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Learn60075-1-Ig
antibody from Proteintech Group
Targeting: SEPTIN2
DIFF6, hNedd5, KIAA0158, NEDD5, Pnutl3, SEPT2
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [15]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 60075-1-Ig - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#60075-1-Ig, RRID:AB_2187016
- Product name
- Septin 2 antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated Septin 2 antibody (Cat. #60075-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 2F3B2
- Vial size
- 20ul, 150ul
Submitted references Septin-dependent defense mechanisms against Pseudomonas aeruginosa are stalled in cystic fibrosis bronchial epithelial cells.
The Septin Cytoskeleton is Required for Plasma Membrane Repair.
Splenectomy improves erythrocyte functionality in spherocytosis based on septin abundance, but not maturation defects.
Proteomic Analysis of Huntington's Disease Medium Spiny Neurons Identifies Alterations in Lipid Droplets.
Orai1 is an Entotic Ca(2+) Channel for Non-Apoptotic Cell Death, Entosis in Cancer Development.
Human septins organize as octamer-based filaments and mediate actin-membrane anchoring in cells.
Septins promote caspase activity and coordinate mitochondrial apoptosis.
Contribution of septins to human platelet structure and function.
Regulators of tubulin polyglutamylation control nuclear shape and cilium disassembly by balancing microtubule and actin assembly.
Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors.
A requirement for septins and the autophagy receptor p62 in the proliferation of intracellular Shigella.
Septins suppress the release of vaccinia virus from infected cells.
Cdc42 regulates Cdc42EP3 function in cancer-associated fibroblasts.
Cdc42EP3/BORG2 and Septin Network Enables Mechano-transduction and the Emergence of Cancer-Associated Fibroblasts.
A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.
Brax S, Gaudin C, Calmel C, Boëlle PY, Corvol H, Ruffin M, Guillot L
European journal of cell biology 2024 Jun;103(2):151416
European journal of cell biology 2024 Jun;103(2):151416
The Septin Cytoskeleton is Required for Plasma Membrane Repair.
Prislusky MI, Lam JG, Contreras VR, Ng M, Chamberlain M, Pathak-Sharma S, Fields M, Zhang X, Amer AO, Seveau S
bioRxiv : the preprint server for biology 2024 Jan 6;
bioRxiv : the preprint server for biology 2024 Jan 6;
Splenectomy improves erythrocyte functionality in spherocytosis based on septin abundance, but not maturation defects.
Cloos AS, Pollet H, Stommen A, Maja M, Lingurski M, Brichard B, Lambert C, Henriet P, Pierreux C, Pyr Dit Ruys S, Van Der Smissen P, Vikkula M, Gatto L, Martin M, Brouillard P, Vertommen D, Tyteca D
Blood advances 2023 Sep 12;7(17):4705-4720
Blood advances 2023 Sep 12;7(17):4705-4720
Proteomic Analysis of Huntington's Disease Medium Spiny Neurons Identifies Alterations in Lipid Droplets.
Tshilenge KT, Aguirre CG, Bons J, Gerencser AA, Basisty N, Song S, Rose J, Lopez-Ramirez A, Naphade S, Loureiro A, Battistoni E, Milani M, Wehrfritz C, Holtz A, Hetz C, Mooney SD, Schilling B, Ellerby LM
Molecular & cellular proteomics : MCP 2023 May;22(5):100534
Molecular & cellular proteomics : MCP 2023 May;22(5):100534
Orai1 is an Entotic Ca(2+) Channel for Non-Apoptotic Cell Death, Entosis in Cancer Development.
Lee AR, Park CY
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 May;10(14):e2205913
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 May;10(14):e2205913
Human septins organize as octamer-based filaments and mediate actin-membrane anchoring in cells.
Martins CS, Taveneau C, Castro-Linares G, Baibakov M, Buzhinsky N, Eroles M, Milanović V, Omi S, Pedelacq JD, Iv F, Bouillard L, Llewellyn A, Gomes M, Belhabib M, Kuzmić M, Verdier-Pinard P, Lee S, Badache A, Kumar S, Chandre C, Brasselet S, Rico F, Rossier O, Koenderink GH, Wenger J, Cabantous S, Mavrakis M
The Journal of cell biology 2023 Mar 6;222(3)
The Journal of cell biology 2023 Mar 6;222(3)
Septins promote caspase activity and coordinate mitochondrial apoptosis.
Van Ngo H, Robertin S, Brokatzky D, Bielecka MK, Lobato-Márquez D, Torraca V, Mostowy S
Cytoskeleton (Hoboken, N.J.) 2023 Jul-Aug;80(7-8):254-265
Cytoskeleton (Hoboken, N.J.) 2023 Jul-Aug;80(7-8):254-265
Contribution of septins to human platelet structure and function.
Kim OV, Litvinov RI, Mordakhanova ER, Bi E, Vagin O, Weisel JW
iScience 2022 Jul 15;25(7):104654
iScience 2022 Jul 15;25(7):104654
Regulators of tubulin polyglutamylation control nuclear shape and cilium disassembly by balancing microtubule and actin assembly.
Wang L, Paudyal SC, Kang Y, Owa M, Liang FX, Spektor A, Knaut H, Sánchez I, Dynlacht BD
Cell research 2022 Feb;32(2):190-209
Cell research 2022 Feb;32(2):190-209
Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors.
Li H, Saucedo-Cuevas L, Yuan L, Ross D, Johansen A, Sands D, Stanley V, Guemez-Gamboa A, Gregor A, Evans T, Chen S, Tan L, Molina H, Sheets N, Shiryaev SA, Terskikh AV, Gladfelter AS, Shresta S, Xu Z, Gleeson JG
Neuron 2019 Mar 20;101(6):1089-1098.e4
Neuron 2019 Mar 20;101(6):1089-1098.e4
A requirement for septins and the autophagy receptor p62 in the proliferation of intracellular Shigella.
Lobato-Márquez D, Krokowski S, Sirianni A, Larrouy-Maumus G, Mostowy S
Cytoskeleton (Hoboken, N.J.) 2019 Jan;76(1):163-172
Cytoskeleton (Hoboken, N.J.) 2019 Jan;76(1):163-172
Septins suppress the release of vaccinia virus from infected cells.
Pfanzelter J, Mostowy S, Way M
The Journal of cell biology 2018 Aug 6;217(8):2911-2929
The Journal of cell biology 2018 Aug 6;217(8):2911-2929
Cdc42 regulates Cdc42EP3 function in cancer-associated fibroblasts.
Farrugia AJ, Calvo F
Small GTPases 2017 Jan 2;8(1):49-57
Small GTPases 2017 Jan 2;8(1):49-57
Cdc42EP3/BORG2 and Septin Network Enables Mechano-transduction and the Emergence of Cancer-Associated Fibroblasts.
Calvo F, Ranftl R, Hooper S, Farrugia AJ, Moeendarbary E, Bruckbauer A, Batista F, Charras G, Sahai E
Cell reports 2015 Dec 29;13(12):2699-714
Cell reports 2015 Dec 29;13(12):2699-714
A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.
Garcia-Gonzalo FR, Corbit KC, Sirerol-Piquer MS, Ramaswami G, Otto EA, Noriega TR, Seol AD, Robinson JF, Bennett CL, Josifova DJ, García-Verdugo JM, Katsanis N, Hildebrandt F, Reiter JF
Nature genetics 2011 Jul 3;43(8):776-84
Nature genetics 2011 Jul 3;43(8):776-84
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 60075-1-Ig(SEPT2 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 60075-1-Ig(SEPT2 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 60075-1-Ig(SEPT2 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
