Antibody data
- Antibody Data
- Antigen structure
- References [38]
- Comments [0]
- Validations [0]
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- Product number
- 26574-1-AP - Provider product page

- Provider
- Proteintech Group
- Product name
- OAT1 antibody
- Antibody type
- Polyclonal
- Description
- OAT1 antibody (Cat. #26574-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Lithocarpus litseifolius leaf extract alleviate hyperuricemia-induced renal injury by regulating uric acid metabolism and inhibiting the AKT/S6K pathway.
Lactiplantibacillus pentosus JWN01 and Lactiplantibacillus plantarum JWN02 attenuate renal fibrosis and pathological autophagy in hyperuricemic nephropathy via gut-kidney axis.
Huazhuo Sanjie Chubi Decoction attenuates gouty arthritis and kidney fibrosis by regulating urate transporters and JAK2/STAT3 pathway.
Wuling capsule alleviates hyperuricaemia and protects UA- injured HK-2 cells by regulating uric acid transporter proteins.
A strategy for evaluating the impact of processing of Chinese meteria medica on meridian tropism: the influence of salt-water processing of phellodendri chinensis cortex on renal transport proteins.
Effect and mechanism of Plantaginis Semen polysaccharides on intestinal microecology in rats with hyperuricemia.
Cyclocarya paliurus polysaccharides alleviate hyperuricemia in mice by regulating gut microbiota to enhance uric acid excretion.
Urolithin C Ameliorates Hyperuricemia by Mitigating Renal Dysfunction through ROS-p38/ERK MAPK Axis Suppression.
Secoisolariciresinol diglucoside (SDG) from flaxseed meal alleviates hyperuricemia in mice by regulating uric acid metabolism and intestinal homeostasis.
Brain-derived extracellular vesicles circUsp32 polarized macrophages causing acute kidney injury after traumatic brain injury.
The inhibitory effect of Astragalus flavone extract on hyperuricemia and its underlying molecular mechanism by targeting JNK/AP-1/NLRP3/IL-1β signaling pathway.
Adipocyte-derived glutathione promotes obesity-related breast cancer by regulating the SCARB2-ARF1-mTORC1 complex.
The Urate-Lowering Effects and Renal Protective Activity of Iridoid Glycosides from Paederia foetida in Rats with Hyperuricemia-Induced Kidney Injury: A Pharmacological and Molecular Docking Study.
Anti-hyperuricemic effects of the seeds of Hovenia acerba in hyperuricemia mice.
Pax proteins mediate segment-specific functions in proximal tubule survival and response to ischemic injury.
Multi-strategy profiling identifies limonin's dual role in gout: restoring uric acid homeostasis and suppressing inflammatory response.
Antihyperuricemic, hepatoprotective and nephroprotective roles of Benincasae Exocarpium in hyperuricemia rats.
Pediococcus acidilactici GR-5 alleviates hyperuricemia by degrading purine nucleosides and improving gut microbiota metabolism.
Chuanxiong Rhizoma extracts alleviate hyperuricaemia-induced renal injury by reducing serum UA levels and renoprotection.
Korean Red Ginseng Ameliorates the Level of Serum Uric Acid via Downregulating URAT1 and Upregulating OAT1 and OAT3.
Lactiplantibacillus plantarum 06CC2 Enhanced the Expression of Intestinal Uric Acid Excretion Transporter in Mice.
Sustained alterations in proximal tubule gene expression in primary culture associate with HNF4A loss.
Metabolic Communication by SGLT2 Inhibition.
Analyzing chemical composition of Sargentodoxae caulis water extract and their hypouricemia effect in hyperuricemic mice.
Fuling-Zexie formula attenuates hyperuricemia-induced nephropathy and inhibits JAK2/STAT3 signaling and NLRP3 inflammasome activation in mice.
Data mining-guided alleviation of hyperuricemia by Paeonia veitchii Lynch through inhibition of xanthine oxidase and regulation of renal urate transporters.
SGLT2 inhibitor dapagliflozin protects the kidney in a murine model of Balkan nephropathy.
The SGLT2 inhibitor dapagliflozin ameliorates renal fibrosis in hyperuricemic nephropathy.
