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- Antigen structure
- References [19]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 15617-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15617-1-AP, RRID:AB_2169527
- Product name
- PRC1 antibody
- Antibody type
- Polyclonal
- Description
- PRC1 antibody (Cat. #15617-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Identification of naphthalimide-derivatives as novel PBD-targeted polo-like kinase 1 inhibitors with efficacy in drug-resistant lung cancer cells.
MicroRNA-30c-5p arrests bladder cancer G2/M phase and suppresses its progression by targeting PRC1-mediated blocking of CDK1/Cyclin B1 axis.
An oocyte meiotic midbody cap is required for developmental competence in mice.
Spindle assembly checkpoint insensitivity allows meiosis-II despite chromosomal defects in aged eggs.
An oocyte meiotic midbody cap is required for developmental competence in mice.
PRC1 and RACGAP1 are Diagnostic Biomarkers of Early HCC and PRC1 Drives Self-Renewal of Liver Cancer Stem Cells.
The mechanism of acentrosomal spindle assembly in human oocytes.
The ciliopathy protein CCDC66 controls mitotic progression and cytokinesis by promoting microtubule nucleation and organization.
A noncoding regulatory RNA Gm31932 induces cell cycle arrest and differentiation in melanoma via the miR-344d-3-5p/Prc1 (and Nuf2) axis.
Identifying and Validating Potential Biomarkers of Early Stage Lung Adenocarcinoma Diagnosis and Prognosis.
Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer.
Aurora kinase B inhibits aurora kinase A to control maternal mRNA translation in mouse oocytes.
PRC1 is a critical regulator for anaphase spindle midzone assembly and cytokinesis in mouse oocyte meiosis.
Distinct classes of lagging chromosome underpin age-related oocyte aneuploidy in mouse.
Piperlongumine promotes death of retinoblastoma cancer cells.
Cdk1 negatively regulates the spindle localization of Prc1 in mouse oocytes.
Chromokinesin Kif4 promotes proper anaphase in mouse oocyte meiosis.
Biocompatible PEGylated Gold nanorods function As cytokinesis inhibitors to suppress angiogenesis.
Oocyte stage-specific effects of MTOR determine granulosa cell fate and oocyte quality in mice.
Li P, Li Y, Ma X, Li L, Zeng S, Peng Y, Liang H, Zhang G
European journal of medicinal chemistry 2024 May 5;271:116416
European journal of medicinal chemistry 2024 May 5;271:116416
MicroRNA-30c-5p arrests bladder cancer G2/M phase and suppresses its progression by targeting PRC1-mediated blocking of CDK1/Cyclin B1 axis.
Hao Y, Zhu Y, Sun F, Xu D, Wang C
Cellular signalling 2023 Oct;110:110836
Cellular signalling 2023 Oct;110:110836
An oocyte meiotic midbody cap is required for developmental competence in mice.
Schindler K, Jung GI, Londoño-Vásquez D, Park S, Skop A, Balboula A
Research square 2023 Oct 5;
Research square 2023 Oct 5;
Spindle assembly checkpoint insensitivity allows meiosis-II despite chromosomal defects in aged eggs.
Mihajlović AI, Byers C, Reinholdt L, FitzHarris G
EMBO reports 2023 Nov 6;24(11):e57227
EMBO reports 2023 Nov 6;24(11):e57227
An oocyte meiotic midbody cap is required for developmental competence in mice.
Jung GI, Londoño-Vásquez D, Park S, Skop AR, Balboula AZ, Schindler K
Nature communications 2023 Nov 16;14(1):7419
Nature communications 2023 Nov 16;14(1):7419
PRC1 and RACGAP1 are Diagnostic Biomarkers of Early HCC and PRC1 Drives Self-Renewal of Liver Cancer Stem Cells.
Liao S, Wang K, Zhang L, Shi G, Wang Z, Chen Z, Zhu P, He Q
Frontiers in cell and developmental biology 2022;10:864051
Frontiers in cell and developmental biology 2022;10:864051
The mechanism of acentrosomal spindle assembly in human oocytes.
Wu T, Dong J, Fu J, Kuang Y, Chen B, Gu H, Luo Y, Gu R, Zhang M, Li W, Dong X, Sun X, Sang Q, Wang L
Science (New York, N.Y.) 2022 Nov 18;378(6621):eabq7361
Science (New York, N.Y.) 2022 Nov 18;378(6621):eabq7361
The ciliopathy protein CCDC66 controls mitotic progression and cytokinesis by promoting microtubule nucleation and organization.
