16921-1-AP

antibody from Proteintech Group

Targeting: ATL3 DKFZP564J0863

Provider product page for 16921-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [26]
Comments [0]
Validations
Western blot [2]
Immunocytochemistry [1]

Submit

Product number: 16921-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#16921-1-AP, RRID:AB_2290228
Product name: ATL3 antibody
Antibody type: Polyclonal
Description: KD/KO validated ATL3 antibody (Cat. #16921-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ATL3 protein structure - 16921-1-AP shown in red.

Submitted references A GluN2B disease-associated variant promotes the degradation of NMDA receptors via autophagy.

Benske TM, Williams MP, Zhang PP, Palumbo AJ, Mu TW
The Journal of biological chemistry 2026 Mar;302(3):111147

XIAP Stabilizes DDRGK1 to Promote ER-Phagy and Protects Against Noise-Induced Hearing Loss.

Yan L, Zhang Y, Du J, Zhu Y, Cao W, Wei Y, Wu H, Qiu S, Pan S, Chen L, Liang P, Chai R, Yang J, Fang Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(18):e11217

Membralin Assembles a MAN1B1-VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation.

Zhang J, Lu X, Li S, Wang T, Ahmad I, Zheng YH
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(9):e19256

Tubular ER structures shaped by ER-phagy receptors engage in stress-induced Golgi bypass.

Song MS, Sim HJ, Eun SH, Jung MK, Hwang SJ, Ham MH, Kwak K, Lee HJ, Kim JY, Jang DG, Chung HC, Shin DH, Kim YJ, Noh SH, Mun JY, Lee JM, Lee MG
Developmental cell 2025 Jun 9;60(11):1568-1585.e11

Membralin Selects Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation.

Zheng YH, Zhang J, Lu X, Li S, Wang T, Ahmad I
Research square 2025 Jun 23;

Two FAM134B isoforms differentially regulate ER dynamics during myogenesis.

Buonomo V, Lohachova K, Reggio A, Cano-Franco S, Cillo M, Santorelli L, Venditti R, Polishchuk E, Peluso I, Brunello L, Cirillo C, Petrosino S, Silva M, De Cegli R, Di Bartolomeo S, Gargioli C, Swuec P, Cortese M, Stolz A, Bhaskara RM, Grumati P
The EMBO journal 2025 Feb;44(4):1039-1073

Carvacrol alleviates endoplasmic reticulum stress and inflammation induced by lipopolysaccharide by enhancing endoplasmic reticulum autophagy in dairy mammary epithelial cells.

Yang Y, Li M, Wang J, Zhang H, Chang R, Zhao B, Aernouts B, Huang Q, Xu C
Journal of dairy science 2025 Dec;108(12):13919-13937

The impact of copper-induced oxidative damage on the endoplasmic reticulum quality control system in broiler kidneys.

Ma F, Wang M, Zhong G, Liao J, Huo Y, Wang Z, He S
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2025 Aug;38(4):1131-1143

The assembly of RAB22A/TMEM33/RTN4 initiates a secretory ER-phagy pathway.

Zheng X, Fang D, Shan H, Xiao B, Wei D, Ouyang Y, Huo L, Zhang Z, Wu Y, Zhang R, Kang T, Gao Y
Cell discovery 2025 Apr 29;11(1):41

A multi-subunit autophagic capture complex facilitates degradation of ER stalled MHC-I in pancreatic cancer.

Berquez M, Li AL, Luy MA, Venida AC, O'Loughlin T, Rademaker G, Barpanda A, Hu J, Yano J, Wiita A, Gilbert LA, Bruno PM, Perera RM
bioRxiv : the preprint server for biology 2024 Oct 29;

ER-phagy restrains inflammatory responses through its receptor UBAC2.

He X, He H, Hou Z, Wang Z, Shi Q, Zhou T, Wu Y, Qin Y, Wang J, Cai Z, Cui J, Jin S
The EMBO journal 2024 Nov;43(21):5057-5084

AMFR-mediated Flavivirus NS2A ubiquitination subverts ER-phagy to augment viral pathogenicity.

Zhang L, Wang H, Han C, Dong Q, Yan J, Guo W, Shan C, Zhao W, Chen P, Huang R, Wu Y, Chen Y, Qin Y, Chen M
Nature communications 2024 Nov 6;15(1):9578

Aurora kinase A-mediated phosphorylation triggers structural alteration of Rab1A to enhance ER complexity during mitosis.

