12172-1-AP

antibody from Proteintech Group

Targeting: FKBP10 FKBP6, FKBP65, FLJ20683, FLJ22041, FLJ23833, hFKBP65

Provider product page for 12172-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [27]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 12172-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#12172-1-AP, RRID:AB_2102550
Product name: FKBP65 antibody
Antibody type: Polyclonal
Description: KD/KO validated FKBP65 antibody (Cat. #12172-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

FKBP10 protein structure - 12172-1-AP shown in red.

Submitted references Pan-cancer analysis identifies FKBP10 as a regulator of tumor immunosuppression and therapeutic response.

Li Y, Chen J, Li S, Tu G, Tang L
Translational oncology 2026 May;67:102749

FKBP10 as a prognostic biomarker and therapeutic target in hepatocellular carcinoma.

Xie X, Li J, Zhang AQ, Wu L, Wu C, Tang PM, Liu X
Discover oncology 2026 Feb 15;17(1)

FKBP10 Promotes the Muscle Invasion of Bladder Cancer via Lamin A Dysregulation.

Zhao X, Wang J, Tian S, Tang L, Cao S, Ye J, Cai T, Xuan Y, Zhang X, Li X, Li H
International journal of biological sciences 2025;21(2):758-771

Novel Biomarkers for Lymph Node Metastasis and Prognosis of Bladder Cancer by Bioinformatics Analysis.

Sun Y, Ding M, Sun J, Zhang Q, Cao W, Chen W, Wang X, Diao W, Guo H
ACS omega 2025 Oct 28;10(42):50124-50138

Integrated single-cell and bulk RNA sequencing analysis establishes a cancer associated fibroblast-related signature for predicting prognosis and therapeutic responses in neuroblastoma.

Cao Z, Wang Q, Han Y, Lin J, Wu Q, Xu C, Lv J, Zhang L, Gao H, Jiang D
Discover oncology 2025 Jul 1;16(1):1235

RDYH58 functional exosomes targeting myofibroblasts loaded with siFKBP10 for inhibition of collagen biosynthesis and secretion of IPF.

Yuan R, Mu Z, Zhang H, Tian Y, Xin Q, Tu Q, Zhang Y, Li Y, Zhang Z, Chu Y, Wang A, Tian J, Wang H, Qiu C, Shi Y
Acta pharmaceutica Sinica. B 2025 Dec;15(12):6681-6697

FKBP10 Silencing Alleviates Gluteal Muscle Contracture by Inhibiting Fibrosis and Restoring Autophagy via HSP47/SMAD3 Pathway Inactivation.

Xu H, Yao J, Jin Q, Yao J, Ren L, Zhu J, Luo W, Zheng P, Li L, Zhou J
The American journal of pathology 2025 Aug;195(8):1504-1522

Loss of the long form of Plod2 phenocopies contractures of Bruck syndrome-osteogenesis imperfecta.

Kot A, Chun C, Martin JH, Wachtell D, Hudson D, Weis M, Marks H, Srivastava S, Eyre DR, Duran I, Zieba J, Krakow D
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2024 Sep 2;39(9):1240-1252

Personalized drug screening using patient-derived organoid and its clinical relevance in gastric cancer.

Zhao Y, Li S, Zhu L, Huang M, Xie Y, Song X, Chen Z, Lau HC, Sung JJ, Xu L, Yu J, Li X
Cell reports. Medicine 2024 Jul 16;5(7):101627

Melanoma-intrinsic NR2F6 activity regulates antitumor immunity.

Kim H, Feng Y, Murad R, Pozniak J, Pelz C, Chen Y, Dalal B, Sears R, Sergienko E, Jackson M, Ruppin E, Herlyn M, Harris C, Marine JC, Klepsch V, Baier G, Ronai ZA
Science advances 2023 Jul 7;9(27):eadf6621

Clinical features and molecular characterization of Chinese patients with FKBP10 variants.

Tan Z, Shek HT, Chen P, Dong Z, Zhou Y, Yin S, Qiu A, Dong L, Gao B, To MKT
Molecular genetics & genomic medicine 2023 Apr;11(4):e2122

Lysyl hydroxylase 2 mediated collagen post-translational modifications and functional outcomes.

Terajima M, Taga Y, Nakamura T, Guo HF, Kayashima Y, Maeda-Smithies N, Parag-Sharma K, Kim JS, Amelio AL, Mizuno K, Kurie JM, Yamauchi M
Scientific reports 2022 Aug 22;12(1):14256

Silencing Heat Shock Protein 47 (HSP47) in Fibrogenic Precision-Cut Lung Slices: A Surprising Lack of Effects on Fibrogenesis?

Ruigrok MJR, El Amasi KEM, Leeming DJ, Sand JMB, Frijlink HW, Hinrichs WLJ, Olinga P
Frontiers in medicine 2021;8:607962

Localized chondro-ossification underlies joint dysfunction and motor deficits in the Fkbp10 mouse model of osteogenesis imperfecta.