Batman U, Deretic J, Firat-Karalar EN
PLoS biology 2022 Jul;20(7):e3001708
PLoS biology 2022 Jul;20(7):e3001708
A noncoding regulatory RNA Gm31932 induces cell cycle arrest and differentiation in melanoma via the miR-344d-3-5p/Prc1 (and Nuf2) axis.
Wang D, Chen J, Li B, Jiang Q, Liu L, Xia Z, Zheng Q, Li M, Li D
Cell death & disease 2022 Apr 7;13(4):314
Cell death & disease 2022 Apr 7;13(4):314
Identifying and Validating Potential Biomarkers of Early Stage Lung Adenocarcinoma Diagnosis and Prognosis.
Chen Y, Jin L, Jiang Z, Liu S, Feng W
Frontiers in oncology 2021;11:644426
Frontiers in oncology 2021;11:644426
Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer.
Li J, Ohmura S, Marchetto A, Orth MF, Imle R, Dallmayer M, Musa J, Knott MML, Hölting TLB, Stein S, Funk CM, Sastre A, Alonso J, Bestvater F, Kasan M, Romero-Pérez L, Hartmann W, Ranft A, Banito A, Dirksen U, Kirchner T, Cidre-Aranaz F, Grünewald TGP
Nature communications 2021 Sep 16;12(1):5356
Nature communications 2021 Sep 16;12(1):5356
Aurora kinase B inhibits aurora kinase A to control maternal mRNA translation in mouse oocytes.
Aboelenain M, Schindler K
Development (Cambridge, England) 2021 Nov 1;148(21)
Development (Cambridge, England) 2021 Nov 1;148(21)
PRC1 is a critical regulator for anaphase spindle midzone assembly and cytokinesis in mouse oocyte meiosis.
Li XH, Ju JQ, Pan ZN, Wang HH, Wan X, Pan MH, Xu Y, Sun MH, Sun SC
The FEBS journal 2021 May;288(9):3055-3067
The FEBS journal 2021 May;288(9):3055-3067
Distinct classes of lagging chromosome underpin age-related oocyte aneuploidy in mouse.
Mihajlović AI, Haverfield J, FitzHarris G
Developmental cell 2021 Aug 23;56(16):2273-2283.e3
Developmental cell 2021 Aug 23;56(16):2273-2283.e3
Piperlongumine promotes death of retinoblastoma cancer cells.
Allaman-Pillet N, Schorderet DF
Oncotarget 2021 Apr 27;12(9):907-916
Oncotarget 2021 Apr 27;12(9):907-916
Cdk1 negatively regulates the spindle localization of Prc1 in mouse oocytes.
Nishiyama S, Yoshida S, Kitajima TS
Genes to cells : devoted to molecular & cellular mechanisms 2020 Oct;25(10):685-694
Genes to cells : devoted to molecular & cellular mechanisms 2020 Oct;25(10):685-694
Chromokinesin Kif4 promotes proper anaphase in mouse oocyte meiosis.
Heath CM, Wignall SM
Molecular biology of the cell 2019 Jul 1;30(14):1691-1704
Molecular biology of the cell 2019 Jul 1;30(14):1691-1704
Biocompatible PEGylated Gold nanorods function As cytokinesis inhibitors to suppress angiogenesis.
Song H, Guo T, Zhao Z, Wei Y, Luo H, Weng W, Zhang R, Zhong M, Chen C, Su J, Shen W
Biomaterials 2018 Sep;178:23-35
Biomaterials 2018 Sep;178:23-35
Oocyte stage-specific effects of MTOR determine granulosa cell fate and oocyte quality in mice.
Guo J, Zhang T, Guo Y, Sun T, Li H, Zhang X, Yin H, Cao G, Yin Y, Wang H, Shi L, Guo X, Sha J, Eppig JJ, Su YQ
Proceedings of the National Academy of Sciences of the United States of America 2018 Jun 5;115(23):E5326-E5333
Proceedings of the National Academy of Sciences of the United States of America 2018 Jun 5;115(23):E5326-E5333
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 15617-1-AP(PRC1 antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 15617-1-AP(PRC1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PRC1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PRC1. This antibody recognizes human, mouse, rat antigen. The PRC1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
