GTX23611

Sukjamnong S, Chan YL, Zakarya R, Saad S, Sharma P, Santiyanont R, Chen H, Oliver BG
American journal of physiology. Lung cellular and molecular physiology 2017 Aug 1;313(2):L416-L423

Type I collagen aging impairs discoidin domain receptor 2-mediated tumor cell growth suppression.

Saby C, Buache E, Brassart-Pasco S, El Btaouri H, Courageot MP, Van Gulick L, Garnotel R, Jeannesson P, Morjani H
Oncotarget 2016 May 3;7(18):24908-27

High mobility group box 1-induced epithelial mesenchymal transition in human airway epithelial cells.

Chen YC, Statt S, Wu R, Chang HT, Liao JW, Wang CN, Shyu WC, Lee CC
Scientific reports 2016 Jan 7;6:18815

Receptor for Advanced Glycation End Products and its Inflammatory Ligands are Upregulated in Amyotrophic Lateral Sclerosis.

Juranek JK, Daffu GK, Wojtkiewicz J, Lacomis D, Kofler J, Schmidt AM
Frontiers in cellular neuroscience 2015;9:485

RAGE Suppresses ABCG1-Mediated Macrophage Cholesterol Efflux in Diabetes.

Daffu G, Shen X, Senatus L, Thiagarajan D, Abedini A, Hurtado Del Pozo C, Rosario R, Song F, Friedman RA, Ramasamy R, Schmidt AM
Diabetes 2015 Dec;64(12):4046-60

Inhibition of high-mobility group box 1 in lung reduced airway inflammation and remodeling in a mouse model of chronic asthma.

Lee CC, Lai YT, Chang HT, Liao JW, Shyu WC, Li CY, Wang CN
Biochemical pharmacology 2013 Oct 1;86(7):940-9

Signal transduction in receptor for advanced glycation end products (RAGE): solution structure of C-terminal rage (ctRAGE) and its binding to mDia1.

Rai V, Maldonado AY, Burz DS, Reverdatto S, Yan SF, Schmidt AM, Shekhtman A
The Journal of biological chemistry 2012 Feb 10;287(7):5133-44

Lysophosphatidic acid targets vascular and oncogenic pathways via RAGE signaling.

Rai V, Touré F, Chitayat S, Pei R, Song F, Li Q, Zhang J, Rosario R, Ramasamy R, Chazin WJ, Schmidt AM
The Journal of experimental medicine 2012 Dec 17;209(13):2339-50

Receptor for advanced glycation endproducts mediates pro-atherogenic responses to periodontal infection in vascular endothelial cells.

Pollreisz A, Hudson BI, Chang JS, Qu W, Cheng B, Papapanou PN, Schmidt AM, Lalla E
Atherosclerosis 2010 Oct;212(2):451-6

RAGE modulates hypoxia/reoxygenation injury in adult murine cardiomyocytes via JNK and GSK-3beta signaling pathways.

Shang L, Ananthakrishnan R, Li Q, Quadri N, Abdillahi M, Zhu Z, Qu W, Rosario R, Touré F, Yan SF, Schmidt AM, Ramasamy R
PloS one 2010 Apr 9;5(4):e10092

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Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: Western Blot detection of RAGE from mouse lung extract using GTX23611.
Validation comment: WB

Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: immunohistochemical staining of RAGE from transgenic mouse retinas using GTX23611.
Validation comment: WB

Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: Whole cell extract (30 ?g) was separated by 10% SDS-PAGE, and the membrane was blotted with RAGE antibody (GTX23611) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: Rat tissue extract (50 ?g) was separated by 10% SDS-PAGE, and the membrane was blotted with RAGE antibody (GTX23611) diluted at 1:5000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: Mouse tissue extract (50 ?g) was separated by 12% SDS-PAGE, and the membrane was blotted with RAGE antibody (GTX23611) diluted at 1:5000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: IHC-P analysis of normal mouse heart tissue with (ledt) or without (right) RAGE antibody at a dilution of 1:20. Heat induced antigen retrieval was performed using 10mM sodium citrate (pH6.0) buffer, microwaved for 8-15 minutes.

Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: IHC-P analysis of normal mouse kidney tissue with (ledt) or without (right) RAGE antibody at a dilution of 1:20. Heat induced antigen retrieval was performed using 10mM sodium citrate (pH6.0) buffer, microwaved for 8-15 minutes.

Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: IHC-P analysis of normal mouse lymph node tissue with (ledt) or without (right) RAGE antibody at a dilution of 1:20. Heat induced antigen retrieval was performed using 10mM sodium citrate (pH6.0) buffer, microwaved for 8-15 minutes.

Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: RAGE antibody detects RAGE protein in rat lung by immunohistochemical analysis. Sample: Paraffin-embedded rat lung. RAGE antibody (GTX23611) diluted at 1:400.