Lim J, Lietman C, Grol MW, Castellon A, Dawson B, Adeyeye M, Rai J, Weis M, Keene DR, Schweitzer R, Park D, Eyre DR, Krakow D, Lee BH
Proceedings of the National Academy of Sciences of the United States of America 2021 Jun 22;118(25)

Identification of signal peptide features for substrate specificity in human Sec62/Sec63-dependent ER protein import.

Schorr S, Nguyen D, Haßdenteufel S, Nagaraj N, Cavalié A, Greiner M, Weissgerber P, Loi M, Paton AW, Paton JC, Molinari M, Förster F, Dudek J, Lang S, Helms V, Zimmermann R
The FEBS journal 2020 Nov;287(21):4612-4640

FKBP10 Regulates Protein Translation to Sustain Lung Cancer Growth.

Ramadori G, Ioris RM, Villanyi Z, Firnkes R, Panasenko OO, Allen G, Konstantinidou G, Aras E, Brenachot X, Biscotti T, Charollais A, Luchetti M, Bezrukov F, Santinelli A, Samad M, Baldi P, Collart MA, Coppari R
Cell reports 2020 Mar 17;30(11):3851-3863.e6

IFT20 is critical for collagen biosynthesis in craniofacial bone formation.

Yamaguchi H, Terajima M, Kitami M, Wang J, He L, Saeki M, Yamauchi M, Komatsu Y
Biochemical and biophysical research communications 2020 Dec 17;533(4):739-744

Cyclophilin B control of lysine post-translational modifications of skin type I collagen.

Terajima M, Taga Y, Cabral WA, Liu Y, Nagasawa M, Sumida N, Kayashima Y, Chandrasekaran P, Han L, Maeda N, Perdivara I, Hattori S, Marini JC, Yamauchi M
PLoS genetics 2019 Jun;15(6):e1008196

Heat shock protein 47 and 65-kDa FK506-binding protein weakly but synergistically interact during collagen folding in the endoplasmic reticulum.

Ishikawa Y, Holden P, Bächinger HP
The Journal of biological chemistry 2017 Oct 20;292(42):17216-17224

Fkbp10 Deletion in Osteoblasts Leads to Qualitative Defects in Bone.

Lietman CD, Lim J, Grafe I, Chen Y, Ding H, Bi X, Ambrose CG, Fratzl-Zelman N, Roschger P, Klaushofer K, Wagermaier W, Schmidt I, Fratzl P, Rai J, Weis M, Eyre D, Keene DR, Krakow D, Lee BH
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2017 Jun;32(6):1354-1367

A Chaperone Complex Formed by HSP47, FKBP65, and BiP Modulates Telopeptide Lysyl Hydroxylation of Type I Procollagen.

Duran I, Martin JH, Weis MA, Krejci P, Konik P, Li B, Alanay Y, Lietman C, Lee B, Eyre D, Cohn DH, Krakow D
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2017 Jun;32(6):1309-1319

FKBP65-dependent peptidyl-prolyl isomerase activity potentiates the lysyl hydroxylase 2-driven collagen cross-link switch.

Chen Y, Terajima M, Banerjee P, Guo H, Liu X, Yu J, Yamauchi M, Kurie JM
Scientific reports 2017 Apr 5;7:46021

Disentangling mechanisms involved in collagen pyridinoline cross-linking: The immunophilin FKBP65 is critical for dimerization of lysyl hydroxylase 2.

Gjaltema RA, van der Stoel MM, Boersema M, Bank RA
Proceedings of the National Academy of Sciences of the United States of America 2016 Jun 28;113(26):7142-7

HSP47 and FKBP65 cooperate in the synthesis of type I procollagen.

Duran I, Nevarez L, Sarukhanov A, Wu S, Lee K, Krejci P, Weis M, Eyre D, Krakow D, Cohn DH
Human molecular genetics 2015 Apr 1;24(7):1918-28

Connective tissue alterations in Fkbp10-/- mice.

Lietman CD, Rajagopal A, Homan EP, Munivez E, Jiang MM, Bertin TK, Chen Y, Hicks J, Weis M, Eyre D, Lee B, Krakow D
Human molecular genetics 2014 Sep 15;23(18):4822-31

Proteomic mapping of the human mitochondrial intermembrane space in live cells via ratiometric APEX tagging.

Hung V, Zou P, Rhee HW, Udeshi ND, Cracan V, Svinkina T, Carr SA, Mootha VK, Ting AY
Molecular cell 2014 Jul 17;55(2):332-41

Endoplasmic reticulum stress or mutation of an EF-hand Ca(2+)-binding domain directs the FKBP65 rotamase to an ERAD-based proteolysis.

Murphy LA, Ramirez EA, Trinh VT, Herman AM, Anderson VC, Brewster JL
Cell stress & chaperones 2011 Nov;16(6):607-19

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HEK-293 cells were subjected to SDS PAGE followed by western blot with 12172-1-AP( FKBP10 Antibody) at dilution of 1:600
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The FKBP10 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human FKBP10. This antibody recognizes human,mouse,rat antigen. The FKBP10 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
Appendix: 12172-1-AP.pdf

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