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- Antibody Data
- Antigen structure
- References [24]
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- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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- Product number
- 16251-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16251-1-AP, RRID:AB_2262469
- Product name
- FAF2 antibody
- Antibody type
- Polyclonal
- Description
- FAF2 antibody (Cat. #16251-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Localized K63 Ubiquitin Signaling Is Regulated by VCP/p97 During Oxidative Stress.
Neurotoxicity of Realgar: Crosstalk Between UBXD8-DRP1-Regulated Mitochondrial Fission and PINK1-Parkin-Mediated Mitophagy.
Targeting EGFR-binding protein SLC7A11 enhancing antitumor immunity of T cells via inducing MHC-I antigen presentation in nasopharyngeal carcinoma.
The p97-UBXD8 complex maintains peroxisome abundance by suppressing pexophagy.
The balance between antiviral and antibacterial responses during M. tuberculosis infection is regulated by the ubiquitin ligase CBL.
Localized K63 ubiquitin signaling is regulated by VCP/p97 during oxidative stress.
hnRNPA2B1 represses the disassembly of arsenite-induced stress granules and is essential for male fertility.
Cross-link assisted spatial proteomics to map sub-organelle proteomes and membrane protein topologies.
SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.
Featured interactome of homocysteine-inducible endoplasmic reticulum protein uncovers novel binding partners in response to ER stress.
Role of a holo-insertase complex in the biogenesis of biophysically diverse ER membrane proteins.
The p97-UBXD8 complex regulates ER-Mitochondria contact sites by altering membrane lipid saturation and composition.
The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.
UBXD8 mediates mitochondria-associated degradation to restrain apoptosis and mitophagy.
Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma.
Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner.
Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling.
A VCP inhibitor substrate trapping approach (VISTA) enables proteomic profiling of endogenous ERAD substrates.
The VCP-UBXN1 Complex Mediates Triage of Ubiquitylated Cytosolic Proteins Bound to the BAG6 Complex.
Lipid disequilibrium disrupts ER proteostasis by impairing ERAD substrate glycan trimming and dislocation.
gp78 functions downstream of Hrd1 to promote degradation of misfolded proteins of the endoplasmic reticulum.
USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation.
Characterization of the deubiquitinating activity of USP19 and its role in endoplasmic reticulum-associated degradation.
A ubiquitin-like domain recruits an oligomeric chaperone to a retrotranslocation complex in endoplasmic reticulum-associated degradation.
Maduka AO, Manohar S, Foster MW, Silva GM
Molecular & cellular proteomics : MCP 2025 Mar;24(3):100920
Molecular & cellular proteomics : MCP 2025 Mar;24(3):100920
Neurotoxicity of Realgar: Crosstalk Between UBXD8-DRP1-Regulated Mitochondrial Fission and PINK1-Parkin-Mediated Mitophagy.
Feng R, Liu J, Yao T, Yang Z, Jiang H
Molecular neurobiology 2025 Jun;62(6):7041-7053
Molecular neurobiology 2025 Jun;62(6):7041-7053
Targeting EGFR-binding protein SLC7A11 enhancing antitumor immunity of T cells via inducing MHC-I antigen presentation in nasopharyngeal carcinoma.
Wang H, Fan S, Zhan Y, Xu Y, Du Y, Luo J, Zang H, Peng S, Wang W
Cell death & disease 2025 Jan 16;16(1):21
Cell death & disease 2025 Jan 16;16(1):21
The p97-UBXD8 complex maintains peroxisome abundance by suppressing pexophagy.
Montes ID, Amirthagunanathan S, Joshi AS, Raman M
bioRxiv : the preprint server for biology 2024 Sep 26;
bioRxiv : the preprint server for biology 2024 Sep 26;
The balance between antiviral and antibacterial responses during M. tuberculosis infection is regulated by the ubiquitin ligase CBL.
Truong T, Martin K, Salemi M, Ray A, Phinney BS, Penn BH
bioRxiv : the preprint server for biology 2024 May 23;
bioRxiv : the preprint server for biology 2024 May 23;
Localized K63 ubiquitin signaling is regulated by VCP/p97 during oxidative stress.
Maduka AO, Manohar S, Foster MW, Silva GM
bioRxiv : the preprint server for biology 2024 Jun 21;
bioRxiv : the preprint server for biology 2024 Jun 21;
hnRNPA2B1 represses the disassembly of arsenite-induced stress granules and is essential for male fertility.
Wang X, Fan X, Zhang J, Wang F, Chen J, Wen Y, Wang L, Li T, Li H, Gu H, Zhang Y, Yuan S
Cell reports 2024 Feb 27;43(2):113769
Cell reports 2024 Feb 27;43(2):113769
Cross-link assisted spatial proteomics to map sub-organelle proteomes and membrane protein topologies.
Zhu Y, Akkaya KC, Ruta J, Yokoyama N, Wang C, Ruwolt M, Lima DB, Lehmann M, Liu F
Nature communications 2024 Apr 17;15(1):3290
Nature communications 2024 Apr 17;15(1):3290
SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.
Wang F, Wang L, Gan S, Feng S, Ouyang S, Wang X, Yuan S
Research (Washington, D.C.) 2023;6:0091
Research (Washington, D.C.) 2023;6:0091
Featured interactome of homocysteine-inducible endoplasmic reticulum protein uncovers novel binding partners in response to ER stress.
