16346-1-AP

antibody from Proteintech Group

Targeting: AGER RAGE, SCARJ1

Provider product page for 16346-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [71]
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Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 16346-1-AP - Provider product page
Provider: Proteintech Group
Product name: AGER antibody
Antibody type: Polyclonal
Description: AGER antibody (Cat. #16346-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

AGER protein structure - 16346-1-AP shown in red.

Submitted references Network Pharmacology Combined With Gut Microbiome and Serum Metabolomics Reveals the Therapeutic Mechanisms of Hydroxysafflor Yellow A in Diabetic Kidney Disease.

Wang P, Liu X, Sun W, Dong X, Tan J, Chen M, He J, Ali A, Wu L, Shao K
Journal of diabetes research 2026;2026(1):e2131566

Taohong siwu decoction alleviates hand-foot skin reaction by regulating RAGE-mediated keratinocyte apoptosis and autophagy.

Dong H, Liu Z, Yu F, Li J, Zheng Y, Shen Y, Wang A, Wu D, Wang X, Cui H, Peng Y
Journal of ethnopharmacology 2026 May 23;363:121401

Expression of proteins secreted by osteocytes in bone biopsies of patients with chronic kidney disease and iron overload, before and after treatment with deferoxamine.

Machado HKAG, Dos Reis LM, Nunes LA, Oliveira IB, Silva C, Dominguez WV, Elias RM, Moysés RM, Custódio M, Jorgetti V
Bone 2026 Mar;204:117754

Bu-Shen-Tian-Jing Formula alleviates oxidative-inflammatory stress in granulosa cells of polycystic ovary syndrome through AGEs-RAGE/NOX4/NF-κB pathway.

Zhang Q, Ren J, Ye J, Chen F, Xiang F, Shi B, Zhou Z, Zhou J, Wang F, Qu F
Chinese medicine 2026 Jan 23;21(1):50

Targeting microglial inflammation in Parkinson's disease: irisin activates PAFAH1B1-RAGE ubiquitination and TFEB-dependent autophagy to alleviate neurodegeneration.

Cai L, Liu Y, Tang S, Deng S, Zhang L, Wang Y, Zhang B, Han B, Xie R, Liao X, Yang Q
Communications biology 2026 Jan 10;9(1):114

Diagnostic and therapeutic potential of PCSK9 in diabetic tubulopathy: Evidence from observational and experimental studies.

Quan J, Li S, Yi B, Huang Z
International immunopharmacology 2026 Jan 1;168(Pt 2):115907

Novel Glycyrrhizinic Acid Derivative YCY-20 Inhibits Cerebral Ischemia/Reperfusion Induced Apoptosis via the AGE-RAGE/MAPK Pathway.

Luo J, Qin X, Chen J, Yu X, Liu Z, Lv J, Pan X, Chen Y, Wei L
CNS neuroscience & therapeutics 2026 Feb;32(2):e70792

Inducible CD147 up-regulation boosts extended SARS-CoV-2 infection triggering severe COVID-19 independent of ACE2.

Wang K, Lin P, Chen R, Huang Q, Zhao Y, Zhang L, Zhao Y, Zhong L, Xu K, Bao L, Wang Y, Qin C, Wu G, Zhang H, Geng J, Zhang Z, Wei D, Chen X, Tang H, Yang L, Yang X, Sun X, Yao R, Zhao Y, Qin W, Yang Z, Chen L, Bian H, Chen ZN, Zhu P
Signal transduction and targeted therapy 2026 Feb 3;11(1):42

Neutrophil extracellular traps promote epithelial-mesenchymal transition in COPD via the RAGE/PI3K/AKT pathway.

Zou J, Chen L, Yang Y, Huo Z, Liu Y, Luo Z, Ou S, Xu C, Bai J
Experimental cell research 2026 Feb 15;455(2):114869

Ethyl Acetate Extract of Elsholtzia bodinieri Vaniot Attenuates Oxidative Stress in ALI Mice.

