Antibody data
- Antibody Data
- Antigen structure
- References [14]
- Comments [0]
- Validations
- Immunohistochemistry [2]
- Flow cytometry [1]
- Other assay [1]
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Validation data
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- Product number
- V7421 - Provider product page
- Provider
- NSJ Bioreagents
- Product name
- HLA-DR Antibody (MHC II)
- Antibody type
- Monoclonal
- Description
- Protein G affinity chromatography
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antibody clone number
- TAL 1B5
- Vial size
- 20 µg, 100 µg (with BSA, sodium azide), 100 µg (without BSA, sodium azide), 7 ml (prediluted for IHC)
- Concentration
- 0.2 mg/ml, 1 mg/ml (BSA/azide free format), Prediluted (IHC only format)
- Storage
- Store the HLA-DR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Submitted references Quantification of HLA-DM-Dependent Major Histocompatibility Complex of Class II Immunopeptidomes by the Peptide Landscape Antigenic Epitope Alignment Utility.
Phenotype, Function, and Mobilization of 6-Sulfo LacNAc-Expressing Monocytes in Atopic Dermatitis.
Progression of Alzheimer's Disease-Related Pathology and Cell Counts in a Patient with Idiopathic Normal Pressure Hydrocephalus.
Characteristics of the tissue section that influence the staining outcome in immunohistochemistry.
Renal transplant recipients receiving loop diuretic therapy have increased urinary tract infection rate and altered medullary macrophage polarization marker expression.
Merkel cell carcinomas infiltrated with CD33+ myeloid cells and CD8+ T cells are associated with improved outcome.
Lesions Consistent with Tuberculous Spondylitis in Domestic and Wild Swine and Their Potential Use as a Model for Pott Disease in Humans.
Rechallenge With Nivolumab After Vemurafenib Treatment of Initially Nivolumab-Resistant Advanced Melanoma.
Intratumorally injected pro-inflammatory allogeneic dendritic cells as immune enhancers: a first-in-human study in unfavourable risk patients with metastatic renal cell carcinoma.
Clinical effect and immunological response in patients with advanced malignant glioma treated with WT1-pulsed dendritic cell-based immunotherapy: A report of two cases
Multinucleated giant cell reaction in lower lip squamous cell carcinoma: a clinical, morphological, and immunohistochemical study.
HLA-DR expression in tumor epithelium is an independent prognostic indicator in esophageal adenocarcinoma patients.
Enterovirus but not Parvovirus B19 is associated with idiopathic dilated cardiomyopathy and endomyocardial CD3, CD68, or HLA-DR expression.
Databases for technical aspects of immunohistochemistry.
Álvaro-Benito M, Morrison E, Abualrous ET, Kuropka B, Freund C
Frontiers in immunology 2018;9:872
Frontiers in immunology 2018;9:872
Phenotype, Function, and Mobilization of 6-Sulfo LacNAc-Expressing Monocytes in Atopic Dermatitis.
Baran W, Oehrl S, Ahmad F, Döbel T, Alt C, Buske-Kirschbaum A, Schmitz M, Schäkel K
Frontiers in immunology 2018;9:1352
Frontiers in immunology 2018;9:1352
Progression of Alzheimer's Disease-Related Pathology and Cell Counts in a Patient with Idiopathic Normal Pressure Hydrocephalus.
Libard S, Laurell K, Cesarini KG, Alafuzoff I
Journal of Alzheimer's disease : JAD 2018;61(4):1451-1462
Journal of Alzheimer's disease : JAD 2018;61(4):1451-1462
Characteristics of the tissue section that influence the staining outcome in immunohistochemistry.
Libard S, Cerjan D, Alafuzoff I
Histochemistry and cell biology 2018 Oct 24;
Histochemistry and cell biology 2018 Oct 24;
Renal transplant recipients receiving loop diuretic therapy have increased urinary tract infection rate and altered medullary macrophage polarization marker expression.
Casper J, Schmitz J, Bräsen JH, Khalifa A, Schmidt BMW, Einecke G, Haller H, von Vietinghoff S
Kidney international 2018 Nov;94(5):993-1001
Kidney international 2018 Nov;94(5):993-1001
Merkel cell carcinomas infiltrated with CD33+ myeloid cells and CD8+ T cells are associated with improved outcome.
