66514-1-Ig

antibody from Proteintech Group

Targeting: USP7 HAUSP

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

66514-1-Ig

Provider

Proteintech Group

Product name

USP7 antibody

Antibody type

Monoclonal

Description

USP7 antibody (Cat. #66514-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, rat, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

3D7D11

Vial size

20ul, 150ul

References

Submitted references

Potential Anti-Cancer Drug 6RK73 Suppresses Ovarian Cancer Growth by Inactivating the AKT1/Sp1 Induced c-Myc Signaling Pathway.

Kuang S, Feng W, He S, Meng W, Yang C, Ning Y
Journal of Cancer 2026;17(2):245-256

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Suppression of LRRC41-mediated oncogenicity in hepatocellular carcinoma via USP7-targeted small molecule inhibitors.

Huang Y, Xi Y, Nie H, Wang Y, Hu J, Gao Y, Li J, Ma Y, Chu J, Tu L, Huang D, Cheng L
British journal of cancer 2026 Jun;134(11):1658-1670

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The NPC1/USP7/p53 axis regulates cholesterol and promotes the proliferation of hepatocellular carcinoma.

Deng R, Zheng X, Liu F, Gao J, Wang S, Yun J, Wang F, Li Y, Ai X, Liu Y
Oncogene 2026 Apr;45(15):1386-1397

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USP7-stabilized CEBPB promotes HpSCC progression by upregulating IL6 to activate the JAK2/STAT3 signaling.

Li H, Fan R, Qu Y, Shao Y, Bai Y, Xu C, Hu J, Zhang X
Molecular and cellular biochemistry 2026 Apr 28;

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Overexpression of miR-7641 activates ox-LDL-induced autophagy in macrophages by regulating USP7.

Tian P, Du Q, Zeng F, Chen J, Wang P, Zhang L, Li Y
Molecular biology reports 2026 Apr 22;53(1)

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RNF2 Modulates Lipid Metabolism and Inflammation in Alcohol-associated Liver Disease by Interacting with USP7.

Yan Q, Fang Q, Chen Z, Chen L, Du J
International journal of biological sciences 2025;21(7):3306-3323

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NDR1 enhances USP9X-mediated AR deubiquitination and promotes enzalutamide resistance in castration-resistant prostate cancer.

Zheng Z, Li J, Du Y, Li L, Wu Q, Liu B, Wu H, Zhang Z, Xuan Z, Zhao Y, Sun H, Shao C
International journal of biological sciences 2025;21(13):5628-5644

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Tetrahydrocurcumin targets TRIP13 inhibiting the interaction of TRIP13/USP7/c-FLIP to mediate c-FLIP ubiquitination in triple-negative breast cancer.

Sun YJ, Zhang Q, Cao SJ, Sun XH, Zhang JC, Zhang BY, Shang ZB, Zhao CY, Cao ZY, Zhang QJ, Gao XM, Qiu F, Kang N
Journal of advanced research 2025 Sep;75:591-605

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Deubiquitination by USP7 Stabilizes JunD and Activates AIFM2 (FSP1) to Inhibit Ferroptosis in Melanoma.

Xie J, Ma C, Zhao S, Wu D, Zhang P, Tang Q, Ni T, Yan W, Qi M
The Journal of investigative dermatology 2025 Oct;145(10):2562-2575.e5

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Acetylation-dependent USP7-TRIM25 axis drives oncogenic progression in non-small cell lung cancer.

Yang J, Chen Z, Hu W, Zeng W, Lei Z, Tong X, Li Q, Luo G, Hu K, Chen Z, Liu Z, Li C, Xu C, Ding C, Zhang HT, Zhao J
Cell death & disease 2025 Oct 6;16(1):695

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The CTLH ubiquitin ligase substrates ZMYND19 and MKLN1 negatively regulate mTORC1 at the lysosomal membrane.

Wang Y, Liao Y, Sun Y, Mitra B, Guo R, Piedras BI, White S, Tang HY, Asara JM, Tempera I, Lieberman PM, Gewurz BE
Nature communications 2025 Nov 28;16(1):10731

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Synergistic regulation of DACH1 stability by acetylation and deubiquitination promotes colorectal cancer progression.

Zhu L, Cheng C, Li H, Liu J, Wu Y, Wu L, Yao H
Cell death & disease 2025 May 19;16(1):400

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Redox-Induced Stabilization of AMBRA1 by USP7 Promotes Intestinal Oxidative Stress and Colitis Through Antagonizing DUB3-Mediated NRF2 Deubiquitination.

Xu W, Hua Z, Wang Y, Tang W, Ge W, Chen Y, Wang Z, Gu Y, Liu CY, Du P
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(12):e2411320

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The potential value of microRNA-409-5p-mediated negative regulation of USP7 in the diagnosis and treatment of acute myocardial infarction.

Fu X, Zhang X, Wang L, Zhang J, Li W, Qin S, Zhang M, Zheng X, Li Y, Yang S, Xue Q
BMC cardiovascular disorders 2025 Mar 8;25(1):167

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Role of the USP7/FOXO3A axis in environmentally relevant doses of arsenic-induced lung carcinogenesis: Insights from bioinformatics analysis and model of human epithelial cell malignant transformation.