Yin H, Hu J, Li Y, Feng Y, Li Z, Sun R, Tian L, Li Y
Journal of inflammation research 2025;18:7323-7336

Fu-Fang-Qi-Di-Hua-Yu-Tang Improves Diabetic Macrovascular Disease via PI3K/AKT Pathway Regulation.

Zhang S, Yan M, Liang P, Zhang Y, Liu J, Huang H, Li G, Wu H
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:2247-2265

Catalpol Alleviates HFpEF via Inhibition of the S100A8-RAGE-NOX4 Inflammatory Axis in Murine Hearts.

Cao Y, Li S, Zhang Y, He M, Shen Y
Journal of inflammation research 2025;18:17143-17161

Soluble urokinase plasminogen activator receptor promotes endoplasmic reticulum stress and apoptosis susceptibility through RAGE in sepsis acute kidney injury.

Wang B, Wang J, Qi C, Gao C, Wang Y, Zan Y, Tan Y, Wu Z, Jiang J, Suo J, Zhang J, Peng Z
Molecular medicine (Cambridge, Mass.) 2025 Sep 26;31(1):296

Epalrestat, an aldose reductase inhibitor, mitigates doxorubicin-induced cardiotoxicity by inhibiting glycometabolism.

Zhu J, Wang H, Guan Y, Wang Y, Tan W, Wang J
International immunopharmacology 2025 Sep 23;162:115106

Dual-targeting antioxidant and anti-glycation strategy inhibits melanogenesis through clinical and mechanistic study.

Ye Y, Mu J, Lin S, Zhang T, Ye F, Wang Y, Xuan L, Chen C, Yang P, Wang J, Huang H
Scientific reports 2025 Oct 9;15(1):35226

Nanozyme Cryogel Accelerates Diabetic Wound Healing by Targeting Biofilms and Inflammations of the Wound Bed.

Shen Z, Du L, Fang X, Zhang Z, Li X, Xiao S, Xiao J, Chen S
ACS nano 2025 Oct 7;19(39):35081-35101

Panax ginseng alleviates diabetic peripheral neuropathy by suppressing mitochondrial dysfunction and oxidative stress via modulation of the RAGE, NF-κB, and Nrf2 pathways.

Liu P, Yang T, Zhang J, Su B, Shi Q, Song Y, Yu X
Journal of ginseng research 2025 Nov;49(6):734-745

Aβ impairs bone vascular homeostasis in APP/PS1 mice via disrupting the mitochondrial fission-efferocytosis axis in macrophages.

Liu T, Zhang W, Bao W, Wang X, Zhang F, Guo J, Li M
International immunopharmacology 2025 Nov 14;165:115526

RAGE/AP-1/OTR signaling pathway in rat hippocampus DG involved in CUS induced depressive-like behaviors.

Li X, Wang X, Xue L, Luo L, Hu L, Jiang W
Behavioural brain research 2025 May 8;485:115540

Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae.

Wei X, Qian W, Narasimhan H, Chan T, Liu X, Arish M, Young S, Li C, Cheon IS, Yu Q, Almeida-Santos G, Zhao XY, Yeatts EV, Spear OJ, Yi M, Parimon T, Fang Y, Hahn YS, Bullock TNJ, Somerville LA, Kaplan MH, Sperling AI, Shim YM, Vassallo R, Chen P, Ewald SE, Roden AC, Que J, Jiang D, Sun J
Science (New York, N.Y.) 2025 Mar 7;387(6738):eadq2509

Inhibiting HMGB1/AGER/NF-κB pathway prevents pro-inflammatory microglia polarization and protect photoreceptors in retinitis pigmentosa.

Hu C, Cui T, Xu Z, Yang K, Wu Y, Cai W, Yu J, Qiu Y
International immunopharmacology 2025 Mar 6;149:114192

Cross-species tropism of AAV.CPP.16 in the respiratory tract and its gene therapies against pulmonary fibrosis and viral infection.

Yang Z, Yao Y, Chen X, Madigan V, Pu S, Fan X, Pu J, Bei F
Cell reports. Medicine 2025 Jun 17;6(6):102144

Network pharmacology, molecular docking, and experimental verification to reveal the mechanism of colquhounia root tablet in the treatment of diabetic nephropathy.

