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- References [79]
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- Product number
- 14276-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14276-1-AP, RRID:AB_10888627
- Product name
- CNOT1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CNOT1 antibody (Cat. #14276-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Dissecting the Role of the Ccr4-Not Deadenylase Complex in Pluripotency and Differentiation.
XIST and MUC1-C form an auto-regulatory pathway in driving cancer progression.
DDX6 modulates P-body and stress granule assembly, composition, and docking.
Decline in corepressor CNOT1 in the pregnant myometrium near term impairs progesterone receptor function and increases contractile gene expression.
Regulation by the RNA-binding protein Unkempt at its effector interface.
Specific recognition and ubiquitination of translating ribosomes by mammalian CCR4-NOT.
RNA helicase DDX6 and scaffold protein GW182 in P-bodies promote biogenesis of stress granules.
Dystonia Linked to EIF4A2 Haploinsufficiency: A Disorder of Protein Translation Dysfunction.
A paradigm for regulation at the effector interface with RNA-binding proteins.
Cnot3 is required for male germ cell development and spermatogonial stem cell maintenance.
Pan-cancer tRNA-derived fragment CAT1 coordinates RBPMS to stabilize NOTCH2 mRNA to promote tumorigenesis.
SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers.
Retrotransposon LINE-1 bodies in the cytoplasm of piRNA-deficient mouse spermatocytes: Ribonucleoproteins overcoming the integrated stress response.
An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation.
Mechanism of ribosome-associated mRNA degradation during tubulin autoregulation.
Genome-wide CRISPR-Cas9 screen analyzed by SLIDER identifies network of repressor complexes that regulate TRIM24.
Disruption of the Mammalian Ccr4-Not Complex Contributes to Transcription-Mediated Genome Instability.
Ribonucleoprotein condensation driven by retrotransposon LINE-1 sustains RNA integrity and translation in mouse spermatocytes.
A program of successive gene expression in mouse one-cell embryos.
CCR4-NOT differentially controls host versus virus poly(a)-tail length and regulates HCMV infection.
Species-specific FMRP regulation of RACK1 is critical for prenatal cortical development.
Alphaherpesvirus-mediated remodeling of the cellular transcriptome results in depletion of m6A-containing transcripts.
Regulation of CCR4-NOT complex deadenylase activity and cellular responses by MK2-dependent phosphorylation of CNOT2.
Post-translational control of beige fat biogenesis by PRDM16 stabilization.
The Conserved CNOT1 Interaction Motif of Tristetraprolin Regulates ARE-mRNA Decay Independently of the p38 MAPK-MK2 Kinase Pathway.
Control of immediate early gene expression by CPEB4-repressor complex-mediated mRNA degradation.
UPF1 promotes rapid degradation of m(6)A-containing RNAs.
LC3B is an RNA-binding protein to trigger rapid mRNA degradation during autophagy.
RNF219 regulates CCR4-NOT function in mRNA translation and deadenylation.
TASOR epigenetic repressor cooperates with a CNOT1 RNA degradation pathway to repress HIV.
Tex13a Optimizes Sperm Motility via Its Potential Roles in mRNA Turnover.
The functional characterization of phosphorylation of tristetraprolin at C-terminal NOT1-binding domain.
Identification of Phosphorylated Amino Acids in Human TNRC6A C-Terminal Region and Their Effects on the Interaction with the CCR4-NOT Complex.
RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation.
YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways.
Multivalent Proteins Rapidly and Reversibly Phase-Separate upon Osmotic Cell Volume Change.
RNF219 interacts with CCR4-NOT in regulating stem cell differentiation.
Context-dependent functional compensation between Ythdf m(6)A reader proteins.
Systematic Analysis of Targets of Pumilio-Mediated mRNA Decay Reveals that PUM1 Repression by DNA Damage Activates Translesion Synthesis.
Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability.
Regulation of Fetal Genes by Transitions among RNA-Binding Proteins during Liver Development.
CSDE1 controls gene expression through the miRNA-mediated decay machinery.
UPF1/SMG7-dependent microRNA-mediated gene regulation.
A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation.
Dynamic Recruitment of Single RNAs to Processing Bodies Depends on RNA Functionality.
Endoribonucleolytic Cleavage of m(6)A-Containing RNAs by RNase P/MRP Complex.
Degradation of a Novel DNA Damage Response Protein, Tankyrase 1 Binding Protein 1, following Adenovirus Infection.
Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA.
Translational control of ERK signaling through miRNA/4EHP-directed silencing.
