orb2640184

antibody from Biorbyt

Targeting: HLA-DRA HLA-DRA1

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Flow cytometry

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Validation data

Product number: orb2640184 - Provider product page
Provider: Biorbyt
Product name: HLA-DP + HLA-DQ + HLA-DR Antibody (MHC II)
Antibody type: Monoclonal
Description: This mAb reacts with a common epitope of human major histocompatibility (MHC) class II antigens, HLA-DP, -DQ and -DR. Human MHC class II antigens are transmembrane glycoproteins composed of an alpha chain (36kDa) and a beta chain (27kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, and thymic epithelial cells and are also present on activated T lymphocytes. Human MHC class II genes are located in the HLA-D region that encodes at least six alpha and ten beta chain genes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They, therefore, have a critical role in the initiation of the immune response. It has been shown that some auto-immune diseases are associated with certain class II alleles.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Antibody clone number: CR3/43
Vial size: 100 ug
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

HLA-DRA protein structure - orb2640184 shown in red.