Antibody data
- Antibody Data
- Antigen structure
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- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 10-4116 - Provider product page
- Provider
- ABEOMICS Inc.
- Product name
- Anti-HLADR Antibody
- Antibody type
- Monoclonal
- Description
- The HLA-DRA gene at 6p21.3 is one of the HLA class II alpha chain paralogues, and it plays a central role in the immune system by presenting peptides derived from extracellular proteins. Unlike the alpha chains of other Human MHC class II molecules, the alpha subunit is practically invariable. The promoter for the HLA-DRA is the most well studied, and it contains sites, from 5' to 3', for the trimeric RFX, CREB, the trimeric NF-Y, Oct-1, and YY1. RFX, CREB, and NF-Y contribute to the binding of the CIITA co-activator, which is either constitutively expressed in cells that constitutively express the MHC class II genes, or is induced by IFN-gamma activation of STAT1alpha. The beta-2 domain of the conserved HLA-DR alpha molecule encoded by the HLA-DRA1 locus interacts with the CD4 molecule in human lymphocytes. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages).
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
Human lymphoblastoid cell line was
used as an immunogen for this antib
ody.- Isotype
- IgG
- Antibody clone number
- L243
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
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Supportive validation
- Submitted by
- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Cell surface flow analysis of HLADR in human PBMC using 0.5 µg/10^6 cells of HLADR antibody (Clone: L243). Green represents isotype control; red represents anti-HLADR antibody. Goat anti-mouse PE conjugate was used as secondary antibody.
- Protocol
- Protocol