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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [15]
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- Validations
- Immunohistochemistry [2]
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- Product number
- 17221-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17221-1-AP, RRID:AB_10639510
- Product name
- HLA-DRA antibody
- Antibody type
- Polyclonal
- Description
- HLA-DRA antibody (Cat. #17221-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat and has been validated for the following applications: FC, IHC, IP, WB,ELISA.
- Reactivity
- Human, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Dual regulation of CXCR6(+)CD8(+) T cells modulates cytotoxic and exhaustion-associated programs during prostate cancer progression.
Immune status in the mouse oviduct and uterine lumen across early embryogenesis to embryo implantation†.
Single-cell and spatial transcriptomic analysis reveal cellular heterogeneity and cancer cell-intrinsic major histocompatibility complex II expression in urothelial carcinoma.
Neoadjuvant PD-1 blockade induces the autophagy of immune cells: a new target for synergistic therapy of recurrent glioblastoma.
MACS and acellular autologous non-ovarian tissue scaffolds: a promising strategy for safe and efficient follicle transplantation in hematologic cancer.
Improved Immunotherapy Outcomes via Cuproptosis Upregulation of HLA-DRA Expression: Promoting the Aggregation of CD4(+) and CD8(+)T Lymphocytes in Clear Cell Renal Cell Carcinoma.
Crosstalk between cancer-associated fibroblasts and non-neuroendocrine tumor cells in small cell lung cancer involves in glycolysis and antigen-presenting features.
Combining single-cell spatial transcriptomics and molecular simulation to develop in vivo probes targeting the perineural invasion region of adenoid cystic carcinoma.
The molecular, immune features, and risk score construction of intraductal papillary mucinous neoplasm patients.
HLA class II molecule HLA-DRA identifies immuno-hot tumors and predicts the therapeutic response to anti-PD-1 immunotherapy in NSCLC.
An Immunological Perspective: What Happened to Pregnant Women After Recovering From COVID-19?
Donor BMSC-derived small extracellular vesicles relieve acute rejection post-renal allograft through transmitting Loc108349490 to dendritic cells.
Single-cell RNA sequencing highlights the role of inflammatory cancer-associated fibroblasts in bladder urothelial carcinoma.
Correction of immunosuppression in aged septic rats by human ghrelin and growth hormone through the vagus nerve-dependent inhibition of TGF-β production.
Functional Change of Effector Tumor-Infiltrating CCR5(+)CD38(+)HLA-DR(+)CD8(+) T Cells in Glioma Microenvironment.
Xingming Z, Wang J, Abudurexiti M, Du L, Zhang W, Ni X, Xu M, Zhang X, Zhang M, Yao Z, Bian X, Jin S, Wang W
Journal for immunotherapy of cancer 2026 Mar 11;14(3)
Journal for immunotherapy of cancer 2026 Mar 11;14(3)
Immune status in the mouse oviduct and uterine lumen across early embryogenesis to embryo implantation†.
An L, Ma M, Zhang L, Li C, Fan D, Mo Y, Duan L, Li W, Peng X
Biology of reproduction 2026 Apr 13;114(4):1277-1294
Biology of reproduction 2026 Apr 13;114(4):1277-1294
Single-cell and spatial transcriptomic analysis reveal cellular heterogeneity and cancer cell-intrinsic major histocompatibility complex II expression in urothelial carcinoma.
Xiong S, Fan J, Huang C, He S, Liang Y, Zhang Q, Guo B, Wu Y, Xia M, Zhao F, Ci W, Zhou L, Gong Y, Li X
International journal of biological sciences 2025;21(15):6649-6673
International journal of biological sciences 2025;21(15):6649-6673
Neoadjuvant PD-1 blockade induces the autophagy of immune cells: a new target for synergistic therapy of recurrent glioblastoma.
Xuan Z, Wang K, Zhu Q, Sun T, Jiang J, Wu Z, Zheng S, Zhao H
Biochemistry and biophysics reports 2025 Sep;43:102119
Biochemistry and biophysics reports 2025 Sep;43:102119
MACS and acellular autologous non-ovarian tissue scaffolds: a promising strategy for safe and efficient follicle transplantation in hematologic cancer.