Chen D, Wang S, Sun Z, Zhang X, Chong N, Shu J, Wang Q, Xu Y
Biochemical and biophysical research communications 2025 Jan;745:151086

Repeated low-intensity noise exposure exacerbates age-related hearing loss via RAGE signaling pathway.

Sun J, Sai N, Zhang T, Tang C, Fan S, Wang Q, Liu D, Zeng X, Li J, Guo W, Yang S, Han W
Neurobiology of disease 2025 Jan;204:106768

S100P is a ferroptosis suppressor to facilitate hepatocellular carcinoma development by rewiring lipid metabolism.

Yang M, Cui W, Lv X, Xiong G, Sun C, Xuan H, Ma W, Cui X, Cheng Y, Han L, Chu B
Nature communications 2025 Jan 8;16(1):509

Huang-Lian-Jie-Du Decoction alleviates diabetic encephalopathy by regulating inflammation and pyroptosis via suppression of AGEs/RAGE/NF-κB pathways.

Zhuang GD, Deng SM, Chen MD, Deng CF, Gu WT, Wang SM, Tang D
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118787

Migrasomes derived from human umbilical cord mesenchymal stem cells: a new therapeutic agent for ovalbumin-induced asthma in mice.

Gu W, Zheng T, Li W, Luo X, Xu X, Wang Y, Mao C, Ma Y, Dong L
Stem cell research & therapy 2025 Jan 26;16(1):26

A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease.

Lim K, Rutherford EN, Delpiano L, He P, Lin W, Sun D, Van den Boomen DJH, Edgar JR, Bang JH, Predeus A, Teichmann SA, Marioni JC, Matesic LE, Lee JH, Lehner PJ, Marciniak SJ, Rawlins EL, Dickens JA
The EMBO journal 2025 Feb;44(3):639-664

RAGE-mediated intestinal pro-inflammatory responses triggered by Giardia duodenalis.

Li L, Yao Y, Cao L, Le Y, Li X, Wang X, Zhang X, Li J, Zhang N, Jiang W, Gong P
Acta tropica 2025 Feb;262:107529

Carnosol exerts anti-inflammatory effects in pulpitis by inhibiting the RAGE/NF-κB signalling pathway.

Liu X, Zhao C, Zong X, Fang W, Zhang J, He W, Li W
Scientific reports 2025 Dec 29;15(1):44807

Advanced glycation end products induce inflammaging in periodontal ligament fibroblasts through RAGE/AKT/mTOR/glycolysis pathway.

Xiong L, Shu J, Gao H, Qin Y, Zhang Y, Chang X, Dong Q, Chen H
Acta odontologica Scandinavica 2025 Aug 21;84:479-490

Dl-3-n-butylphthalide ameliorates diabetic foot ulcer by inhibiting apoptosis and promoting angiogenesis.

Wei WH, Bai YL, Zhu D, Zhang JY, Yin QC, Li Q, Shen CQ, Jin PS
World journal of diabetes 2025 Apr 15;16(4):101916

HMGB1 Modulates High Glucose-Induced Erroneous Differentiation of Tendon Stem/Progenitor Cells through RAGE/β-Catenin Pathway.

Lu P, Dai G, Shi L, Li Y, Zhang M, Wang H, Rui Y
Stem cells international 2024;2024:2335270

Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration.

Ng B, Huang KY, Pua CJ, Viswanathan S, Lim WW, Kuthubudeen FF, Liu YN, Hii AA, George BL, Widjaja AA, Petretto E, Cook SA
Nature communications 2024 Oct 2;15(1):8530

Astrocyte-derived CHI3L1 signaling impairs neurogenesis and cognition in the demyelinated hippocampus.

Song Y, Jiang W, Afridi SK, Wang T, Zhu F, Xu H, Nazir FH, Liu C, Wang Y, Long Y, Huang YA, Qiu W, Tang C
Cell reports 2024 May 28;43(5):114226

Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop.

