Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- BS6781 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- SLC22A6 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human SLC22A6.
- Description
- The organic anion transporter (OAT) family of proteins mediate the secretion of exogenous and endogenous levels of metabolites from tissues throughout the body. OAT1 (organic anion transporter 1), a 563 amino acid protein, and OAT3 (organic anion transporter 3), a 542 amino acid protein, are two members of the OAT family and are highly expressed in kidneys. Localized specifically to the basolateral membrane, OAT1 and OAT3 are involved in the elimination of toxic organic anions, such as benzylpenicillin and cimetidine, from proximal renal tubules. Via their ability to remove anions from renal tissues, OAT1 and OAT3 are able to regulate the amount of toxins within the kidneys. Additionally, OAT1 functions as an organic anion exchanger that couples the uptake of one organic anion molecule with the efflux of one endogenous levels of dicarboxylic acid molecule, such as ketoglutarate. Four isoforms of OAT1 and three isoforms of OAT3 are expressed due to alternative splicing events.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
No comments: Submit comment
Supportive validation
- Submitted by
- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot analysis of extracts of CEM cell lines, using SLC22A6 antibody.