IMP2 and IMP3 cooperate to promote the metastasis of triple-negative breast cancer through destabilization of progesterone receptor.
Human MARF1 is an endoribonuclease that interacts with the DCP1:2 decapping complex and degrades target mRNAs.
CNOT1 is involved in TTP‑mediated ICAM‑1 and IL‑8 mRNA decay.
Comprehensive Identification of Nuclear and Cytoplasmic TNRC6A-Associating Proteins.
Cap-binding protein 4EHP effects translation silencing by microRNAs.
DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs.
The Mammalian Ribo-interactome Reveals Ribosome Functional Diversity and Heterogeneity.
Transcriptional Regulator CNOT3 Defines an Aggressive Colorectal Cancer Subtype.
Alternative splicing of CNOT7 diversifies CCR4-NOT functions.
Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription.
CNOT1 cooperates with LMNA to aggravate osteosarcoma tumorigenesis through the Hedgehog signaling pathway.
CNOT3-Dependent mRNA Deadenylation Safeguards the Pluripotent State.
A widespread sequence-specific mRNA decay pathway mediated by hnRNPs A1 and A2/B1.
Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements.
Codon Usage and 3' UTR Length Determine Maternal mRNA Stability in Zebrafish.
Post-transcriptional Control of Tumor Cell Autonomous Metastatic Potential by CCR4-NOT Deadenylase CNOT7.
The cAMP pathway regulates mRNA decay through phosphorylation of the RNA-binding protein TIS11b/BRF1.
YTHDF2 destabilizes m(6)A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complex.
CNOT3 suppression promotes necroptosis by stabilizing mRNAs for cell death-inducing proteins.
A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.
The eIF4E-Binding Protein 4E-T Is a Component of the mRNA Decay Machinery that Bridges the 5' and 3' Termini of Target mRNAs.
ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway.
Identification of Ccr4-not complex components as regulators of transition from partial to genuine induced pluripotent stem cells.
CNOT7/hCAF1 is involved in ICAM-1 and IL-8 regulation by tristetraprolin.
Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis.
Structural and biochemical insights to the role of the CCR4-NOT complex and DDX6 ATPase in microRNA repression.
Roquin promotes constitutive mRNA decay via a conserved class of stem-loop recognition motifs.
Trypanosome CNOT10 is essential for the integrity of the NOT deadenylase complex and for degradation of many mRNAs.
The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex.
Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation.
Wang X, Chen Q, Lackford B, Hu G
Methods in molecular biology (Clifton, N.J.) 2024;2723:125-141
Methods in molecular biology (Clifton, N.J.) 2024;2723:125-141
XIST and MUC1-C form an auto-regulatory pathway in driving cancer progression.
Wang K, Bhattacharya A, Haratake N, Daimon T, Nakashoji A, Ozawa H, Peng B, Li W, Kufe D
Cell death & disease 2024 May 13;15(5):330
Cell death & disease 2024 May 13;15(5):330
DDX6 modulates P-body and stress granule assembly, composition, and docking.
Ripin N, Macedo de Vasconcelos L, Ugay DA, Parker R
The Journal of cell biology 2024 Jun 3;223(6)
The Journal of cell biology 2024 Jun 3;223(6)
Decline in corepressor CNOT1 in the pregnant myometrium near term impairs progesterone receptor function and increases contractile gene expression.
Kwak YT, Montalbano AP, Kelleher AM, Colon-Caraballo M, Kraus WL, Mahendroo M, Mendelson CR
The Journal of biological chemistry 2024 Jul;300(7):107484
The Journal of biological chemistry 2024 Jul;300(7):107484
Regulation by the RNA-binding protein Unkempt at its effector interface.
Shah K, He S, Turner DJ, Corbo J, Rebbani K, Dominguez D, Bateman JM, Cheloufi S, Igreja C, Valkov E, Murn J
Nature communications 2024 Apr 11;15(1):3159
Nature communications 2024 Apr 11;15(1):3159
Specific recognition and ubiquitination of translating ribosomes by mammalian CCR4-NOT.
Absmeier E, Chandrasekaran V, O'Reilly FJ, Stowell JAW, Rappsilber J, Passmore LA
Nature structural & molecular biology 2023 Sep;30(9):1314-1322
Nature structural & molecular biology 2023 Sep;30(9):1314-1322
RNA helicase DDX6 and scaffold protein GW182 in P-bodies promote biogenesis of stress granules.
