KATNB1

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases. [provided by RefSeq, Jul 2008]

Description

Katanin regulatory subunit B1

Tissue specificity

Low tissue specificity

Subcell location

Plasma membrane, Microtubules, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

16 (57735739 - 57757244)

Ensembl ID

ENSG00000140854  (ver. 103.38)

Orthologs

Mouse Katnb1: ENSMUSG00000031787

UniProt

Q9BVA0

neXtProt

NX_Q9BVA0

Human splice variants
Mouse splice variants

Protein structure