Tissue expression
Cell line expression
Protein structure
DOCK2
Dedicator of cytokinesis 2KIAA0209
The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. Mutations in this gene result in immunodeficiency 40 (IMD40), a combined form of immunodeficiency that affects T cell number and function, also with variable defects in B cell and NK cell function. [provided by RefSeq, May 2018]
Top validated antibodies |
|||||
St John's Laboratory | STJ111190 | Polyclonal |
WB
ICC
IP
IHC
ChIP
|
||
Proteintech Group | 66969-1-Ig | 1 references | Monoclonal |
WB
EL
IHC
|
|
Atlas Antibodies | HPA036469 | Polyclonal |
WB
IHC |
||
LSBio | LS-C789586 | Monoclonal |
WB
IHC |
||
Biorbyt | orb156626 | Polyclonal |
WB
EL
ICC
IHC |
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider