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- Antibody Data
- Antigen structure
- References [26]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 18443-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18443-1-AP, RRID:AB_10699875
- Product name
- UQCRFS1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated UQCRFS1 antibody (Cat. #18443-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Angiotensin-(1-7) Modulates the Warburg Effect to Alleviate Inflammation in LPS-Induced Macrophages and Septic Mice.
Deficient tRNA posttranscription modification dysregulated the mitochondrial quality controls and apoptosis.
Transcriptomics and metabolomics study in mouse kidney of the molecular mechanism underlying energy metabolism response to hypoxic stress in highland areas.
Hinokitiol-iron complex is a ferroptosis inducer to inhibit triple-negative breast tumor growth.
Contemporary Antiretroviral Therapy Dysregulates Iron Transport and Augments Mitochondrial Dysfunction in HIV-Infected Human Microglia and Neural-Lineage Cells.
Stimulation of Hepatic Ferritinophagy Mitigates Irp2 Depletion-Induced Anemia.
Phenotypic profiling of solute carriers characterizes serine transport in cancer.
Relation of Plasma Catecholamine Concentrations and Myocardial Mitochondrial Respiratory Activity in Anesthetized and Mechanically Ventilated, Cardiovascular Healthy Swine.
Human TRUB1 is a highly conserved pseudouridine synthase responsible for the formation of Ψ55 in mitochondrial tRNAAsn, tRNAGln, tRNAGlu and tRNAPro.
Cur@SF NPs alleviate Friedreich's ataxia in a mouse model through synergistic iron chelation and antioxidation.
MyD88 deficiency ameliorates weight loss caused by intestinal oxidative injury in an autophagy-dependent mechanism.
The Protective Effect of 1,25(OH)(2)D(3) on Myocardial Function is Mediated via Sirtuin 3-Regulated Fatty Acid Metabolism.
Protective Effects of Hif2 Inhibitor PT-2385 on a Neurological Disorder Induced by Deficiency of Irp2.
SS-31 efficacy in a mouse model of Friedreich ataxia by upregulation of frataxin expression.
Mcl-1-mediated mitochondrial fission protects against stress but impairs cardiac adaptation to exercise.
SR18292 exerts potent antitumor effects in multiple myeloma via inhibition of oxidative phosphorylation.
Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells.
NDUFAB1 confers cardio-protection by enhancing mitochondrial bioenergetics through coordination of respiratory complex and supercomplex assembly.
NDUFAB1 protects against obesity and insulin resistance by enhancing mitochondrial metabolism.
Extensive skeletal muscle cell mitochondriopathy distinguishes critical limb ischemia patients from claudicants.
Iron regulatory protein deficiency compromises mitochondrial function in murine embryonic fibroblasts.
NDUFA9 point mutations cause a variable mitochondrial complex I assembly defect.
Mutation in mitochondrial complex IV subunit COX5A causes pulmonary arterial hypertension, lactic acidemia, and failure to thrive.
CYC1 Predicts Poor Prognosis in Patients with Breast Cancer.
EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.
Trichostatin A targets the mitochondrial respiratory chain, increasing mitochondrial reactive oxygen species production to trigger apoptosis in human breast cancer cells.
Yu D, Huang W, Sheng M, Zhang S, Pan H, Ren F, Luo L, Zhou J, Huang D, Tang L
Journal of inflammation research 2024;17:469-485
Journal of inflammation research 2024;17:469-485
Deficient tRNA posttranscription modification dysregulated the mitochondrial quality controls and apoptosis.
He Y, Zhu G, Li X, Zhou M, Guan MX
iScience 2024 Feb 16;27(2):108883
iScience 2024 Feb 16;27(2):108883
Transcriptomics and metabolomics study in mouse kidney of the molecular mechanism underlying energy metabolism response to hypoxic stress in highland areas.
Gao Y, Long Q, Yang H, Hu Y, Xu Y, Tang C, Gu C, Yong S
Experimental and therapeutic medicine 2023 Nov;26(5):533
Experimental and therapeutic medicine 2023 Nov;26(5):533
Hinokitiol-iron complex is a ferroptosis inducer to inhibit triple-negative breast tumor growth.
Zhao H, Zhang M, Zhang J, Sun Z, Zhang W, Dong W, Cheng C, Yao Y, Li K
Cell & bioscience 2023 May 13;13(1):87
Cell & bioscience 2023 May 13;13(1):87
Contemporary Antiretroviral Therapy Dysregulates Iron Transport and Augments Mitochondrial Dysfunction in HIV-Infected Human Microglia and Neural-Lineage Cells.