Yang S, Xie J, Pan Z, Guan H, Tu Y, Ye Y, Huang S, Fu S, Li K, Huang Z, Li X, Shi Z, Li L, Zhang Y
Experimental & molecular medicine 2024 Mar;56(3):630-645

Fei-Yan-Qing-Hua decoction decreases hyperinflammation by inhibiting HMGB1/RAGE signaling and promotes bacterial phagocytosis in the treatment of sepsis.

Zhang H, Xu G, Wu X, Xu Y, Xu L, Zou Y, Yang X, Pan L, Lei B, Mu J, Huang Q, Ma Y, Duan N, Zhang W, Zheng Y
Journal of ethnopharmacology 2024 Mar 1;321:117553

Oxymatrine attenuates sepsis-induced inflammation and organ injury via inhibition of HMGB1/RAGE/NF-κB signaling pathway.

He J, Qin W, Jiang S, Lin Y, Lin Y, Yang R, Xu M, Liu Q
Drug development research 2024 Jun;85(4):e22219

Maternal obstructive sleep apnea aggravates metabolic dysfunction-associated fatty liver disease via HMGB1-TLR4 signaling-mediated endoplasmic reticulum stress in male offspring rats.

Wang R, Feng W, Wang Y, Jiang Y, Lin Y, Chen X
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166889

S100A8/A9 promotes endometrial fibrosis via regulating RAGE/JAK2/STAT3 signaling pathway.

Xin X, Liu H, Zhang S, Li P, Zhao X, Zhang X, Li S, Wu S, Zhao F, Tan J
Communications biology 2024 Jan 22;7(1):116

FPS-ZM1 attenuates the deposition of lipid in the liver of diabetic mice by sterol regulatory element binding protein-1c.

Zhang M, Zhao W, Zhang Z, He M, Zhang Y, Song B, Liu J, Zhang H
BMC endocrine disorders 2024 Aug 29;24(1):164

Protective effect of heat-processed Gynostemma pentaphyllum on high fat diet-induced glucose metabolic disorders mice.

Xie JB, Xie P, Guo M, Li FF, Xiao MY, Qi YS, Pei WJ, Luo HT, Gu YL, Piao XL
Frontiers in pharmacology 2023;14:1215150

Macrophage RAGE deficiency prevents myocardial fibrosis by repressing autophagy-mediated macrophage alternative activation.

He J, Wei L, Tan S, Liang B, Liu J, Lu L, Wang T, Wang J, Huang Y, Chen Z, Li H, Zhang L, Zhou Z, Cao Y, Ye X, Yang Z, Xian S, Wang L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Nov;37(11):e23259

Advanced Glycation End Products and Bone Metabolism in Patients with Chronic Kidney Disease.

Quadros KRS, Roza NAV, França RA, Esteves ABA, Barreto J, Dominguez WV, Furukawa LNS, Caramori JT, Sposito AC, de Oliveira RB
JBMR plus 2023 Mar;7(3):e10727

RAGE signaling pathway is involved in CUS-induced depression-like behaviors by regulating the expression of NR2A and NR2B in rat hippocampus DG.

Zhang L, Luo L, Xue L, Ran D, Yang F, Tang Q, Jiang W
Experimental neurology 2023 Mar;361:114299

Pterostilbene could alleviate diabetic cognitive impairment by suppressing TLR4/NF-кB pathway through microbiota-gut-brain axis.

Zhang ZT, Deng SM, Chen C, He QH, Peng XW, Liang QF, Zhuang GD, Wang SM, Tang D
Phytotherapy research : PTR 2023 Aug;37(8):3522-3542

AGEs promote atherosclerosis by increasing LDL transcytosis across endothelial cells via RAGE/NF-κB/Caveolin-1 pathway.

Shu M, Cheng W, Jia X, Bai X, Zhao Y, Lu Y, Zhu L, Zhu Y, Wang L, Shu Y, Song Y, Jin S
Molecular medicine (Cambridge, Mass.) 2023 Aug 21;29(1):113

Glycyrrhizin regulates rat TMJOA progression by inhibiting the HMGB1-RAGE/TLR4-NF-κB/AKT pathway.

