Antibody data
- Antibody Data
- Antigen structure
- References [13]
- Comments [0]
- Validations
- Western blot [5]
- Immunohistochemistry [4]
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Validation data
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- Product number
- GTX23611 - Provider product page
- Provider
- GeneTex
- Proper citation
- GeneTex Cat#GTX23611, RRID:AB_385109
- Product name
- RAGE antibody
- Antibody type
- Polyclonal
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
Submitted references Pro-inflammatory AGE-RAGE signaling is activated during arousal from hibernation in ground squirrel adipose.
Novel Interplay Between Smad1 and Smad3 Phosphorylation via AGE Regulates the Progression of Diabetic Nephropathy.
The Effects of Low-Power Laser Irradiation on Inflammation and Apoptosis in Submandibular Glands of Diabetes-Induced Rats.
Effect of long-term maternal smoking on the offspring's lung health.
Type I collagen aging impairs discoidin domain receptor 2-mediated tumor cell growth suppression.
High mobility group box 1-induced epithelial mesenchymal transition in human airway epithelial cells.
Receptor for Advanced Glycation End Products and its Inflammatory Ligands are Upregulated in Amyotrophic Lateral Sclerosis.
RAGE Suppresses ABCG1-Mediated Macrophage Cholesterol Efflux in Diabetes.
Inhibition of high-mobility group box 1 in lung reduced airway inflammation and remodeling in a mouse model of chronic asthma.
Signal transduction in receptor for advanced glycation end products (RAGE): solution structure of C-terminal rage (ctRAGE) and its binding to mDia1.
Lysophosphatidic acid targets vascular and oncogenic pathways via RAGE signaling.
Receptor for advanced glycation endproducts mediates pro-atherogenic responses to periodontal infection in vascular endothelial cells.
RAGE modulates hypoxia/reoxygenation injury in adult murine cardiomyocytes via JNK and GSK-3beta signaling pathways.
Logan SM, Storey KB
PeerJ 2018;6:e4911
PeerJ 2018;6:e4911
Novel Interplay Between Smad1 and Smad3 Phosphorylation via AGE Regulates the Progression of Diabetic Nephropathy.
Ono H, Abe H, Sakurai A, Ochi A, Tominaga T, Tamaki M, Kishi S, Murakami T, Nagai K, Kohashi M, Doi T
Scientific reports 2018 Jul 12;8(1):10548
Scientific reports 2018 Jul 12;8(1):10548
The Effects of Low-Power Laser Irradiation on Inflammation and Apoptosis in Submandibular Glands of Diabetes-Induced Rats.
Fukuoka CY, Simões A, Uchiyama T, Arana-Chavez VE, Abiko Y, Kuboyama N, Bhawal UK
PloS one 2017;12(1):e0169443
PloS one 2017;12(1):e0169443
Effect of long-term maternal smoking on the offspring's lung health.
Sukjamnong S, Chan YL, Zakarya R, Saad S, Sharma P, Santiyanont R, Chen H, Oliver BG
American journal of physiology. Lung cellular and molecular physiology 2017 Aug 1;313(2):L416-L423
American journal of physiology. Lung cellular and molecular physiology 2017 Aug 1;313(2):L416-L423
Type I collagen aging impairs discoidin domain receptor 2-mediated tumor cell growth suppression.
Saby C, Buache E, Brassart-Pasco S, El Btaouri H, Courageot MP, Van Gulick L, Garnotel R, Jeannesson P, Morjani H
Oncotarget 2016 May 3;7(18):24908-27
Oncotarget 2016 May 3;7(18):24908-27
High mobility group box 1-induced epithelial mesenchymal transition in human airway epithelial cells.
Chen YC, Statt S, Wu R, Chang HT, Liao JW, Wang CN, Shyu WC, Lee CC
Scientific reports 2016 Jan 7;6:18815
Scientific reports 2016 Jan 7;6:18815
Receptor for Advanced Glycation End Products and its Inflammatory Ligands are Upregulated in Amyotrophic Lateral Sclerosis.