Majerciak V, Zhou T, Kruhlak MJ, Zheng ZM
Nucleic acids research 2023 Sep 22;51(17):9337-9355
Nucleic acids research 2023 Sep 22;51(17):9337-9355
Dystonia Linked to EIF4A2 Haploinsufficiency: A Disorder of Protein Translation Dysfunction.
Harrer P, Škorvánek M, Kittke V, Dzinovic I, Borngräber F, Thomsen M, Mandel V, Svorenova T, Ostrozovicova M, Kulcsarova K, Berutti R, Busch H, Ott F, Kopajtich R, Prokisch H, Kumar KR, Mencacci NE, Kurian MA, Di Fonzo A, Boesch S, Kühn AA, Blümlein U, Lohmann K, Haslinger B, Weise D, Jech R, Winkelmann J, Zech M
Movement disorders : official journal of the Movement Disorder Society 2023 Oct;38(10):1914-1924
Movement disorders : official journal of the Movement Disorder Society 2023 Oct;38(10):1914-1924
A paradigm for regulation at the effector interface with RNA-binding proteins.
Shah K, He S, Turner DJ, Corbo J, Rebbani K, Bateman JM, Cheloufi S, Igreja C, Valkov E, Murn J
bioRxiv : the preprint server for biology 2023 Oct 24;
bioRxiv : the preprint server for biology 2023 Oct 24;
Cnot3 is required for male germ cell development and spermatogonial stem cell maintenance.
Chen Q, Malki S, Xu X, Bennett B, Lackford BL, Kirsanov O, Geyer CB, Hu G
bioRxiv : the preprint server for biology 2023 Oct 14;
bioRxiv : the preprint server for biology 2023 Oct 14;
Pan-cancer tRNA-derived fragment CAT1 coordinates RBPMS to stabilize NOTCH2 mRNA to promote tumorigenesis.
Yu M, Yi J, Qiu Q, Yao D, Li J, Yang J, Mi C, Zhou L, Lu B, Lu W, Ying K, Chen W, Chen E, Zhang H, Lu Z, Lu Y, Liu P
Cell reports 2023 Nov 28;42(11):113408
Cell reports 2023 Nov 28;42(11):113408
SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers.
Shi L, Shen W, Davis MI, Kong K, Vu P, Saha SK, Adil R, Kreuzer J, Egan R, Lee TD, Greninger P, Shrimp JH, Zhao W, Wei TY, Zhou M, Eccleston J, Sussman J, Manocha U, Weerasekara V, Kondo H, Vijay V, Wu MJ, Kearney SE, Ho J, McClanaghan J, Murchie E, Crowther GS, Patnaik S, Boxer MB, Shen M, Ting DT, Kim WY, Stanger BZ, Deshpande V, Ferrone CR, Benes CH, Haas W, Hall MD, Bardeesy N
Nature cancer 2023 Mar;4(3):365-381
Nature cancer 2023 Mar;4(3):365-381
Retrotransposon LINE-1 bodies in the cytoplasm of piRNA-deficient mouse spermatocytes: Ribonucleoproteins overcoming the integrated stress response.
De Luca C, Gupta A, Bortvin A
PLoS genetics 2023 Jun;19(6):e1010797
PLoS genetics 2023 Jun;19(6):e1010797
An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation.
Yiu SPT, Zerbe C, Vanderwall D, Huttlin EL, Weekes MP, Gewurz BE
Molecular cell 2023 Jul 6;83(13):2367-2386.e15
Molecular cell 2023 Jul 6;83(13):2367-2386.e15
Mechanism of ribosome-associated mRNA degradation during tubulin autoregulation.
Höpfler M, Absmeier E, Peak-Chew SY, Vartholomaiou E, Passmore LA, Gasic I, Hegde RS
Molecular cell 2023 Jul 6;83(13):2290-2302.e13
Molecular cell 2023 Jul 6;83(13):2290-2302.e13
Genome-wide CRISPR-Cas9 screen analyzed by SLIDER identifies network of repressor complexes that regulate TRIM24.
Patel LR, Stratton SA, McLaughlin M, Krause P, Allton K, Rivas AL, Barbosa D, Hart T, Barton MC
iScience 2023 Jul 21;26(7):107126
iScience 2023 Jul 21;26(7):107126
Disruption of the Mammalian Ccr4-Not Complex Contributes to Transcription-Mediated Genome Instability.
Hagkarim NC, Hajkarim MC, Suzuki T, Fujiwara T, Winkler GS, Stewart GS, Grand RJ
Cells 2023 Jul 17;12(14)
Cells 2023 Jul 17;12(14)
Ribonucleoprotein condensation driven by retrotransposon LINE-1 sustains RNA integrity and translation in mouse spermatocytes.
