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Blocking/NeutralizingAntibody data
- Antibody Data
- Antigen structure
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- Validations
- Blocking/Neutralizing [1]
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- Product number
- MAB8531 - Provider product page
- Provider
- R&D Systems
- Product name
- Mouse GDF-5/BMP-14 Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects mouse GDF-5/BMP-14 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant mouse (rm) GDF-1, rmPro-GDF-1, rmGDF-3, rmPro-GDF-3, rmGDF-6, rmGDF-7, rmGDF-8, rmGDF-9, rmPro-GDF-9, rmGDF-15, or recombinant human GDF-11 is observed.
- Reactivity
- Mouse
- Host
- Rat
- Conjugate
- Unconjugated
- Antigen sequence
P43027- Isotype
- IgG
- Antibody clone number
- 143004
- Vial size
- 500 ug
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
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Supportive validation
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- R&D Systems (provider)
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- Experimental details
- Alkaline Phosphatase Production Induced by GDF-5 and Neutralization by Mouse GDF-5 Antibody. Recombinant Mouse GDF-5 (Catalog # 853-G5) induces alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line in a dose-dependent manner (orange line). Alkaline phosphatase production elicited by Recombinant Mouse GDF-5 (3 µg/mL) is neutralized (green line) by increasing concentrations of Rat Anti-Mouse GDF-5 Monoclonal Antibody (Catalog # MAB8531). The ND50 is typically 2-10 µg/mL.