Chen X, Wang Y, Liu Z, He Y, Gao H, Guan X, Chen L, Chen S, Xing X, Chen W, Li D, Wang Q
Ecotoxicology and environmental safety 2025 Jun 1;297:118224

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USP7 facilitates deubiquitination of LRRC42 in colorectal cancer to accelerate tumorigenesis and augment Wnt/β-catenin signaling.

Li Y, Sun X, Huang Z
Biochimica et biophysica acta. Molecular cell research 2025 Jan;1872(1):119859

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MLKL-USP7-UBA52 signaling is indispensable for autophagy in brain through maintaining ubiquitin homeostasis.

Zhang Z, Chen S, Jun S, Xu X, Hong Y, Yang X, Zou L, Song YQ, Chen Y, Tu J
Autophagy 2025 Feb;21(2):424-446

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Monocyte USP7-p65 axis mediates immune responses to the immunogenicity of nucleus pulposus.

Feng P, Chu X, Che Y, Gao J, Gao C, Zhang T
Cell stress & chaperones 2025 Dec;30(6):100114

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LRRC1 Promotes Angiogenesis Through Regulating AKT/GSK3β/β-Catenin/VEGFA Signaling Pathway in Hepatocellular Carcinoma.

Liu H, Liu Z, Xie P, Liu Z, Zhang Y, Cao L, Shang N, Chen M, Feng H, Guan X, Dai G
Cells 2025 Dec 3;14(23)

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Immune-related deubiquitylation spectrum of microsatellite stability colorectal cancer reveals USP7 as a potential immunotherapeutic target.

Yin X, Wu J, Xu MD, Tian T, Zhu L, Wang J, Dai X, Yang X, Qian J, Wang W, Zhu L, Zhao Z, Xu K, Xu Y, Li X, Hu Z
Molecular cancer 2025 Dec 18;25(1)

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Circulating metabolomics reveals guanosine monophosphate synthetase (GMPS) as a novel therapeutic target in lung adenocarcinoma.

Yu M, Yang D, Zhu D, Wang Y, Cao M, Zhu J, Zhu W, Wang G, Aa J
The Journal of pathology 2025 Aug;266(4-5):465-480

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Reduction of lymphotoxin beta receptor induces cellular senescence via the MDMX-p53 pathway.

Kim SY, Lee B, Lee JJ, Kwak MS, Rhee WJ, Park IH, Shin JS
Cell death discovery 2025 Aug 29;11(1):416

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USP7 promotes endothelial activation to aggravate sepsis-induced acute lung injury through PDK1/AKT/NF-κB signaling pathway.

Liu Z, Shi X, Ke T, Yan Z, Xiong L, Tang F
Cell death discovery 2025 Apr 17;11(1):183

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TMEM43 promotes the development of hepatocellular carcinoma by activating VDAC1 through USP7 deubiquitination.

Zhang N, Wang F, Yang X, Wang Q, Chang R, Zhu L, Feitelson MA, Chen Z
Translational gastroenterology and hepatology 2024;9:9

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USP7 deubiquitinates epigenetic reader ZMYND8 to promote breast cancer cell migration and invasion.

Tang K, Yin T, Deng B, Wang M, Ren Z, Wang S, Liu X, Li H, Wang J, Du Y, Zhou J, Chen Y, Wang Y
The Journal of biological chemistry 2024 Sep;300(9):107672

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The Long Non-Coding RNA NR3C2-8:1 Promotes p53-Mediated Apoptosis through the miR-129-5p/USP10 Axis in Amyotrophic Lateral Sclerosis.

Pang D, Yu Y, Zhao B, Huang J, Cui Y, Li T, Li C, Shang H
Molecular neurobiology 2024 Oct;61(10):7466-7480

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Mitochondrial-Derived Peptide MOTS-c Suppresses Ovarian Cancer Progression by Attenuating USP7-Mediated LARS1 Deubiquitination.

Yin Y, Li Y, Ma B, Ren C, Zhao S, Li J, Gong Y, Yang H, Li J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(43):e2405620

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The deubiquitinase USP7 and E3 ligase TRIM21 regulate vasculogenic mimicry and malignant progression of RMS by balancing SNAI2 homeostasis.

Zhang R, Zhang D, Han F, Song X, Zhang Y, Zhang J, Zhu Q, Qin Y
Journal of experimental & clinical cancer research : CR 2024 May 4;43(1):135

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The role of USP7-YY1 interaction in promoting colorectal cancer growth and metastasis.

Shao ZY, Yang WD, Qiu H, He ZH, Lu MR, Shen Q, Ding J, Zheng JN, Bai J
Cell death & disease 2024 May 20;15(5):347

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Identification of mechanism of the oncogenic role of FGFR1 in papillary thyroid carcinoma.

Li XB, Li JL, Wang C, Zhang Y, Li J
European journal of histochemistry : EJH 2024 Jul 22;68(3)

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Guanosine diphosphate-mannose suppresses homologous recombination repair and potentiates antitumor immunity in triple-negative breast cancer.