Luca C, Gupta A, Bortvin A
bioRxiv : the preprint server for biology 2023 Jan 13;
bioRxiv : the preprint server for biology 2023 Jan 13;
A program of successive gene expression in mouse one-cell embryos.
Asami M, Lam BYH, Hoffmann M, Suzuki T, Lu X, Yoshida N, Ma MK, Rainbow K, Gužvić M, VerMilyea MD, Yeo GSH, Klein CA, Perry ACF
Cell reports 2023 Feb 28;42(2):112023
Cell reports 2023 Feb 28;42(2):112023
CCR4-NOT differentially controls host versus virus poly(a)-tail length and regulates HCMV infection.
Burgess HM, Grande R, Riccio S, Dinesh I, Winkler GS, Depledge DP, Mohr I
EMBO reports 2023 Dec 6;24(12):e56327
EMBO reports 2023 Dec 6;24(12):e56327
Species-specific FMRP regulation of RACK1 is critical for prenatal cortical development.
Shen M, Sirois CL, Guo Y, Li M, Dong Q, Méndez-Albelo NM, Gao Y, Khullar S, Kissel L, Sandoval SO, Wolkoff NE, Huang SX, Xu Z, Bryan JE, Contractor AM, Korabelnikov T, Glass IA, Doherty D, Birth Defects Research Laboratory, Levine JE, Sousa AMM, Chang Q, Bhattacharyya A, Wang D, Werling DM, Zhao X
Neuron 2023 Dec 20;111(24):3988-4005.e11
Neuron 2023 Dec 20;111(24):3988-4005.e11
Alphaherpesvirus-mediated remodeling of the cellular transcriptome results in depletion of m6A-containing transcripts.
Jansens RJJ, Olarerin-George A, Verhamme R, Mirza A, Jaffrey S, Favoreel HW
iScience 2023 Aug 18;26(8):107310
iScience 2023 Aug 18;26(8):107310
Regulation of CCR4-NOT complex deadenylase activity and cellular responses by MK2-dependent phosphorylation of CNOT2.
Suzuki T, Hoshina M, Nishijima S, Hoshina N, Kikuguchi C, Tomohiro T, Fukao A, Fujiwara T, Yamamoto T
RNA biology 2022;19(1):234-246
RNA biology 2022;19(1):234-246
Post-translational control of beige fat biogenesis by PRDM16 stabilization.
Wang Q, Li H, Tajima K, Verkerke ARP, Taxin ZH, Hou Z, Cole JB, Li F, Wong J, Abe I, Pradhan RN, Yamamuro T, Yoneshiro T, Hirschhorn JN, Kajimura S
Nature 2022 Sep;609(7925):151-158
Nature 2022 Sep;609(7925):151-158
The Conserved CNOT1 Interaction Motif of Tristetraprolin Regulates ARE-mRNA Decay Independently of the p38 MAPK-MK2 Kinase Pathway.
Carreño A, Lykke-Andersen J
Molecular and cellular biology 2022 Sep 15;42(9):e0005522
Molecular and cellular biology 2022 Sep 15;42(9):e0005522
Control of immediate early gene expression by CPEB4-repressor complex-mediated mRNA degradation.
Poetz F, Lebedeva S, Schott J, Lindner D, Ohler U, Stoecklin G
Genome biology 2022 Sep 12;23(1):193
Genome biology 2022 Sep 12;23(1):193
UPF1 promotes rapid degradation of m(6)A-containing RNAs.
Boo SH, Ha H, Lee Y, Shin MK, Lee S, Kim YK
Cell reports 2022 May 24;39(8):110861
Cell reports 2022 May 24;39(8):110861
LC3B is an RNA-binding protein to trigger rapid mRNA degradation during autophagy.
Hwang HJ, Ha H, Lee BS, Kim BH, Song HK, Kim YK
Nature communications 2022 Mar 17;13(1):1436
Nature communications 2022 Mar 17;13(1):1436
RNF219 regulates CCR4-NOT function in mRNA translation and deadenylation.
Guénolé A, Velilla F, Chartier A, Rich A, Carvunis AR, Sardet C, Simonelig M, Sobhian B
Scientific reports 2022 Jun 3;12(1):9288
Scientific reports 2022 Jun 3;12(1):9288
TASOR epigenetic repressor cooperates with a CNOT1 RNA degradation pathway to repress HIV.
Matkovic R, Morel M, Lanciano S, Larrous P, Martin B, Bejjani F, Vauthier V, Hansen MMK, Emiliani S, Cristofari G, Gallois-Montbrun S, Margottin-Goguet F
Nature communications 2022 Jan 10;13(1):66
Nature communications 2022 Jan 10;13(1):66
Tex13a Optimizes Sperm Motility via Its Potential Roles in mRNA Turnover.
Li Y, Mi P, Chen X, Wu J, Liu X, Tang Y, Cheng J, Huang Y, Qin W, Cheng CY, Sun F
Frontiers in cell and developmental biology 2021;9:761627
Frontiers in cell and developmental biology 2021;9:761627
The functional characterization of phosphorylation of tristetraprolin at C-terminal NOT1-binding domain.
Hsieh HH, Chen YA, Chang YJ, Wang HH, Yu YH, Lin SW, Huang YJ, Lin S, Chang CJ
Journal of inflammation (London, England) 2021 Jun 5;18(1):22
Journal of inflammation (London, England) 2021 Jun 5;18(1):22
Identification of Phosphorylated Amino Acids in Human TNRC6A C-Terminal Region and Their Effects on the Interaction with the CCR4-NOT Complex.
Munakata F, Suzawa M, Ui-Tei K
Genes 2021 Feb 13;12(2)
Genes 2021 Feb 13;12(2)
RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation.
Poetz F, Corbo J, Levdansky Y, Spiegelhalter A, Lindner D, Magg V, Lebedeva S, Schweiggert J, Schott J, Valkov E, Stoecklin G
Nature communications 2021 Dec 9;12(1):7175
Nature communications 2021 Dec 9;12(1):7175
YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways.
Liu J, Gao M, Xu S, Chen Y, Wu K, Liu H, Wang J, Yang X, Wang J, Liu W, Bao X, Chen J
Cell reports 2020 Sep 8;32(10):108120
Cell reports 2020 Sep 8;32(10):108120
Multivalent Proteins Rapidly and Reversibly Phase-Separate upon Osmotic Cell Volume Change.
Jalihal AP, Pitchiaya S, Xiao L, Bawa P, Jiang X, Bedi K, Parolia A, Cieslik M, Ljungman M, Chinnaiyan AM, Walter NG
Molecular cell 2020 Sep 17;79(6):978-990.e5
Molecular cell 2020 Sep 17;79(6):978-990.e5
RNF219 interacts with CCR4-NOT in regulating stem cell differentiation.
Du H, Chen C, Wang Y, Yang Y, Che Z, Liu X, Meng S, Guo C, Xu M, Fang H, Wang F, Lin C, Luo Z
Journal of molecular cell biology 2020 Oct 26;12(11):894-905
Journal of molecular cell biology 2020 Oct 26;12(11):894-905
Context-dependent functional compensation between Ythdf m(6)A reader proteins.
Lasman L, Krupalnik V, Viukov S, Mor N, Aguilera-Castrejon A, Schneir D, Bayerl J, Mizrahi O, Peles S, Tawil S, Sathe S, Nachshon A, Shani T, Zerbib M, Kilimnik I, Aigner S, Shankar A, Mueller JR, Schwartz S, Stern-Ginossar N, Yeo GW, Geula S, Novershtern N, Hanna JH
Genes & development 2020 Oct 1;34(19-20):1373-1391
Genes & development 2020 Oct 1;34(19-20):1373-1391
Systematic Analysis of Targets of Pumilio-Mediated mRNA Decay Reveals that PUM1 Repression by DNA Damage Activates Translesion Synthesis.
Yamada T, Imamachi N, Imamura K, Taniue K, Kawamura T, Suzuki Y, Nagahama M, Akimitsu N
Cell reports 2020 May 5;31(5):107542
Cell reports 2020 May 5;31(5):107542
Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability.
Mostafa D, Takahashi A, Yanagiya A, Yamaguchi T, Abe T, Kureha T, Kuba K, Kanegae Y, Furuta Y, Yamamoto T, Suzuki T
RNA biology 2020 Mar;17(3):403-416
RNA biology 2020 Mar;17(3):403-416
Regulation of Fetal Genes by Transitions among RNA-Binding Proteins during Liver Development.
Suzuki T, Adachi S, Kikuguchi C, Shibata S, Nishijima S, Kawamoto Y, Iizuka Y, Koseki H, Okano H, Natsume T, Yamamoto T
International journal of molecular sciences 2020 Dec 7;21(23)
International journal of molecular sciences 2020 Dec 7;21(23)
CSDE1 controls gene expression through the miRNA-mediated decay machinery.
