Y, Luo C, Chen J, Sun Y, Pu D, Lv A, Zhu S, Wu J, Wang M, Zhou J, Liao Z, Zhao K, Xiao Q
Journal of cellular and molecular medicine 2018 Dec;22(12):6087-6098

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Heparanase-driven inflammation from the AGEs-stimulated macrophages changes the functions of glomerular endothelial cells.

Xu G, Qin Q, Yang M, Qiao Z, Gu Y, Niu J
Diabetes research and clinical practice 2017 Feb;124:30-40

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Lower concentrations of receptor for advanced glycation end products and epiregulin in amniotic fluid correlate to chemically induced cleft palate in mice.

Wang X, Zhu J, Fang Y, Bian Z, Meng L
Environmental toxicology and pharmacology 2017 Apr;51:45-50

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

mouse lung tissue were subjected to SDS PAGE followed by western blot with 16346-1-AP( AGER Antibody) at dilution of 1:600

Other comments

WB

Appendix

16346-1-AP.pdf

Show more

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemistry of paraffin-embedded human renal cell carcinoma tissue slide using 16346-1-AP( AGER Antibody) at dilution of 1:50 (under 10x lens)

Other comments

IHC

Appendix

16346-1-AP.pdf

Show more