BS6622

antibody from Bioworld Technology, Inc
Targeting: HLA-DRA HLA-DRA1
Provider product page for BS6622
Western blot
Immunohistochemistry

Antibody data

Product number
BS6622 - Provider product page
Provider
Bioworld Technology, Inc
Product name
HLA DRA polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human HLA-DRA.
Description
Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in mhc ii-a/b dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR, -DQ and -DP) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA-B belongs to the HLA class I heavy chain paralogs. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and -C can form heterodimers consisting of a membrane anchored heavy chain and a light chain (ÉÇ-2-Microglobulin). Polymorphisms yield hundreds of HLA-B and -C alleles.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
HLA-DRA protein structure - BS6622 shown in red.