Kakumani PK, Harvey LM, Houle F, Guitart T, Gebauer F, Simard MJ
Life science alliance 2020 Apr;3(4)
Life science alliance 2020 Apr;3(4)
UPF1/SMG7-dependent microRNA-mediated gene regulation.
Park J, Seo JW, Ahn N, Park S, Hwang J, Nam JW
Nature communications 2019 Sep 13;10(1):4181
Nature communications 2019 Sep 13;10(1):4181
A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation.
Tavernier SJ, Athanasopoulos V, Verloo P, Behrens G, Staal J, Bogaert DJ, Naesens L, De Bruyne M, Van Gassen S, Parthoens E, Ellyard J, Cappello J, Morris LX, Van Gorp H, Van Isterdael G, Saeys Y, Lamkanfi M, Schelstraete P, Dehoorne J, Bordon V, Van Coster R, Lambrecht BN, Menten B, Beyaert R, Vinuesa CG, Heissmeyer V, Dullaers M, Haerynck F
Nature communications 2019 Oct 21;10(1):4779
Nature communications 2019 Oct 21;10(1):4779
Dynamic Recruitment of Single RNAs to Processing Bodies Depends on RNA Functionality.
Pitchiaya S, Mourao MDA, Jalihal AP, Xiao L, Jiang X, Chinnaiyan AM, Schnell S, Walter NG
Molecular cell 2019 May 2;74(3):521-533.e6
Molecular cell 2019 May 2;74(3):521-533.e6
Endoribonucleolytic Cleavage of m(6)A-Containing RNAs by RNase P/MRP Complex.
Park OH, Ha H, Lee Y, Boo SH, Kwon DH, Song HK, Kim YK
Molecular cell 2019 May 2;74(3):494-507.e8
Molecular cell 2019 May 2;74(3):494-507.e8
Degradation of a Novel DNA Damage Response Protein, Tankyrase 1 Binding Protein 1, following Adenovirus Infection.
Chalabi Hagkarim N, Ryan EL, Byrd PJ, Hollingworth R, Shimwell NJ, Agathanggelou A, Vavasseur M, Kolbe V, Speiseder T, Dobner T, Stewart GS, Grand RJ
Journal of virology 2018 Jun 15;92(12)
Journal of virology 2018 Jun 15;92(12)
Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA.
Rehage N, Davydova E, Conrad C, Behrens G, Maiser A, Stehklein JE, Brenner S, Klein J, Jeridi A, Hoffmann A, Lee E, Dianzani U, Willemsen R, Feederle R, Reiche K, Hackermüller J, Leonhardt H, Sharma S, Niessing D, Heissmeyer V
Nature communications 2018 Jan 19;9(1):299
Nature communications 2018 Jan 19;9(1):299
Translational control of ERK signaling through miRNA/4EHP-directed silencing.
Jafarnejad SM, Chapat C, Matta-Camacho E, Gelbart IA, Hesketh GG, Arguello M, Garzia A, Kim SH, Attig J, Shapiro M, Morita M, Khoutorsky A, Alain T, Gkogkas CG, Stern-Ginossar N, Tuschl T, Gingras AC, Duchaine TF, Sonenberg N
eLife 2018 Feb 7;7
eLife 2018 Feb 7;7
IMP2 and IMP3 cooperate to promote the metastasis of triple-negative breast cancer through destabilization of progesterone receptor.
Kim HY, Ha Thi HT, Hong S
Cancer letters 2018 Feb 28;415:30-39
Cancer letters 2018 Feb 28;415:30-39
Human MARF1 is an endoribonuclease that interacts with the DCP1:2 decapping complex and degrades target mRNAs.
Nishimura T, Fakim H, Brandmann T, Youn JY, Gingras AC, Jinek M, Fabian MR
Nucleic acids research 2018 Dec 14;46(22):12008-12021
Nucleic acids research 2018 Dec 14;46(22):12008-12021
CNOT1 is involved in TTP‑mediated ICAM‑1 and IL‑8 mRNA decay.
Shi JX, Li JS, Hu R, Zhao XC, Liang CC, Li XM, Wang H, Shi Y, Su X
Molecular medicine reports 2018 Aug;18(2):2321-2327
Molecular medicine reports 2018 Aug;18(2):2321-2327
Comprehensive Identification of Nuclear and Cytoplasmic TNRC6A-Associating Proteins.
