ACKR2

This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008]

Description

Atypical chemokine receptor 2

Tissue specificity

Tissue enhanced (liver, placenta)

Subcell location

Nucleoplasm, Vesicles, Cytosol

Predicted location

Membrane

Protein family

G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

3 (42804752 - 42887974)

Ensembl ID

ENSG00000144648  (ver. 103.38)

Orthologs

Mouse Ackr2: ENSMUSG00000044534

UniProt

O00590

neXtProt

NX_O00590

Human splice variants
Mouse splice variants

Protein structure