Paeonia × suffruticosa Andrews leaf extract and its main component apigenin 7-O-glucoside ameliorate hyperuricemia by inhibiting xanthine oxidase activity and regulating renal urate transporters.
Amelioration effects of α-viniferin on hyperuricemia and hyperuricemia-induced kidney injury in mice.
Inhibition of Transforming Growth Factor-β Improves Primary Renal Tubule Cell Differentiation in Long-Term Culture.
Sanghuangporus vaninii ethanol extract alleviates hyperuricemic renal injury by regulating the uric acid transporters and inhibiting HK-2 apoptosis.
Simiao San alleviates hyperuricemia and kidney inflammation by inhibiting NLRP3 inflammasome and JAK2/STAT3 signaling in hyperuricemia mice.
Therapeutic effects and mechanisms of N-(9,10-anthraquinone-2-ylcarbonyl) xanthine oxidase inhibitors on hyperuricemia.
Apigenin Ameliorates Hyperuricemia and Renal Injury through Regulation of Uric Acid Metabolism and JAK2/STAT3 Signaling Pathway.
Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms.
Berberrubine attenuates potassium oxonate- and hypoxanthine-induced hyperuricemia by regulating urate transporters and JAK2/STAT3 signaling pathway.
Active components from Lagotis brachystachya maintain uric acid homeostasis by inhibiting renal TLR4-NLRP3 signaling in hyperuricemic mice.
Yang W, Gui R, Liu Y, Zou H, Xiao L, Deng G, Wan Z, Yu X, Feng X, Long H, Wang Y, Li D, He X, Xu K
Journal of ethnopharmacology 2026 May 10;362:121362
Journal of ethnopharmacology 2026 May 10;362:121362
Lactiplantibacillus pentosus JWN01 and Lactiplantibacillus plantarum JWN02 attenuate renal fibrosis and pathological autophagy in hyperuricemic nephropathy via gut-kidney axis.
Mo Q, Qin M, Liang H, Wei L, Li Y, Qin Y, Tang L, Liang J, Qian C, Liang Y, Luo S, Wei Y, Kong L, Cheng J
Food research international (Ottawa, Ont.) 2026 Mar 31;228:118376
Food research international (Ottawa, Ont.) 2026 Mar 31;228:118376
Huazhuo Sanjie Chubi Decoction attenuates gouty arthritis and kidney fibrosis by regulating urate transporters and JAK2/STAT3 pathway.
Zhong X, Lin S, Zhong M, Zhang Z, Chen X, Guo J, Chen P, Zheng Y, Huang M, Su Y
Journal of ethnopharmacology 2026 Jan 10;354:120457
Journal of ethnopharmacology 2026 Jan 10;354:120457
Wuling capsule alleviates hyperuricaemia and protects UA- injured HK-2 cells by regulating uric acid transporter proteins.
Li N, Liu H, Song Z, Zhou R, Tang Z, Xu H, Shi X, Liu Y, Ni J
Frontiers in pharmacology 2025;16:1563676
Frontiers in pharmacology 2025;16:1563676
A strategy for evaluating the impact of processing of Chinese meteria medica on meridian tropism: the influence of salt-water processing of phellodendri chinensis cortex on renal transport proteins.
Chen Y, Zhang F, Ren W, Zhou Y, Jiang S, Zhang S, Xu G, Ge X, Gao H
Frontiers in pharmacology 2025;16:1558298
Frontiers in pharmacology 2025;16:1558298
Effect and mechanism of Plantaginis Semen polysaccharides on intestinal microecology in rats with hyperuricemia.
Zhao J, Fu Y, Qiu H
Frontiers in microbiology 2025;16:1555734
Frontiers in microbiology 2025;16:1555734
Cyclocarya paliurus polysaccharides alleviate hyperuricemia in mice by regulating gut microbiota to enhance uric acid excretion.
Cao Y, Hu W, Yu C, Chen L, Chen H, Lin S, Wang D, Wang W
International journal of biological macromolecules 2025 Sep;322(Pt 4):147029
International journal of biological macromolecules 2025 Sep;322(Pt 4):147029
Urolithin C Ameliorates Hyperuricemia by Mitigating Renal Dysfunction through ROS-p38/ERK MAPK Axis Suppression.