Suzawa M, Noguchi K, Nishi K, Kozuka-Hata H, Oyama M, Ui-Tei K
Journal of molecular biology 2017 Oct 27;429(21):3319-3333
Journal of molecular biology 2017 Oct 27;429(21):3319-3333
Cap-binding protein 4EHP effects translation silencing by microRNAs.
Chapat C, Jafarnejad SM, Matta-Camacho E, Hesketh GG, Gelbart IA, Attig J, Gkogkas CG, Alain T, Stern-Ginossar N, Fabian MR, Gingras AC, Duchaine TF, Sonenberg N
Proceedings of the National Academy of Sciences of the United States of America 2017 May 23;114(21):5425-5430
Proceedings of the National Academy of Sciences of the United States of America 2017 May 23;114(21):5425-5430
DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs.
Yamaji M, Jishage M, Meyer C, Suryawanshi H, Der E, Yamaji M, Garzia A, Morozov P, Manickavel S, McFarland HL, Roeder RG, Hafner M, Tuschl T
Nature 2017 Mar 23;543(7646):568-572
Nature 2017 Mar 23;543(7646):568-572
The Mammalian Ribo-interactome Reveals Ribosome Functional Diversity and Heterogeneity.
Simsek D, Tiu GC, Flynn RA, Byeon GW, Leppek K, Xu AF, Chang HY, Barna M
Cell 2017 Jun 1;169(6):1051-1065.e18
Cell 2017 Jun 1;169(6):1051-1065.e18
Transcriptional Regulator CNOT3 Defines an Aggressive Colorectal Cancer Subtype.
Cejas P, Cavazza A, Yandava CN, Moreno V, Horst D, Moreno-Rubio J, Burgos E, Mendiola M, Taing L, Goel A, Feliu J, Shivdasani RA
Cancer research 2017 Feb 1;77(3):766-779
Cancer research 2017 Feb 1;77(3):766-779
Alternative splicing of CNOT7 diversifies CCR4-NOT functions.
Chapat C, Chettab K, Simonet P, Wang P, De La Grange P, Le Romancer M, Corbo L
Nucleic acids research 2017 Aug 21;45(14):8508-8523
Nucleic acids research 2017 Aug 21;45(14):8508-8523
Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription.
Hicks JA, Li L, Matsui M, Chu Y, Volkov O, Johnson KC, Corey DR
Cell reports 2017 Aug 15;20(7):1543-1552
Cell reports 2017 Aug 15;20(7):1543-1552
CNOT1 cooperates with LMNA to aggravate osteosarcoma tumorigenesis through the Hedgehog signaling pathway.
Cheng DD, Li J, Li SJ, Yang QC, Fan CY
Molecular oncology 2017 Apr;11(4):388-404
Molecular oncology 2017 Apr;11(4):388-404
CNOT3-Dependent mRNA Deadenylation Safeguards the Pluripotent State.
Zheng X, Yang P, Lackford B, Bennett BD, Wang L, Li H, Wang Y, Miao Y, Foley JF, Fargo DC, Jin Y, Williams CJ, Jothi R, Hu G
Stem cell reports 2016 Nov 8;7(5):897-910
Stem cell reports 2016 Nov 8;7(5):897-910
A widespread sequence-specific mRNA decay pathway mediated by hnRNPs A1 and A2/B1.
Geissler R, Simkin A, Floss D, Patel R, Fogarty EA, Scheller J, Grimson A
Genes & development 2016 May 1;30(9):1070-85
Genes & development 2016 May 1;30(9):1070-85
Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements.
Fu R, Olsen MT, Webb K, Bennett EJ, Lykke-Andersen J
RNA (New York, N.Y.) 2016 Mar;22(3):373-82
RNA (New York, N.Y.) 2016 Mar;22(3):373-82
Codon Usage and 3' UTR Length Determine Maternal mRNA Stability in Zebrafish.
Mishima Y, Tomari Y
Molecular cell 2016 Mar 17;61(6):874-85
Molecular cell 2016 Mar 17;61(6):874-85
Post-transcriptional Control of Tumor Cell Autonomous Metastatic Potential by CCR4-NOT Deadenylase CNOT7.
Faraji F, Hu Y, Yang HH, Lee MP, Winkler GS, Hafner M, Hunter KW
PLoS genetics 2016 Jan;12(1):e1005820
PLoS genetics 2016 Jan;12(1):e1005820
The cAMP pathway regulates mRNA decay through phosphorylation of the RNA-binding protein TIS11b/BRF1.