Juranek JK, Daffu GK, Wojtkiewicz J, Lacomis D, Kofler J, Schmidt AM
Frontiers in cellular neuroscience 2015;9:485
Frontiers in cellular neuroscience 2015;9:485
RAGE Suppresses ABCG1-Mediated Macrophage Cholesterol Efflux in Diabetes.
Daffu G, Shen X, Senatus L, Thiagarajan D, Abedini A, Hurtado Del Pozo C, Rosario R, Song F, Friedman RA, Ramasamy R, Schmidt AM
Diabetes 2015 Dec;64(12):4046-60
Diabetes 2015 Dec;64(12):4046-60
Inhibition of high-mobility group box 1 in lung reduced airway inflammation and remodeling in a mouse model of chronic asthma.
Lee CC, Lai YT, Chang HT, Liao JW, Shyu WC, Li CY, Wang CN
Biochemical pharmacology 2013 Oct 1;86(7):940-9
Biochemical pharmacology 2013 Oct 1;86(7):940-9
Signal transduction in receptor for advanced glycation end products (RAGE): solution structure of C-terminal rage (ctRAGE) and its binding to mDia1.
Rai V, Maldonado AY, Burz DS, Reverdatto S, Yan SF, Schmidt AM, Shekhtman A
The Journal of biological chemistry 2012 Feb 10;287(7):5133-44
The Journal of biological chemistry 2012 Feb 10;287(7):5133-44
Lysophosphatidic acid targets vascular and oncogenic pathways via RAGE signaling.
Rai V, Touré F, Chitayat S, Pei R, Song F, Li Q, Zhang J, Rosario R, Ramasamy R, Chazin WJ, Schmidt AM
The Journal of experimental medicine 2012 Dec 17;209(13):2339-50
The Journal of experimental medicine 2012 Dec 17;209(13):2339-50
Receptor for advanced glycation endproducts mediates pro-atherogenic responses to periodontal infection in vascular endothelial cells.
Pollreisz A, Hudson BI, Chang JS, Qu W, Cheng B, Papapanou PN, Schmidt AM, Lalla E
Atherosclerosis 2010 Oct;212(2):451-6
Atherosclerosis 2010 Oct;212(2):451-6
RAGE modulates hypoxia/reoxygenation injury in adult murine cardiomyocytes via JNK and GSK-3beta signaling pathways.
Shang L, Ananthakrishnan R, Li Q, Quadri N, Abdillahi M, Zhu Z, Qu W, Rosario R, Touré F, Yan SF, Schmidt AM, Ramasamy R
PloS one 2010 Apr 9;5(4):e10092
PloS one 2010 Apr 9;5(4):e10092
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Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Western Blot detection of RAGE from mouse lung extract using GTX23611.
- Validation comment
- WB
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- immunohistochemical staining of RAGE from transgenic mouse retinas using GTX23611.
- Validation comment
- WB
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Whole cell extract (30 ?g) was separated by 10% SDS-PAGE, and the membrane was blotted with RAGE antibody (GTX23611) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Rat tissue extract (50 ?g) was separated by 10% SDS-PAGE, and the membrane was blotted with RAGE antibody (GTX23611) diluted at 1:5000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Mouse tissue extract (50 ?g) was separated by 12% SDS-PAGE, and the membrane was blotted with RAGE antibody (GTX23611) diluted at 1:5000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- IHC-P analysis of normal mouse heart tissue with (ledt) or without (right) RAGE antibody at a dilution of 1:20. Heat induced antigen retrieval was performed using 10mM sodium citrate (pH6.0) buffer, microwaved for 8-15 minutes.
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- IHC-P analysis of normal mouse kidney tissue with (ledt) or without (right) RAGE antibody at a dilution of 1:20. Heat induced antigen retrieval was performed using 10mM sodium citrate (pH6.0) buffer, microwaved for 8-15 minutes.
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- IHC-P analysis of normal mouse lymph node tissue with (ledt) or without (right) RAGE antibody at a dilution of 1:20. Heat induced antigen retrieval was performed using 10mM sodium citrate (pH6.0) buffer, microwaved for 8-15 minutes.
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- RAGE antibody detects RAGE protein in rat lung by immunohistochemical analysis. Sample: Paraffin-embedded rat lung. RAGE antibody (GTX23611) diluted at 1:400.