14-9937-82

antibody from Invitrogen Antibodies
Targeting: NDUFA13 B16.6, CDA016, CGI-39, GRIM-19, GRIM19
Provider product page for 14-9937-82
Western blot
Immunohistochemistry
Other assay

Antibody data

Product number
14-9937-82 - Provider product page
Provider
Invitrogen Antibodies
Product name
Grim-19 Monoclonal Antibody (1A8), eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: This 1A8 monoclonal antibody reacts with human, mouse, and rat Grim-19. This 16 kDa protein is expressed in many human tissues, especially in the heart and skeletal muscle. Lower expression levels of Grim-19 can be observed in the liver, kidney, and brain. Originally described as a nuclear protein, reports indicate that Grim-19 is primarily localized to mitochondria as an essential component of complex I of the electron transport chain. Grim-19 expression can be induced by interferon-beta and all-trans-retinoic acid in tumor cell lines, leading to cell death. Finally, Grim-19 has been shown to bind the transactivation domain of STAT3 and inhibit its transcriptional activity. The molecular mechanisms of how Grim-19 regulates STAT3 within the cell remains under active investigation. Applications Reported: This 1A8 antibody has been reported for use in immunoblotting, immunohistochemical staining of formalin-fixed paraffin embedded tissue sections, and immunocytochemistry. Applications Tested: This 1A8 antibody has been tested by immunoblotting of HeLa cell lysate. This can be used at less than or equal to 5 µg/mL. It is recommended that the antibody be titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 µm post-manufacturing filtered.
Reactivity
Human, Mouse, Rat
Host
Mouse
Isotype
IgG
Antibody clone number
1A8
Vial size
100 µg
Concentration
0.5 mg/mL
Storage
4°C
NDUFA13 protein structure - 14-9937-82 shown in red.