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antibody from Invitrogen Antibodies
Targeting: NDUFA13
B16.6, CDA016, CGI-39, GRIM-19, GRIM19
Western blotAntibody data
- Antibody Data
- Antigen structure
- References [12]
- Comments [0]
- Validations
- Western blot [1]
- Other assay [1]
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- Product number
- 14-9937-82 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Grim-19 Monoclonal Antibody (1A8), eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: This 1A8 monoclonal antibody reacts with human, mouse, and rat Grim-19. This 16 kDa protein is expressed in many human tissues, especially in the heart and skeletal muscle. Lower expression levels of Grim-19 can be observed in the liver, kidney, and brain. Originally described as a nuclear protein, reports indicate that Grim-19 is primarily localized to mitochondria as an essential component of complex I of the electron transport chain. Grim-19 expression can be induced by interferon-beta and all-trans-retinoic acid in tumor cell lines, leading to cell death. Finally, Grim-19 has been shown to bind the transactivation domain of STAT3 and inhibit its transcriptional activity. The molecular mechanisms of how Grim-19 regulates STAT3 within the cell remains under active investigation.
- Antibody clone number
- 1A8
- Concentration
- 0.5 mg/mL
Submitted references Discrete viral E2 lysine residues and scavenger receptor MARCO are required for clearance of circulating alphaviruses.
Early IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology.
Immune signatures of protective spleen memory CD8 T cells.
Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice.
Pneumolysin expression by streptococcus pneumoniae protects colonized mice from influenza virus-induced disease.
Anatomically restricted synergistic antiviral activities of innate and adaptive immune cells in the skin.
Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo.
A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils.
GRIM-19, a cell death regulatory protein, is essential for assembly and function of mitochondrial complex I.
The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3.
Characterization of monoclonal antibodies against GRIM-19, a novel IFN-beta and retinoic acid-activated regulator of cell death.
Identification of GRIM-19, a novel cell death-regulatory gene induced by the interferon-beta and retinoic acid combination, using a genetic approach.
Carpentier KS, Davenport BJ, Haist KC, McCarthy MK, May NA, Robison A, Ruckert C, Ebel GD, Morrison TE
eLife 2019 Oct 9;8
eLife 2019 Oct 9;8
Early IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology.
Pyle CJ, Uwadiae FI, Swieboda DP, Harker JA
PLoS pathogens 2017 Sep;13(9):e1006640
PLoS pathogens 2017 Sep;13(9):e1006640
Immune signatures of protective spleen memory CD8 T cells.
Brinza L, Djebali S, Tomkowiak M, Mafille J, Loiseau C, Jouve PE, de Bernard S, Buffat L, Lina B, Ottmann M, Rosa-Calatrava M, Schicklin S, Bonnefoy N, Lauvau G, Grau M, Wencker M, Arpin C, Walzer T, Leverrier Y, Marvel J
Scientific reports 2016 Nov 24;6:37651
Scientific reports 2016 Nov 24;6:37651
Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice.
Stark K, Philippi V, Stockhausen S, Busse J, Antonelli A, Miller M, Schubert I, Hoseinpour P, Chandraratne S, von Brühl ML, Gaertner F, Lorenz M, Agresti A, Coletti R, Antoine DJ, Heermann R, Jung K, Reese S, Laitinen I, Schwaiger M, Walch A, Sperandio M, Nawroth PP, Reinhardt C, Jäckel S, Bianchi ME, Massberg S
Blood 2016 Nov 17;128(20):2435-2449
Blood 2016 Nov 17;128(20):2435-2449
Pneumolysin expression by streptococcus pneumoniae protects colonized mice from influenza virus-induced disease.
Wolf AI, Strauman MC, Mozdzanowska K, Williams KL, Osborne LC, Shen H, Liu Q, Garlick D, Artis D, Hensley SE, Caton AJ, Weiser JN, Erikson J
Virology 2014 Aug;462-463:254-65
Virology 2014 Aug;462-463:254-65
Anatomically restricted synergistic antiviral activities of innate and adaptive immune cells in the skin.
Hickman HD, Reynoso GV, Ngudiankama BF, Rubin EJ, Magadán JG, Cush SS, Gibbs J, Molon B, Bronte V, Bennink JR, Yewdell JW
Cell host & microbe 2013 Feb 13;13(2):155-68
Cell host & microbe 2013 Feb 13;13(2):155-68
Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo.
von Brühl ML, Stark K, Steinhart A, Chandraratne S, Konrad I, Lorenz M, Khandoga A, Tirniceriu A, Coletti R, Köllnberger M, Byrne RA, Laitinen I, Walch A, Brill A, Pfeiler S, Manukyan D, Braun S, Lange P, Riegger J, Ware J, Eckart A, Haidari S, Rudelius M, Schulz C, Echtler K, Brinkmann V, Schwaiger M, Preissner KT, Wagner DD, Mackman N, Engelmann B, Massberg S
The Journal of experimental medicine 2012 Apr 9;209(4):819-35
The Journal of experimental medicine 2012 Apr 9;209(4):819-35
A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils.
Massena S, Christoffersson G, Hjertström E, Zcharia E, Vlodavsky I, Ausmees N, Rolny C, Li JP, Phillipson M
Blood 2010 Sep 16;116(11):1924-31
Blood 2010 Sep 16;116(11):1924-31
GRIM-19, a cell death regulatory protein, is essential for assembly and function of mitochondrial complex I.
Huang G, Lu H, Hao A, Ng DC, Ponniah S, Guo K, Lufei C, Zeng Q, Cao X
Molecular and cellular biology 2004 Oct;24(19):8447-56
Molecular and cellular biology 2004 Oct;24(19):8447-56
The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3.
Zhang J, Yang J, Roy SK, Tininini S, Hu J, Bromberg JF, Poli V, Stark GR, Kalvakolanu DV
Proceedings of the National Academy of Sciences of the United States of America 2003 Aug 5;100(16):9342-7
Proceedings of the National Academy of Sciences of the United States of America 2003 Aug 5;100(16):9342-7
Characterization of monoclonal antibodies against GRIM-19, a novel IFN-beta and retinoic acid-activated regulator of cell death.
Hu J, Angell JE, Zhang J, Ma X, Seo T, Raha A, Hayashi J, Choe J, Kalvakolanu DV
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002 Oct;22(10):1017-26
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002 Oct;22(10):1017-26
Identification of GRIM-19, a novel cell death-regulatory gene induced by the interferon-beta and retinoic acid combination, using a genetic approach.
Angell JE, Lindner DJ, Shapiro PS, Hofmann ER, Kalvakolanu DV
The Journal of biological chemistry 2000 Oct 27;275(43):33416-26
The Journal of biological chemistry 2000 Oct 27;275(43):33416-26
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunoblotting of reduced HeLa cell lysate with 5 µg/mL of Anti-Grim-19 Purified antibody. Bands were visualized using Anti-Mouse IgG HRP.
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