Han Q, Chen N, Peng K, Wang M, Chen M, Mamadalieva NZ, Zhang Y, Liu C, Ren Q
Journal of agricultural and food chemistry 2025 Sep 10;73(36):22485-22501
Journal of agricultural and food chemistry 2025 Sep 10;73(36):22485-22501
Secoisolariciresinol diglucoside (SDG) from flaxseed meal alleviates hyperuricemia in mice by regulating uric acid metabolism and intestinal homeostasis.
Wang S, Chen J, Li Y, Wang Y
Food research international (Ottawa, Ont.) 2025 Oct;217:116770
Food research international (Ottawa, Ont.) 2025 Oct;217:116770
Brain-derived extracellular vesicles circUsp32 polarized macrophages causing acute kidney injury after traumatic brain injury.
Fu J, Wu J, Du M, Wang X, Shi Q, Fang Y, Lan Y, Wu Q, Zhang G, Xu L, Yan H
Science advances 2025 Nov 28;11(48):eadz1243
Science advances 2025 Nov 28;11(48):eadz1243
The inhibitory effect of Astragalus flavone extract on hyperuricemia and its underlying molecular mechanism by targeting JNK/AP-1/NLRP3/IL-1β signaling pathway.
Xia H, He W, Lv C, Zhang J, Lin X, Qin S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156622
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156622
Adipocyte-derived glutathione promotes obesity-related breast cancer by regulating the SCARB2-ARF1-mTORC1 complex.
Zhao C, Zhang T, Xue ST, Zhang P, Wang F, Li Y, Liu Y, Zhao L, Wu J, Yan Y, Mao X, Chen Y, Yuan J, Li Z, Li K
Cell metabolism 2025 Mar 4;37(3):692-707.e9
Cell metabolism 2025 Mar 4;37(3):692-707.e9
The Urate-Lowering Effects and Renal Protective Activity of Iridoid Glycosides from Paederia foetida in Rats with Hyperuricemia-Induced Kidney Injury: A Pharmacological and Molecular Docking Study.
Zhou H, Yue X, Shen L, Wu L, Li X, Wu T
Molecules (Basel, Switzerland) 2025 Jul 24;30(15)
Molecules (Basel, Switzerland) 2025 Jul 24;30(15)
Anti-hyperuricemic effects of the seeds of Hovenia acerba in hyperuricemia mice.
Wang Y, Liao X, Zhang J, Yang Y, Gao Y, Zhang C, Guo X, Zhu Q, Li J, Yu L, Xu G, Fang X, Liao SG
Journal of ethnopharmacology 2025 Jan 31;340:119215
Journal of ethnopharmacology 2025 Jan 31;340:119215
Pax proteins mediate segment-specific functions in proximal tubule survival and response to ischemic injury.
McElliott MC, Telang AC, Ference-Salo JT, Al-Suraimi A, Chowdhury M, Otto EA, Soofi A, Dressler GR, Beamish JA
American journal of physiology. Renal physiology 2025 Jan 1;328(1):F95-F106
American journal of physiology. Renal physiology 2025 Jan 1;328(1):F95-F106
Multi-strategy profiling identifies limonin's dual role in gout: restoring uric acid homeostasis and suppressing inflammatory response.
Zeng M, Zhong M, Zhong X, Zhang Y, Chen X, Lin J, Zhang Y, Zheng Y, Lu J, Huang M
Food & function 2025 Dec 8;16(24):9572-9592
Food & function 2025 Dec 8;16(24):9572-9592
Antihyperuricemic, hepatoprotective and nephroprotective roles of Benincasae Exocarpium in hyperuricemia rats.
Tong R, Ding B, Chen S, Yang W, Yi Y, He W, Zhou R, Wang Y, Li W, Qin S
Journal of ethnopharmacology 2025 Aug 29;352:120185
Journal of ethnopharmacology 2025 Aug 29;352:120185
Pediococcus acidilactici GR-5 alleviates hyperuricemia by degrading purine nucleosides and improving gut microbiota metabolism.