Rataj F, Planel S, Desroches-Castan A, Le Douce J, Lamribet K, Denis J, Feige JJ, Cherradi N
Molecular biology of the cell 2016 Dec 1;27(24):3841-3854
Molecular biology of the cell 2016 Dec 1;27(24):3841-3854
YTHDF2 destabilizes m(6)A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complex.
Du H, Zhao Y, He J, Zhang Y, Xi H, Liu M, Ma J, Wu L
Nature communications 2016 Aug 25;7:12626
Nature communications 2016 Aug 25;7:12626
CNOT3 suppression promotes necroptosis by stabilizing mRNAs for cell death-inducing proteins.
Suzuki T, Kikuguchi C, Sharma S, Sasaki T, Tokumasu M, Adachi S, Natsume T, Kanegae Y, Yamamoto T
Scientific reports 2015 Oct 6;5:14779
Scientific reports 2015 Oct 6;5:14779
A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.
Cano F, Rapiteanu R, Sebastiaan Winkler G, Lehner PJ
Nature communications 2015 Oct 16;6:8670
Nature communications 2015 Oct 16;6:8670
The eIF4E-Binding Protein 4E-T Is a Component of the mRNA Decay Machinery that Bridges the 5' and 3' Termini of Target mRNAs.
Nishimura T, Padamsi Z, Fakim H, Milette S, Dunham WH, Gingras AC, Fabian MR
Cell reports 2015 Jun 9;11(9):1425-36
Cell reports 2015 Jun 9;11(9):1425-36
ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway.
Adachi S, Homoto M, Tanaka R, Hioki Y, Murakami H, Suga H, Matsumoto M, Nakayama KI, Hatta T, Iemura S, Natsume T
Nucleic acids research 2014 Sep;42(15):10037-49
Nucleic acids research 2014 Sep;42(15):10037-49
Identification of Ccr4-not complex components as regulators of transition from partial to genuine induced pluripotent stem cells.
Kamon M, Katano M, Hiraki-Kamon K, Hishida T, Nakachi Y, Mizuno Y, Okazaki Y, Suzuki A, Hirasaki M, Ueda A, Nishimoto M, Kato H, Okuda A
Stem cells and development 2014 Sep 15;23(18):2170-9
Stem cells and development 2014 Sep 15;23(18):2170-9
CNOT7/hCAF1 is involved in ICAM-1 and IL-8 regulation by tristetraprolin.
Shi JX, Li JS, Hu R, Shi Y, Su X, Li Q, Zhang F
Cellular signalling 2014 Nov;26(11):2390-6
Cellular signalling 2014 Nov;26(11):2390-6
Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis.
Gou LT, Dai P, Yang JH, Xue Y, Hu YP, Zhou Y, Kang JY, Wang X, Li H, Hua MM, Zhao S, Hu SD, Wu LG, Shi HJ, Li Y, Fu XD, Qu LH, Wang ED, Liu MF
Cell research 2014 Jun;24(6):680-700
Cell research 2014 Jun;24(6):680-700
Structural and biochemical insights to the role of the CCR4-NOT complex and DDX6 ATPase in microRNA repression.
Mathys H, Basquin J, Ozgur S, Czarnocki-Cieciura M, Bonneau F, Aartse A, Dziembowski A, Nowotny M, Conti E, Filipowicz W
Molecular cell 2014 Jun 5;54(5):751-65
Molecular cell 2014 Jun 5;54(5):751-65
Roquin promotes constitutive mRNA decay via a conserved class of stem-loop recognition motifs.
Leppek K, Schott J, Reitter S, Poetz F, Hammond MC, Stoecklin G
Cell 2013 May 9;153(4):869-81
Cell 2013 May 9;153(4):869-81
Trypanosome CNOT10 is essential for the integrity of the NOT deadenylase complex and for degradation of many mRNAs.
Färber V, Erben E, Sharma S, Stoecklin G, Clayton C
Nucleic acids research 2013 Jan;41(2):1211-22
Nucleic acids research 2013 Jan;41(2):1211-22
The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex.
Doidge R, Mittal S, Aslam A, Winkler GS
PloS one 2012;7(12):e51331
PloS one 2012;7(12):e51331
Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation.
Zheng X, Dumitru R, Lackford BL, Freudenberg JM, Singh AP, Archer TK, Jothi R, Hu G
Stem cells (Dayton, Ohio) 2012 May;30(5):910-22
Stem cells (Dayton, Ohio) 2012 May;30(5):910-22
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 14276-1-AP(CNOT1 antibody) at dilution of 1:800
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CNOT1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CNOT1. This antibody recognizes human,mouse,rat antigen. The CNOT1 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