Kaur H, Minchella P, Alvarez-Carbonell D, Purandare N, Nagampalli VK, Blankenberg D, Hulgan T, Gerschenson M, Karn J, Aras S, Kallianpur AR
International journal of molecular sciences 2023 Jul 31;24(15)
International journal of molecular sciences 2023 Jul 31;24(15)
Stimulation of Hepatic Ferritinophagy Mitigates Irp2 Depletion-Induced Anemia.
Liu Y, Li Y, Yang L, Shen J, Zhao H, Dong W, Chang Y, Qiao T, Li K
Antioxidants (Basel, Switzerland) 2023 Feb 24;12(3)
Antioxidants (Basel, Switzerland) 2023 Feb 24;12(3)
Phenotypic profiling of solute carriers characterizes serine transport in cancer.
Papalazarou V, Newman AC, Huerta-Uribe A, Legrave NM, Falcone M, Zhang T, McGarry L, Athineos D, Shanks E, Blyth K, Vousden KH, Maddocks ODK
Nature metabolism 2023 Dec;5(12):2148-2168
Nature metabolism 2023 Dec;5(12):2148-2168
Relation of Plasma Catecholamine Concentrations and Myocardial Mitochondrial Respiratory Activity in Anesthetized and Mechanically Ventilated, Cardiovascular Healthy Swine.
Abele N, Münz F, Zink F, Gröger M, Hoffmann A, Wolfschmitt EM, Hogg M, Calzia E, Waller C, Radermacher P, Merz T
International journal of molecular sciences 2023 Dec 9;24(24)
International journal of molecular sciences 2023 Dec 9;24(24)
Human TRUB1 is a highly conserved pseudouridine synthase responsible for the formation of Ψ55 in mitochondrial tRNAAsn, tRNAGln, tRNAGlu and tRNAPro.
Jia Z, Meng F, Chen H, Zhu G, Li X, He Y, Zhang L, He X, Zhan H, Chen M, Ji Y, Wang M, Guan MX
Nucleic acids research 2022 Sep 9;50(16):9368-9381
Nucleic acids research 2022 Sep 9;50(16):9368-9381
Cur@SF NPs alleviate Friedreich's ataxia in a mouse model through synergistic iron chelation and antioxidation.
Xu L, Sun Z, Xing Z, Liu Y, Zhao H, Tang Z, Luo Y, Hao S, Li K
Journal of nanobiotechnology 2022 Mar 9;20(1):118
Journal of nanobiotechnology 2022 Mar 9;20(1):118
MyD88 deficiency ameliorates weight loss caused by intestinal oxidative injury in an autophagy-dependent mechanism.
Qi M, Liao S, Wang J, Deng Y, Zha A, Shao Y, Cui Z, Song T, Tang Y, Tan B, Yin Y
Journal of cachexia, sarcopenia and muscle 2022 Feb;13(1):677-695
Journal of cachexia, sarcopenia and muscle 2022 Feb;13(1):677-695
The Protective Effect of 1,25(OH)(2)D(3) on Myocardial Function is Mediated via Sirtuin 3-Regulated Fatty Acid Metabolism.
Yang J, Zhang Y, Pan Y, Sun C, Liu Z, Liu N, Fu Y, Li X, Li Y, Kong J
Frontiers in cell and developmental biology 2021;9:627135
Frontiers in cell and developmental biology 2021;9:627135
Protective Effects of Hif2 Inhibitor PT-2385 on a Neurological Disorder Induced by Deficiency of Irp2.
Shen J, Xu L, Li Y, Dong W, Cai J, Liu Y, Zhao H, Xu T, Holtz EM, Chang Y, Qiao T, Li K
Frontiers in neuroscience 2021;15:715222
Frontiers in neuroscience 2021;15:715222
SS-31 efficacy in a mouse model of Friedreich ataxia by upregulation of frataxin expression.
Liu Y, Cai J, Shen J, Dong W, Xu L, Fang M, Lin Y, Liu J, Ding Y, Qiao T, Li K
Human molecular genetics 2021 Dec 27;31(2):176-188
Human molecular genetics 2021 Dec 27;31(2):176-188
Mcl-1-mediated mitochondrial fission protects against stress but impairs cardiac adaptation to exercise.