Ji J, An ZY, Khan A, Peng L, Kulshreshtha S, Salama ES, Yun H, Liu P, Jin WL, Li X
NPJ science of food 2025 Aug 23;9(1):183
NPJ science of food 2025 Aug 23;9(1):183
Chuanxiong Rhizoma extracts alleviate hyperuricaemia-induced renal injury by reducing serum UA levels and renoprotection.
Ma K, Zhou R, Yang HD, Pang XY, Li N, Song ZX, Tang ZS, Xu HB
Fitoterapia 2025 Apr;182:106456
Fitoterapia 2025 Apr;182:106456
Korean Red Ginseng Ameliorates the Level of Serum Uric Acid via Downregulating URAT1 and Upregulating OAT1 and OAT3.
Lee SY, Cho SS, Han KM, Lee MJ, Ahn T, Han B, Bae CS, Park DH
Biological & pharmaceutical bulletin 2024;47(11):1876-1882
Biological & pharmaceutical bulletin 2024;47(11):1876-1882
Lactiplantibacillus plantarum 06CC2 Enhanced the Expression of Intestinal Uric Acid Excretion Transporter in Mice.
Nei S, Matsusaki T, Kawakubo H, Ogawa K, Nishiyama K, Tsend-Ayush C, Nakano T, Takeshita M, Shinyama T, Yamasaki M
Nutrients 2024 Sep 9;16(17)
Nutrients 2024 Sep 9;16(17)
Sustained alterations in proximal tubule gene expression in primary culture associate with HNF4A loss.
Telang AC, Ference-Salo JT, McElliott MC, Chowdhury M, Beamish JA
Scientific reports 2024 Oct 2;14(1):22927
Scientific reports 2024 Oct 2;14(1):22927
Metabolic Communication by SGLT2 Inhibition.
Billing AM, Kim YC, Gullaksen S, Schrage B, Raabe J, Hutzfeldt A, Demir F, Kovalenko E, Lassé M, Dugourd A, Fallegger R, Klampe B, Jaegers J, Li Q, Kravtsova O, Crespo-Masip M, Palermo A, Fenton RA, Hoxha E, Blankenberg S, Kirchhof P, Huber TB, Laugesen E, Zeller T, Chrysopoulou M, Saez-Rodriguez J, Magnussen C, Eschenhagen T, Staruschenko A, Siuzdak G, Poulsen PL, Schwab C, Cuello F, Vallon V, Rinschen MM
Circulation 2024 Mar 12;149(11):860-884
Circulation 2024 Mar 12;149(11):860-884
Analyzing chemical composition of Sargentodoxae caulis water extract and their hypouricemia effect in hyperuricemic mice.
Liu WW, Dong HJ, Zhang Z, Ma XH, Liu S, Huang W, Wang X
Fitoterapia 2024 Jun;175:105926
Fitoterapia 2024 Jun;175:105926
Fuling-Zexie formula attenuates hyperuricemia-induced nephropathy and inhibits JAK2/STAT3 signaling and NLRP3 inflammasome activation in mice.
Lu M, Yin J, Xu T, Dai X, Liu T, Zhang Y, Wang S, Liu Y, Shi H, Zhang Y, Mo F, Sukhorukov V, Orekhov AN, Gao S, Wang L, Zhang D
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117262
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117262
Data mining-guided alleviation of hyperuricemia by Paeonia veitchii Lynch through inhibition of xanthine oxidase and regulation of renal urate transporters.
Du J, Wang N, Yu D, He P, Gao Y, Tu Y, Li Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155305
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155305
SGLT2 inhibitor dapagliflozin protects the kidney in a murine model of Balkan nephropathy.
Oe Y, Kim YC, Sidorenko VS, Zhang H, Kanoo S, Lopez N, Goodluck HA, Crespo-Masip M, Vallon V
American journal of physiology. Renal physiology 2024 Feb 1;326(2):F227-F240
American journal of physiology. Renal physiology 2024 Feb 1;326(2):F227-F240
The SGLT2 inhibitor dapagliflozin ameliorates renal fibrosis in hyperuricemic nephropathy.