Hu Z, Xiao M, Cai H, Li W, Fang W, Long X
Journal of cellular and molecular medicine 2022 Feb;26(3):925-936

NAG-1/GDF15 inhibits diabetic nephropathy via inhibiting AGE/RAGE-mediated inflammation signaling pathways in C57BL/6 mice and HK-2 cells.

Chen J, Peng H, Chen C, Wang Y, Sang T, Cai Z, Zhao Q, Chen S, Lin X, Eling T, Wang X
Life sciences 2022 Dec 15;311(Pt A):121142

Harm of circadian misalignment to the hearts of the adolescent wistar rats.

Wang Y, Hou Y, Song S, Zuo Y, Yu Y, Chi Y, Zhang T
Journal of translational medicine 2022 Aug 6;20(1):352

l-Theanine Ameliorates d-Galactose-Induced Brain Damage in Rats via Inhibiting AGE Formation and Regulating Sirtuin1 and BDNF Signaling Pathways.

Zeng L, Lin L, Chen L, Xiao W, Gong Z
Oxidative medicine and cellular longevity 2021;2021:8850112

Roles of RAGE/ROCK1 Pathway in HMGB1-Induced Early Changes in Barrier Permeability of Human Pulmonary Microvascular Endothelial Cell.

Zhao MJ, Jiang HR, Sun JW, Wang ZA, Hu B, Zhu CR, Yin XH, Chen MM, Ma XC, Zhao WD, Luan ZG
Frontiers in immunology 2021;12:697071

Proof-of-concept study investigating the role of S100P-RAGE in nasopharyngeal carcinoma.

Wang C, Wang X, Han A, Wang Y, Jiang H
Experimental and therapeutic medicine 2021 May;21(5):470

HMGB1 signaling-regulated endoplasmic reticulum stress mediates intestinal ischemia/reperfusion-induced acute renal damage.

Lai HJ, Zhan YQ, Qiu YX, Ling YH, Zhang XY, Chang ZN, Zhang YN, Liu ZM, Wen SH
Surgery 2021 Jul;170(1):239-248

Celastrol exerts a neuroprotective effect by directly binding to HMGB1 protein in cerebral ischemia-reperfusion.

Liu DD, Luo P, Gu L, Zhang Q, Gao P, Zhu Y, Chen X, Guo Q, Zhang J, Ma N, Wang J
Journal of neuroinflammation 2021 Aug 9;18(1):174

An integrated network pharmacology and transcriptomic method to explore the mechanism of the total Rhizoma Coptidis alkaloids in improving diabetic nephropathy.

Xiao Y, Liu Y, Lai Z, Huang J, Li C, Zhang Y, Gong X, Deng J, Ye X, Li X
Journal of ethnopharmacology 2021 Apr 24;270:113806

Neuroprotective Effects of Celastrol on Transient Global Cerebral Ischemia Rats via Regulating HMGB1/NF-κB Signaling Pathway.

Zhang B, Zhong Q, Chen X, Wu X, Sha R, Song G, Zhang C, Chen X
Frontiers in neuroscience 2020;14:847

Aucubin Attenuates Liver Ischemia-Reperfusion Injury by Inhibiting the HMGB1/TLR-4/NF-κB Signaling Pathway, Oxidative Stress, and Apoptosis.

Zhang S, Feng Z, Gao W, Duan Y, Fan G, Geng X, Wu B, Li K, Liu K, Peng C
Frontiers in pharmacology 2020;11:544124

RAGE Signaling pathway in hippocampus dentate gyrus involved in GLT-1 decrease induced by chronic unpredictable stress in rats.

Yang F, Wang H, Chen H, Ran D, Tang Q, Weng P, Sun Y, Jiang W
Brain research bulletin 2020 Oct;163:49-56

Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages/microglia polarization and affords neuroprotection after spinal cord injury.