Yin L, Zhao Y, Zhang P, Qi T, Han P, Cai L, Pan J, Yang Y, Shi J, Feng S, Zou Y, He K, Xie G, He W, Zhou X, Qian J
Journal of ovarian research 2025 Jun 10;18(1):126
Journal of ovarian research 2025 Jun 10;18(1):126
Improved Immunotherapy Outcomes via Cuproptosis Upregulation of HLA-DRA Expression: Promoting the Aggregation of CD4(+) and CD8(+)T Lymphocytes in Clear Cell Renal Cell Carcinoma.
Wang B, Liu Y, Xiong F, Wang C
Pharmaceuticals (Basel, Switzerland) 2024 May 24;17(6)
Pharmaceuticals (Basel, Switzerland) 2024 May 24;17(6)
Crosstalk between cancer-associated fibroblasts and non-neuroendocrine tumor cells in small cell lung cancer involves in glycolysis and antigen-presenting features.
Lu Y, Li H, Zhao P, Wang X, Shao W, Liu Y, Tian L, Zhong R, Liu H, Cheng Y
Molecular medicine (Cambridge, Mass.) 2024 Dec 25;30(1):274
Molecular medicine (Cambridge, Mass.) 2024 Dec 25;30(1):274
Combining single-cell spatial transcriptomics and molecular simulation to develop in vivo probes targeting the perineural invasion region of adenoid cystic carcinoma.
Yuan X, Dong Z, Zhang B, Li Q, Jiang W
Heliyon 2024 Aug 15;10(15):e34628
Heliyon 2024 Aug 15;10(15):e34628
The molecular, immune features, and risk score construction of intraductal papillary mucinous neoplasm patients.
Huang X, Feng Y, Ma D, Ding H, Dong G, Chen Y, Huang X, Zhang J, Xu X, Chen C
Frontiers in molecular biosciences 2022;9:887887
Frontiers in molecular biosciences 2022;9:887887
HLA class II molecule HLA-DRA identifies immuno-hot tumors and predicts the therapeutic response to anti-PD-1 immunotherapy in NSCLC.
Mei J, Jiang G, Chen Y, Xu Y, Wan Y, Chen R, Liu F, Mao W, Zheng M, Xu J
BMC cancer 2022 Jul 6;22(1):738
BMC cancer 2022 Jul 6;22(1):738
An Immunological Perspective: What Happened to Pregnant Women After Recovering From COVID-19?
Zhao S, Xie T, Shen L, Liu H, Wang L, Ma X, Wu J, Yuan S, Mor G, Liao A
Frontiers in immunology 2021;12:631044
Frontiers in immunology 2021;12:631044
Donor BMSC-derived small extracellular vesicles relieve acute rejection post-renal allograft through transmitting Loc108349490 to dendritic cells.
Wang ZG, Xu HE, Cheng FM, Zhang J, Feng YH, Liu DH, Shang WJ, Feng GW
Aging cell 2021 Oct;20(10):e13461
Aging cell 2021 Oct;20(10):e13461
Single-cell RNA sequencing highlights the role of inflammatory cancer-associated fibroblasts in bladder urothelial carcinoma.
Chen Z, Zhou L, Liu L, Hou Y, Xiong M, Yang Y, Hu J, Chen K
Nature communications 2020 Oct 8;11(1):5077
Nature communications 2020 Oct 8;11(1):5077
Correction of immunosuppression in aged septic rats by human ghrelin and growth hormone through the vagus nerve-dependent inhibition of TGF-β production.
Zhou M, Aziz M, Ochani M, Wang P
Molecular medicine (Cambridge, Mass.) 2020 Jul 16;26(1):71
Molecular medicine (Cambridge, Mass.) 2020 Jul 16;26(1):71
Functional Change of Effector Tumor-Infiltrating CCR5(+)CD38(+)HLA-DR(+)CD8(+) T Cells in Glioma Microenvironment.
Chen PY, Wu CY, Fang JH, Chen HC, Feng LY, Huang CY, Wei KC, Fang JY, Lin CY
Frontiers in immunology 2019;10:2395
Frontiers in immunology 2019;10:2395
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human tonsil using 17221-1-AP(HLA-DRA antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HLA-DRA antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human HLA-DRA. This antibody recognizes human, mouse, rat antigen. The HLA-DRA antibody has been validated for the following applications: ELISA, IHC analysis.