Hu H, Li W, Hao Y, Peng Z, Zou Z, Wei J, Zhou Y, Liang W, Cao Y
Cell reports. Medicine 2024 Aug 20;5(8):101690
Cell reports. Medicine 2024 Aug 20;5(8):101690
Paeonia × suffruticosa Andrews leaf extract and its main component apigenin 7-O-glucoside ameliorate hyperuricemia by inhibiting xanthine oxidase activity and regulating renal urate transporters.
Zhang Y, Li Y, Li C, Zhao Y, Xu L, Ma S, Lin F, Xie Y, An J, Wang S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154957
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154957
Amelioration effects of α-viniferin on hyperuricemia and hyperuricemia-induced kidney injury in mice.
Guo XL, Gao YY, Yang YX, Zhu QF, Guan HY, He X, Zhang CL, Wang Y, Xu GB, Zou SH, Wei MC, Zhang J, Zhang JJ, Liao SG
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154868
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154868
Inhibition of Transforming Growth Factor-β Improves Primary Renal Tubule Cell Differentiation in Long-Term Culture.
Hunter K, Larsen JA, Love HD, Evans RC, Roy S, Zent R, Harris RC, Wilson MH, Fissell WH
Tissue engineering. Part A 2023 Feb;29(3-4):102-111
Tissue engineering. Part A 2023 Feb;29(3-4):102-111
Sanghuangporus vaninii ethanol extract alleviates hyperuricemic renal injury by regulating the uric acid transporters and inhibiting HK-2 apoptosis.
Hua L, Zhang S, Yang J, Zhou X, Shi S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114970
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114970
Simiao San alleviates hyperuricemia and kidney inflammation by inhibiting NLRP3 inflammasome and JAK2/STAT3 signaling in hyperuricemia mice.
Zhang Y, Wang S, Dai X, Liu T, Liu Y, Shi H, Yin J, Xu T, Zhang Y, Zhao D, Sukhorukov V, Orekhov AN, Gao S, Wang L, Zhang D
Journal of ethnopharmacology 2023 Aug 10;312:116530
Journal of ethnopharmacology 2023 Aug 10;312:116530
Therapeutic effects and mechanisms of N-(9,10-anthraquinone-2-ylcarbonyl) xanthine oxidase inhibitors on hyperuricemia.
Gao T, Xu J, Xiao Y, Li J, Hu W, Su X, Shen X, Yu W, Chen Z, Huang B, Li H, Wang X
Frontiers in pharmacology 2022;13:950699
Frontiers in pharmacology 2022;13:950699
Apigenin Ameliorates Hyperuricemia and Renal Injury through Regulation of Uric Acid Metabolism and JAK2/STAT3 Signaling Pathway.
Liu T, Gao H, Zhang Y, Wang S, Lu M, Dai X, Liu Y, Shi H, Xu T, Yin J, Gao S, Wang L, Zhang D
Pharmaceuticals (Basel, Switzerland) 2022 Nov 21;15(11)
Pharmaceuticals (Basel, Switzerland) 2022 Nov 21;15(11)
Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms.
Zhao X, Wang J, Tang L, Li P, Ru J, Bai Y
Bioengineered 2021 Dec;12(1):589-600
Bioengineered 2021 Dec;12(1):589-600
Berberrubine attenuates potassium oxonate- and hypoxanthine-induced hyperuricemia by regulating urate transporters and JAK2/STAT3 signaling pathway.
Lin G, Yu Q, Xu L, Huang Z, Mai L, Jiang L, Su Z, Xie J, Li Y, Liu Y, Lin Z, Chen J
European journal of pharmacology 2021 Dec 5;912:174592
European journal of pharmacology 2021 Dec 5;912:174592
Active components from Lagotis brachystachya maintain uric acid homeostasis by inhibiting renal TLR4-NLRP3 signaling in hyperuricemic mice.
Zhu JX, Yang HY, Hu WQ, Cheng J, Liu Y, Yi LT, Cheng HY
Inflammopharmacology 2021 Aug;29(4):1187-1200
Inflammopharmacology 2021 Aug;29(4):1187-1200
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