Moyzis AG, Lally NS, Liang W, Leon LJ, Najor RH, Orogo AM, Gustafsson ÅB
Journal of molecular and cellular cardiology 2020 Sep;146:109-120
Journal of molecular and cellular cardiology 2020 Sep;146:109-120
SR18292 exerts potent antitumor effects in multiple myeloma via inhibition of oxidative phosphorylation.
Xiang Y, Fang B, Liu Y, Yan S, Cao D, Mei H, Wang Q, Hu Y, Guo T
Life sciences 2020 Sep 1;256:117971
Life sciences 2020 Sep 1;256:117971
Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells.
Jing J, Ding N, Wang D, Ge X, Ma J, Ma R, Huang X, Jueraitetibaike K, Liang K, Wang S, Cao S, Zhao AZ, Yao B
Cell death & disease 2020 Aug 14;11(8):626
Cell death & disease 2020 Aug 14;11(8):626
NDUFAB1 confers cardio-protection by enhancing mitochondrial bioenergetics through coordination of respiratory complex and supercomplex assembly.
Hou T, Zhang R, Jian C, Ding W, Wang Y, Ling S, Ma Q, Hu X, Cheng H, Wang X
Cell research 2019 Sep;29(9):754-766
Cell research 2019 Sep;29(9):754-766
NDUFAB1 protects against obesity and insulin resistance by enhancing mitochondrial metabolism.
Zhang R, Hou T, Cheng H, Wang X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Dec;33(12):13310-13322
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Dec;33(12):13310-13322
Extensive skeletal muscle cell mitochondriopathy distinguishes critical limb ischemia patients from claudicants.
Ryan TE, Yamaguchi DJ, Schmidt CA, Zeczycki TN, Shaikh SR, Brophy P, Green TD, Tarpey MD, Karnekar R, Goldberg EJ, Sparagna GC, Torres MJ, Annex BH, Neufer PD, Spangenburg EE, McClung JM
JCI insight 2018 Nov 2;3(21)
JCI insight 2018 Nov 2;3(21)
Iron regulatory protein deficiency compromises mitochondrial function in murine embryonic fibroblasts.
Li H, Zhao H, Hao S, Shang L, Wu J, Song C, Meyron-Holtz EG, Qiao T, Li K
Scientific reports 2018 Mar 23;8(1):5118
Scientific reports 2018 Mar 23;8(1):5118
NDUFA9 point mutations cause a variable mitochondrial complex I assembly defect.
Baertling F, Sánchez-Caballero L, van den Brand MAM, Fung CW, Chan SH, Wong VC, Hellebrekers DME, de Coo IFM, Smeitink JAM, Rodenburg RJT, Nijtmans LGJ
Clinical genetics 2018 Jan;93(1):111-118
Clinical genetics 2018 Jan;93(1):111-118
Mutation in mitochondrial complex IV subunit COX5A causes pulmonary arterial hypertension, lactic acidemia, and failure to thrive.
Baertling F, Al-Murshedi F, Sánchez-Caballero L, Al-Senaidi K, Joshi NP, Venselaar H, van den Brand MA, Nijtmans LG, Rodenburg RJ
Human mutation 2017 Jun;38(6):692-703
Human mutation 2017 Jun;38(6):692-703
CYC1 Predicts Poor Prognosis in Patients with Breast Cancer.
Han Y, Sun S, Zhao M, Zhang Z, Gong S, Gao P, Liu J, Zhou J, Ma D, Gao Q, Wu P
Disease markers 2016;2016:3528064
Disease markers 2016;2016:3528064
EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.
Zhang J, Wang C, Chen X, Takada M, Fan C, Zheng X, Wen H, Liu Y, Wang C, Pestell RG, Aird KM, Kaelin WG Jr, Liu XS, Zhang Q
The EMBO journal 2015 Dec 2;34(23):2953-70
The EMBO journal 2015 Dec 2;34(23):2953-70
Trichostatin A targets the mitochondrial respiratory chain, increasing mitochondrial reactive oxygen species production to trigger apoptosis in human breast cancer cells.
Sun S, Han Y, Liu J, Fang Y, Tian Y, Zhou J, Ma D, Wu P
PloS one 2014;9(3):e91610
PloS one 2014;9(3):e91610
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse ovary tissue were subjected to SDS PAGE followed by western blot with 18443-1-AP(UQCRFS1 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The UQCRFS1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human UQCRFS1. This antibody recognizes human,mouse,rat antigen. The UQCRFS1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