Zhang W, Zhang Z, Xiang Y, Gu DD, Chen J, Chen Y, Zhai S, Liu Y, Jiang T, Liu C, He B, Yan M, Wang Z, Xu J, Cao YL, Deng B, Zeng D, Lei J, Zhuo J, Lei X, Long Z, Jin B, Chen T, Li D, Shen Y, Hu J, Gao S, Liu Q
Nature structural & molecular biology 2024 Feb;31(2):219-231

Fam134c and Fam134b shape axonal endoplasmic reticulum architecture in vivo.

Iavarone F, Zaninello M, Perrone M, Monaco M, Barth E, Gaedke F, Pizzo MT, Di Lorenzo G, Desiderio V, Sommella E, Merciai F, Salviati E, Campiglia P, Luongo L, De Leonibus E, Rugarli E, Settembre C
EMBO reports 2024 Aug;25(8):3651-3677

Pathological characteristics of axons and alterations of proteomic and lipidomic profiles in midbrain dopaminergic neurodegeneration induced by WDR45-deficiency.

Wang P, Shao Y, Al-Nusaif M, Zhang J, Yang H, Yang Y, Kim K, Li S, Liu C, Cai H, Le W
Molecular neurodegeneration 2024 Aug 26;19(1):62

Adaptive responses of neuronal cells to chronic endoplasmic reticulum (ER) stress.

Pham TNM, Perumal N, Manicam C, Basoglu M, Eimer S, Fuhrmann DC, Pietrzik CU, Clement AM, Körschgen H, Schepers J, Behl C
Redox biology 2023 Nov;67:102943

Deficiency of Perry syndrome-associated p150(Glued) in midbrain dopaminergic neurons leads to progressive neurodegeneration and endoplasmic reticulum abnormalities.

Yu J, Yang X, Zheng J, Sgobio C, Sun L, Cai H
NPJ Parkinson's disease 2023 Mar 7;9(1):35

Localization of Kif1c mRNA to cell protrusions dictates binding partner specificity of the encoded protein.

Norris ML, Mendell JT
Genes & development 2023 Mar 1;37(5-6):191-203

Heteromeric clusters of ubiquitinated ER-shaping proteins drive ER-phagy.

Foronda H, Fu Y, Covarrubias-Pinto A, Bocker HT, González A, Seemann E, Franzka P, Bock A, Bhaskara RM, Liebmann L, Hoffmann ME, Katona I, Koch N, Weis J, Kurth I, Gleeson JG, Reggiori F, Hummer G, Kessels MM, Qualmann B, Mari M, Dikić I, Hübner CA
Nature 2023 Jun;618(7964):402-410

The atlastin ER morphogenic proteins promote formation of a membrane penetration site during non-enveloped virus entry.

Pletan M, Liu X, Cha G, Chen YJ, Knupp J, Tsai B
Journal of virology 2023 Aug 31;97(8):e0075623

Profiling of purified autophagic vesicle degradome in the maturing and aging brain.

Kallergi E, Siva Sankar D, Matera A, Kolaxi A, Paolicelli RC, Dengjel J, Nikoletopoulou V
Neuron 2023 Aug 2;111(15):2329-2347.e7

ER proteins decipher the tubulin code to regulate organelle distribution.

Zheng P, Obara CJ, Szczesna E, Nixon-Abell J, Mahalingan KK, Roll-Mecak A, Lippincott-Schwartz J, Blackstone C
Nature 2022 Jan;601(7891):132-138

ATL3 Is a Tubular ER-Phagy Receptor for GABARAP-Mediated Selective Autophagy.

Chen Q, Xiao Y, Chai P, Zheng P, Teng J, Chen J
Current biology : CB 2019 Mar 4;29(5):846-855.e6

Influenza A virus ribonucleoproteins form liquid organelles at endoplasmic reticulum exit sites.

Alenquer M, Vale-Costa S, Etibor TA, Ferreira F, Sousa AL, Amorim MJ
Nature communications 2019 Apr 9;10(1):1629

DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling.

Zheng P, Chen Q, Tian X, Qian N, Chai P, Liu B, Hu J, Blackstone C, Zhu D, Teng J, Chen J
Cell research 2018 Aug;28(8):833-854

Efficient protein targeting to the inner nuclear membrane requires Atlastin-dependent maintenance of ER topology.

Pawar S, Ungricht R, Tiefenboeck P, Leroux JC, Kutay U
eLife 2017 Aug 14;6

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Jurkat cells were subjected to SDS PAGE followed by western blot with 16921-1-AP( ATL3 Antibody) at dilution of 1:1500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: SMMC-7721 cells were subjected to SDS PAGE followed by western blot with 16921-1-AP( ATL3 Antibody) at dilution of 1:600
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using ATL3 antibody 16921-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line