Antibody data
- Antibody Data
- Antigen structure
- References [9]
- Comments [0]
- Validations [0]
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- Product number
- MA3-812 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Anti-RXRB Monoclonal Antibody (MOK13-17)
- Antibody type
- Monoclonal
- Antigen
- Recombinant full-length protein
- Description
- MA3-813 detects cellular retinoic acid binding protein I (CRABPI) from human, mouse, monkey, feline, bovine, rabbit, rat, turtle and chicken tissues. This antibody does not react with chameleon, goldfish and frog. This antibody does not cross-react with cellular retinol binding protein (CRBP), performic acid oxidized CRBP, interphotoreceptor retinoid binding protein or retinol binding protein. MA3-813 has been successfully used in Western blot, immunohistochemistry and ELISA procedures. By Western blot, this antibody detects a 16 kDa protein representing CRABPI from rat retinal supernatant. Immunohistochemical staining of CRABPI in rat retina with MA3-813 results in its localization to amacrine somata and laminae in the inner plexiform layer. The MA3-813 antigen is oxidized CRABPI from bovine retina.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- MOK13-17
- Vial size
- 100 µg
- Concentration
- Lot Dependent
- Storage
- -20° C, Avoid Freeze/Thaw Cycles
Submitted references Nuclear hormone retinoid X receptor (RXR) negatively regulates the glucose-stimulated insulin secretion of pancreatic ß-cells.
G2/M arrest by 1,25-dihydroxyvitamin D3 in ovarian cancer cells mediated through the induction of GADD45 via an exonic enhancer.
Ligand-dependent degradation of retinoid X receptors does not require transcriptional activity or coactivator interactions.
Heterodimeric DNA binding by the vitamin D receptor and retinoid X receptors is enhanced by 1,25-dihydroxyvitamin D3 and inhibited by 9-cis-retinoic acid. Evidence for allosteric receptor interactions.
Dominant negative retinoid X receptor beta inhibits retinoic acid-responsive gene regulation in embryonal carcinoma cells.
Retinoid X receptors stimulate and 9-cis retinoic acid inhibits 1,25-dihydroxyvitamin D3-activated expression of the rat osteocalcin gene.
Inhibition of estrogen-responsive gene activation by the retinoid X receptor beta: evidence for multiple inhibitory pathways.
Heterodimerization of thyroid hormone (TH) receptor with H-2RIIBP (RXR beta) enhances DNA binding and TH-dependent transcriptional activation.
A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR.
Miyazaki S, Taniguchi H, Moritoh Y, Tashiro F, Yamamoto T, Yamato E, Ikegami H, Ozato K, Miyazaki J
Diabetes 2010 Nov;59(11):2854-61
Diabetes 2010 Nov;59(11):2854-61
G2/M arrest by 1,25-dihydroxyvitamin D3 in ovarian cancer cells mediated through the induction of GADD45 via an exonic enhancer.
Jiang F, Li P, Fornace AJ Jr, Nicosia SV, Bai W
The Journal of biological chemistry 2003 Nov 28;278(48):48030-40
The Journal of biological chemistry 2003 Nov 28;278(48):48030-40
Ligand-dependent degradation of retinoid X receptors does not require transcriptional activity or coactivator interactions.
Osburn DL, Shao G, Seidel HM, Schulman IG
Molecular and cellular biology 2001 Aug;21(15):4909-18
Molecular and cellular biology 2001 Aug;21(15):4909-18
Heterodimeric DNA binding by the vitamin D receptor and retinoid X receptors is enhanced by 1,25-dihydroxyvitamin D3 and inhibited by 9-cis-retinoic acid. Evidence for allosteric receptor interactions.
Thompson PD, Jurutka PW, Haussler CA, Whitfield GK, Haussler MR
The Journal of biological chemistry 1998 Apr 3;273(14):8483-91
The Journal of biological chemistry 1998 Apr 3;273(14):8483-91
Dominant negative retinoid X receptor beta inhibits retinoic acid-responsive gene regulation in embryonal carcinoma cells.
Minucci S, Zand DJ, Dey A, Marks MS, Nagata T, Grippo JF, Ozato K
Molecular and cellular biology 1994 Jan;14(1):360-72
Molecular and cellular biology 1994 Jan;14(1):360-72
Retinoid X receptors stimulate and 9-cis retinoic acid inhibits 1,25-dihydroxyvitamin D3-activated expression of the rat osteocalcin gene.
MacDonald PN, Dowd DR, Nakajima S, Galligan MA, Reeder MC, Haussler CA, Ozato K, Haussler MR
Molecular and cellular biology 1993 Sep;13(9):5907-17
Molecular and cellular biology 1993 Sep;13(9):5907-17
Inhibition of estrogen-responsive gene activation by the retinoid X receptor beta: evidence for multiple inhibitory pathways.
Segars JH, Marks MS, Hirschfeld S, Driggers PH, Martinez E, Grippo JF, Brown M, Wahli W, Ozato K
Molecular and cellular biology 1993 Apr;13(4):2258-68
Molecular and cellular biology 1993 Apr;13(4):2258-68
Heterodimerization of thyroid hormone (TH) receptor with H-2RIIBP (RXR beta) enhances DNA binding and TH-dependent transcriptional activation.
Hallenbeck PL, Marks MS, Lippoldt RE, Ozato K, Nikodem VM
Proceedings of the National Academy of Sciences of the United States of America 1992 Jun 15;89(12):5572-6
Proceedings of the National Academy of Sciences of the United States of America 1992 Jun 15;89(12):5572-6
A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR.
Mangelsdorf DJ, Umesono K, Kliewer SA, Borgmeyer U, Ong ES, Evans RM
Cell 1991 Aug 9;66(3):555-61
Cell 1991 Aug 9;66(3):555-61
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