Ding JH, Xiao Y, Yang F, Song XQ, Xu Y, Ding XH, Ding R, Shao ZM, Di GH, Jiang YZ
Science translational medicine 2024 Jan 3;16(728):eadg7740

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Stabilization of KPNB1 by deubiquitinase USP7 promotes glioblastoma progression through the YBX1-NLGN3 axis.

Li J, Zhang B, Feng Z, An D, Zhou Z, Wan C, Hu Y, Sun Y, Wang Y, Liu X, Wei W, Yang X, Meng J, Che M, Sheng Y, Wu B, Wen L, Huang F, Li Y, Yang K
Journal of experimental & clinical cancer research : CR 2024 Jan 23;43(1):28

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CRIP1 involves the pathogenesis of multiple myeloma via dual-regulation of proteasome and autophagy.

Tang P, Yu Z, Sun H, Liu L, Gong L, Fang T, Sun X, Xie S, An G, Xu Z, Qiu L, Hao M
EBioMedicine 2024 Feb;100:104961

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A TOPBP1 allele causing male infertility uncouples XY silencing dynamics from sex body formation.

Ascenção C, Sims JR, Dziubek A, Comstock W, Fogarty EA, Badar J, Freire R, Grimson A, Weiss RS, Cohen PE, Smolka MB
eLife 2024 Feb 23;12

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Inhibition of ubiquitin-specific protease 7 ameliorates ferroptosis-mediated myocardial infarction by contrasting oxidative stress: An in vitro and in vivo analysis.

Yang D, Zhang T, Qu H, Li S, Lu J, Cao W, Chen Z, Zhang H, Yang J, Wang J
Cellular signalling 2024 Dec;124:111423

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The CTLH Ubiquitin Ligase Substrates ZMYND19 and MKLN1 Negatively Regulate mTORC1 at the Lysosomal Membrane.

Wang Y, Guo R, Piedras BI, Tang HY, Asara JM, Tempera I, Lieberman PM, Gewurz BE
Research square 2024 Apr 24;

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USP7 reduction leads to developmental failure of mouse early embryos.

Zhang X, Xie XF, Li A, Song W, Li C, Li F, Li XZ, Fan XY, Zhou CY, Wang G, Sun QY, Ou XH
Experimental cell research 2023 Jun 15;427(2):113605

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Metabolite asymmetric dimethylarginine (ADMA) functions as a destabilization enhancer of SOX9 mediated by DDAH1 in osteoarthritis.

Wu Y, Shen S, Chen J, Ni W, Wang Q, Zhou H, Chen J, Zhang H, Mei Z, Sun X, Shen P, Jie Z, Xu W, Hong Z, Ma Y, Wang K, Wan S, Wu H, Xie Z, Qin A, Fan S
Science advances 2023 Feb 10;9(6):eade5584

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Increased degradation of FMRP contributes to neuronal hyperexcitability in tuberous sclerosis complex.

Winden KD, Pham TT, Teaney NA, Ruiz J, Chen R, Chen C, Sahin M
Cell reports 2023 Aug 29;42(8):112838

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The deubiquitinase USP7 regulates oxidative stress through stabilization of HO-1.

Gao M, Qi Z, Deng M, Huang H, Xu Z, Guo G, Jing J, Huang X, Xu M, Kloeber JA, Liu S, Huang J, Lou Z, Han J
Oncogene 2022 Aug;41(33):4018-4027

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Indirubin-3'-monoxime acts as proteasome inhibitor: Therapeutic application in multiple myeloma.

Yu Z, Wei X, Liu L, Sun H, Fang T, Wang L, Li Y, Sui W, Wang K, He Y, Zhao Y, Huang W, An G, Meng F, Huang C, Yu T, Anderson KC, Cheng T, Qiu L, Hao M
EBioMedicine 2022 Apr;78:103950

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Deubiquitination of FBP1 by USP7 blocks FBP1-DNMT1 interaction and decreases the sensitivity of pancreatic cancer cells to PARP inhibitors.

Cheng X, Zhang B, Guo F, Wu H, Jin X
Molecular oncology 2022 Apr;16(7):1591-1607

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The role of USP7 in the Shoc2-ERK1/2 signaling axis and Noonan-like syndrome with loose anagen hair.

Wilson P, Abdelmoti L, Norcross R, Jang ER, Palayam M, Galperin E
Journal of cell science 2021 Nov 1;134(21)

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BK Channel Deficiency in Osteoblasts Reduces Bone Formation via the Wnt/β-Catenin Pathway.

Jiang L, Yang Q, Gao J, Yang J, He J, Xin H, Zhang X
Molecules and cells 2021 Aug 31;44(8):557-568

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TRIM21-SERPINB5 aids GMPS repression to protect nasopharyngeal carcinoma cells from radiation-induced apoptosis.

Zhang P, Li X, He Q, Zhang L, Song K, Yang X, He Q, Wang Y, Hong X, Ma J, Liu N
Journal of biomedical science 2020 Jan 31;27(1):30