Fan H, Tang HB, Chen Z, Wang HQ, Zhang L, Jiang Y, Li T, Yang CF, Wang XY, Li X, Wu SX, Zhang GL
Journal of neuroinflammation 2020 Oct 9;17(1):295

AGEs-RAGE axis causes endothelial-to-mesenchymal transition in early calcific aortic valve disease via TGF-β1 and BMPR2 signaling.

Deng G, Zhang L, Wang C, Wang S, Xu J, Dong J, Kang Q, Zhai X, Zhao Y, Shan Z
Experimental gerontology 2020 Nov;141:111088

HMGB1 mediates homocysteine-induced endothelial cells pyroptosis via cathepsin V-dependent pathway.

Leng Y, Chen R, Chen R, He S, Shi X, Zhou X, Zhang Z, Chen AF
Biochemical and biophysical research communications 2020 Nov 19;532(4):640-646

HMGB1-associated necroptosis and Kupffer cells M1 polarization underlies remote liver injury induced by intestinal ischemia/reperfusion in rats.

Wen S, Li X, Ling Y, Chen S, Deng Q, Yang L, Li Y, Shen J, Qiu Y, Zhan Y, Lai H, Zhang X, Ke Z, Huang W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Mar;34(3):4384-4402

IL-12p40 and sRAGE in serum correlate with chemically induced cleft palate in mice.

Wang XH, Peng Y, Meng LY
Human & experimental toxicology 2020 Dec;39(12):1661-1670

HMGB1 Mediates Paraquat-Induced Neuroinflammatory Responses via Activating RAGE Signaling Pathway.

Huang M, Guo M, Wang K, Wu K, Li Y, Tian T, Wang Y, Yan W, Zhou Z, Yang H
Neurotoxicity research 2020 Apr;37(4):913-925

Aqueous extracts of se-enriched Auricularia auricular attenuates D-galactose-induced cognitive deficits, oxidative stress and neuroinflammation via suppressing RAGE/MAPK/NF-κB pathway.

Wang J, Zhang T, Liu X, Fan H, Wei C
Neuroscience letters 2019 Jun 21;704:106-111

Sialic Acid-Functionalized PEG-PLGA Microspheres Loading Mitochondrial-Targeting-Modified Curcumin for Acute Lung Injury Therapy.

Jin F, Liu D, Yu H, Qi J, You Y, Xu X, Kang X, Wang X, Lu K, Ying X, You J, Du Y, Ji J
Molecular pharmaceutics 2019 Jan 7;16(1):71-85

Pro-inflammatory role of high-mobility group box-1 on brain mast cells via the RAGE/NF-κB pathway.

Qian QQ, Zhang X, Wang YW, Xu JW, Dong HQ, Li NN, Qian YN, Gui B
Journal of neurochemistry 2019 Dec;151(5):595-607

High glucose-induced complement component 3 up-regulation via RAGE-p38MAPK-NF-κB signalling in astrocytes: In vivo and in vitro studies.

Zhao Y, Luo C, Chen J, Sun Y, Pu D, Lv A, Zhu S, Wu J, Wang M, Zhou J, Liao Z, Zhao K, Xiao Q
Journal of cellular and molecular medicine 2018 Dec;22(12):6087-6098

Heparanase-driven inflammation from the AGEs-stimulated macrophages changes the functions of glomerular endothelial cells.

Xu G, Qin Q, Yang M, Qiao Z, Gu Y, Niu J
Diabetes research and clinical practice 2017 Feb;124:30-40

Lower concentrations of receptor for advanced glycation end products and epiregulin in amniotic fluid correlate to chemically induced cleft palate in mice.

Wang X, Zhu J, Fang Y, Bian Z, Meng L
Environmental toxicology and pharmacology 2017 Apr;51:45-50

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse lung tissue were subjected to SDS PAGE followed by western blot with 16346-1-AP( AGER Antibody) at dilution of 1:600
Other comments: WB
Appendix: 16346-1-AP.pdf

: Show more

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemistry of paraffin-embedded human renal cell carcinoma tissue slide using 16346-1-AP( AGER Antibody) at dilution of 1:50 (under 10x lens)
Other comments: IHC
Appendix: 16346-1-AP.pdf

: Show more