Kervarrec T, Gaboriaud P, Berthon P, Zaragoza J, Schrama D, Houben R, Le Corre Y, Hainaut-Wierzbicka E, Aubin F, Bens G, Domenech J, Guyétant S, Touzé A, Samimi M
Journal of the American Academy of Dermatology 2018 May;78(5):973-982.e8
Journal of the American Academy of Dermatology 2018 May;78(5):973-982.e8
Lesions Consistent with Tuberculous Spondylitis in Domestic and Wild Swine and Their Potential Use as a Model for Pott Disease in Humans.
Amato B, Vitale M, Capucchio MT, Fiasconaro M, Gerace E, Puleio R, Di Marco Lo Presti V
Advances in experimental medicine and biology 2018 May 31;
Advances in experimental medicine and biology 2018 May 31;
Rechallenge With Nivolumab After Vemurafenib Treatment of Initially Nivolumab-Resistant Advanced Melanoma.
Kato J, Hida T, Kamiya T, Sato S, Takahashi H, Torigoe T, Uhara H
JAMA dermatology 2018 May 1;154(5):621-622
JAMA dermatology 2018 May 1;154(5):621-622
Intratumorally injected pro-inflammatory allogeneic dendritic cells as immune enhancers: a first-in-human study in unfavourable risk patients with metastatic renal cell carcinoma.
Laurell A, Lönnemark M, Brekkan E, Magnusson A, Tolf A, Wallgren AC, Andersson B, Adamson L, Kiessling R, Karlsson-Parra A
Journal for immunotherapy of cancer 2017;5:52
Journal for immunotherapy of cancer 2017;5:52
Clinical effect and immunological response in patients with advanced malignant glioma treated with WT1-pulsed dendritic cell-based immunotherapy: A report of two cases
Sakai K, Shimodaira S, Maejima S, Sano K, Higuchi Y, Koya T, Sugiyama H, Hongo K
Interdisciplinary Neurosurgery 2017 September;9
Interdisciplinary Neurosurgery 2017 September;9
Multinucleated giant cell reaction in lower lip squamous cell carcinoma: a clinical, morphological, and immunohistochemical study.
Santos HBP, Miguel MCDC, Pinto LP, Gordón-Núñez MA, Alves PM, Nonaka CFW
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2017 Oct;46(9):773-779
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2017 Oct;46(9):773-779
HLA-DR expression in tumor epithelium is an independent prognostic indicator in esophageal adenocarcinoma patients.
Dunne MR, Michielsen AJ, O'Sullivan KE, Cathcart MC, Feighery R, Doyle B, Watson JA, O'Farrell NJ, Ravi N, Kay E, Reynolds JV, Ryan EJ, O'Sullivan J
Cancer immunology, immunotherapy : CII 2017 Jul;66(7):841-850
Cancer immunology, immunotherapy : CII 2017 Jul;66(7):841-850
Enterovirus but not Parvovirus B19 is associated with idiopathic dilated cardiomyopathy and endomyocardial CD3, CD68, or HLA-DR expression.
N'Guyen Y, Lesaffre F, Metz D, Tassan S, Saade Y, Boulagnon C, Fornes P, Renois F, Andreoletti L
Journal of medical virology 2017 Jan;89(1):55-63
Journal of medical virology 2017 Jan;89(1):55-63
Databases for technical aspects of immunohistochemistry.
Furukawa S, Nagaike M, Ozaki K
Journal of toxicologic pathology 2017 Jan;30(1):79-107
Journal of toxicologic pathology 2017 Jan;30(1):79-107
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Supportive validation
- Submitted by
- NSJ Bioreagents (provider)
- Main image
- Experimental details
- IHC staining of FFPE human prostate cancer with HLA-DR antibody (clone TAL 1B5). HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min and allow to cool before testing.
- Submitted by
- NSJ Bioreagents (provider)
- Main image
- Experimental details
- IHC staining of FFPE human lung cancer with HLA-DR antibody (clone TAL 1B5). HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min and allow to cool before testing.
Supportive validation
- Submitted by
- NSJ Bioreagents (provider)
- Main image
- Experimental details
- Flow cytometry testing of human Raji cells with HLA-DR antibody (clone TAL 1B5); Red=isotype control, Blue= HLA-DR antibody.
Supportive validation
- Submitted by
- NSJ Bioreagents (provider)
- Main image
- Experimental details
- SDS-PAGE analysis of purified, BSA-free HLA-DR antibody (clone TAL 1B5) as confirmation of integrity and purity.