Su R, Yin J, Ruan X, Chen Y, Wan P, Luo Z
Computational and structural biotechnology journal 2023;21:4478-4487
Computational and structural biotechnology journal 2023;21:4478-4487
Role of a holo-insertase complex in the biogenesis of biophysically diverse ER membrane proteins.
Page KR, Nguyen VN, Pleiner T, Tomaleri GP, Wang ML, Guna A, Wang TY, Chou TF, Voorhees RM
bioRxiv : the preprint server for biology 2023 Nov 29;
bioRxiv : the preprint server for biology 2023 Nov 29;
The p97-UBXD8 complex regulates ER-Mitochondria contact sites by altering membrane lipid saturation and composition.
Ganji R, Paulo JA, Xi Y, Kline I, Zhu J, Clemen CS, Weihl CC, Purdy JG, Gygi SP, Raman M
Nature communications 2023 Feb 6;14(1):638
Nature communications 2023 Feb 6;14(1):638
The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.
Jaffray EG, Tatham MH, Mojsa B, Liczmanska M, Rojas-Fernandez A, Yin Y, Ball G, Hay RT
The Journal of cell biology 2023 Apr 3;222(4)
The Journal of cell biology 2023 Apr 3;222(4)
UBXD8 mediates mitochondria-associated degradation to restrain apoptosis and mitophagy.
Zheng J, Cao Y, Yang J, Jiang H
EMBO reports 2022 Oct 6;23(10):e54859
EMBO reports 2022 Oct 6;23(10):e54859
Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma.
Liu F, Tian T, Zhang Z, Xie S, Yang J, Zhu L, Wang W, Shi C, Sang L, Guo K, Yang Z, Qu L, Liu X, Liu J, Yan Q, Ju HQ, Wang W, Piao HL, Shao J, Zhou T, Lin A
Nature metabolism 2022 Aug;4(8):1022-1040
Nature metabolism 2022 Aug;4(8):1022-1040
Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner.
Gwon Y, Maxwell BA, Kolaitis RM, Zhang P, Kim HJ, Taylor JP
Science (New York, N.Y.) 2021 Jun 25;372(6549):eabf6548
Science (New York, N.Y.) 2021 Jun 25;372(6549):eabf6548
Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling.
Fenech EJ, Lari F, Charles PD, Fischer R, Laétitia-Thézénas M, Bagola K, Paton AW, Paton JC, Gyrd-Hansen M, Kessler BM, Christianson JC
eLife 2020 Jul 2;9
eLife 2020 Jul 2;9
A VCP inhibitor substrate trapping approach (VISTA) enables proteomic profiling of endogenous ERAD substrates.
Huang EY, To M, Tran E, Dionisio LTA, Cho HJ, Baney KLM, Pataki CI, Olzmann JA
Molecular biology of the cell 2018 May 1;29(9):1021-1030
Molecular biology of the cell 2018 May 1;29(9):1021-1030
The VCP-UBXN1 Complex Mediates Triage of Ubiquitylated Cytosolic Proteins Bound to the BAG6 Complex.
Ganji R, Mukkavalli S, Somanji F, Raman M
Molecular and cellular biology 2018 Jul 1;38(13)
Molecular and cellular biology 2018 Jul 1;38(13)
Lipid disequilibrium disrupts ER proteostasis by impairing ERAD substrate glycan trimming and dislocation.
To M, Peterson CW, Roberts MA, Counihan JL, Wu TT, Forster MS, Nomura DK, Olzmann JA
Molecular biology of the cell 2017 Jan 15;28(2):270-284
Molecular biology of the cell 2017 Jan 15;28(2):270-284
gp78 functions downstream of Hrd1 to promote degradation of misfolded proteins of the endoplasmic reticulum.
Zhang T, Xu Y, Liu Y, Ye Y
Molecular biology of the cell 2015 Dec 1;26(24):4438-50
Molecular biology of the cell 2015 Dec 1;26(24):4438-50
USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation.
Liu Y, Soetandyo N, Lee JG, Liu L, Xu Y, Clemons WM Jr, Ye Y
eLife 2014;3:e01369
eLife 2014;3:e01369
Characterization of the deubiquitinating activity of USP19 and its role in endoplasmic reticulum-associated degradation.
Lee JG, Kim W, Gygi S, Ye Y
The Journal of biological chemistry 2014 Feb 7;289(6):3510-7
The Journal of biological chemistry 2014 Feb 7;289(6):3510-7
A ubiquitin-like domain recruits an oligomeric chaperone to a retrotranslocation complex in endoplasmic reticulum-associated degradation.
Xu Y, Liu Y, Lee JG, Ye Y
The Journal of biological chemistry 2013 Jun 21;288(25):18068-76
The Journal of biological chemistry 2013 Jun 21;288(25):18068-76
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 16251-1-AP(FAF2 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-FAF2 (IP:16251-1-AP, 3ug; Detection:16251-1-AP 1:1000) with mouse brain tissue lysate 5000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The FAF2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human FAF2. This antibody recognizes human,mouse,rat antigen. The FAF2 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
