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- References [15]
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- Western blot [1]
- Immunocytochemistry [1]
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- Product number
- 20790-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20790-1-AP, RRID:AB_10755286
- Product name
- KIFC1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated KIFC1 antibody (Cat. #20790-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references ETV1 transcriptional manipulation of KIFC1 regulates the progression of pancreatic cancer.
Meiotic progression in multinuclear mouse spermatocytes without the spindle pole clustering motor protein KIFC1 or cytokinesis forms single-cell late-stage spermatids.
KPNA2 silencing sensitizes triple-negative breast cancer to chemotherapy by promoting multipolar division and suppressing DNA damage repair.
The PLK4 inhibitor RP-1664 demonstrates potent single-agent efficacy in neuroblastoma models through a dual mechanism of sensitivity.
CDK1 promotes the phosphorylation of KIFC1 to regulate the tumorgenicity of endometrial carcinoma.
KIFC1 depends on TRIM37-mediated ubiquitination of PLK4 to promote centrosome amplification in endometrial cancer.
Decreased anterograde transport coupled with sustained retrograde transport contributes to reduced axonal mitochondrial density in tauopathy neurons.
KIFC1 Regulates the Trajectory of Neuronal Migration.
Mechanism of spindle pole organization and instability in human oocytes.
Prognostic Value and Immunological Role of KIFC1 in Hepatocellular Carcinoma.
Mitotic Motor KIFC1 Is an Organizer of Microtubules in the Axon.
Export of membrane proteins from the Golgi complex to the primary cilium requires the kinesin motor, KIFC1.
Proteomic interaction profiling reveals KIFC1 as a factor involved in early targeting of F508del-CFTR to degradation.
Decreased Expression of KIFC1 in Human Testes with Globozoospermic Defects.
Direct Microtubule-Binding by Myosin-10 Orients Centrosomes toward Retraction Fibers and Subcortical Actin Clouds.
Hu F, Bai Z, Wang Y, Tang H, Zhou J
Oncology research 2025;33(7):1723-1737
Oncology research 2025;33(7):1723-1737
Meiotic progression in multinuclear mouse spermatocytes without the spindle pole clustering motor protein KIFC1 or cytokinesis forms single-cell late-stage spermatids.
Simerly C, Hartnett C, Zyhowski A, Robertson E, Harrison C, Cho IK, Easley C 4th, Schatten G
Scientific reports 2025 Oct 17;15(1):36399
Scientific reports 2025 Oct 17;15(1):36399
KPNA2 silencing sensitizes triple-negative breast cancer to chemotherapy by promoting multipolar division and suppressing DNA damage repair.
Cai Y, Du J, Wang H, Shen L, Xu Z, Zhaoxiong Y, Gong Z, Zhu Y, Wu C, Cai J, Zhang P, Chen S, Dai Z, Huang R, Zhu W
Oncogene 2025 Nov;44(44):4254-4270
Oncogene 2025 Nov;44(44):4254-4270
The PLK4 inhibitor RP-1664 demonstrates potent single-agent efficacy in neuroblastoma models through a dual mechanism of sensitivity.
Maris J, Soria-Bretones I, Casás-Selves M, Samanta M, Groff D, Murray J, Fletcher J, Farrel A, Pastor S, Patel K, Goodfellow EG, Li L, Caron C, Shiwram A, Kim H, Henry D, Laterreur N, Bowlan J, Krytska K, Neuhauser S, Stearns T, Schubert J, Wu J, Surrey L, Álvarez-Quilón A, Vallée F, Nejad P, Schonhoft J, Li J, Veloso A, Young J, Hyer M, Morris S, Mossé YP, Marshall G, Haber M, Zimmermann M
Research square 2025 Jul 29;
Research square 2025 Jul 29;
CDK1 promotes the phosphorylation of KIFC1 to regulate the tumorgenicity of endometrial carcinoma.
Lin X, He Y, Liu Y, Zhou H, Xu X, Xu J, Zhou K
Journal of gynecologic oncology 2024 Sep;35(5):e68
Journal of gynecologic oncology 2024 Sep;35(5):e68
KIFC1 depends on TRIM37-mediated ubiquitination of PLK4 to promote centrosome amplification in endometrial cancer.
Zhou K, He Y, Lin X, Zhou H, Xu X, Xu J
Cell death discovery 2024 Sep 30;10(1):419
Cell death discovery 2024 Sep 30;10(1):419
Decreased anterograde transport coupled with sustained retrograde transport contributes to reduced axonal mitochondrial density in tauopathy neurons.
Sabui A, Biswas M, Somvanshi PR, Kandagiri P, Gorla M, Mohammed F, Tammineni P
Frontiers in molecular neuroscience 2022;15:927195
Frontiers in molecular neuroscience 2022;15:927195
KIFC1 Regulates the Trajectory of Neuronal Migration.
Muralidharan H, Guha S, Madugula K, Patil A, Bennison SA, Sun X, Toyo-Oka K, Baas PW
The Journal of neuroscience : the official journal of the Society for Neuroscience 2022 Mar 16;42(11):2149-2165
The Journal of neuroscience : the official journal of the Society for Neuroscience 2022 Mar 16;42(11):2149-2165
Mechanism of spindle pole organization and instability in human oocytes.
So C, Menelaou K, Uraji J, Harasimov K, Steyer AM, Seres KB, Bucevičius J, Lukinavičius G, Möbius W, Sibold C, Tandler-Schneider A, Eckel H, Moltrecht R, Blayney M, Elder K, Schuh M
Science (New York, N.Y.) 2022 Feb 11;375(6581):eabj3944
Science (New York, N.Y.) 2022 Feb 11;375(6581):eabj3944
Prognostic Value and Immunological Role of KIFC1 in Hepatocellular Carcinoma.
Li D, Yu T, Han J, Xu X, Wu J, Song W, Liu G, Zhu H, Zeng Z
Frontiers in molecular biosciences 2021;8:799651
Frontiers in molecular biosciences 2021;8:799651
Mitotic Motor KIFC1 Is an Organizer of Microtubules in the Axon.
Muralidharan H, Baas PW
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 May 15;39(20):3792-3811
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 May 15;39(20):3792-3811
Export of membrane proteins from the Golgi complex to the primary cilium requires the kinesin motor, KIFC1.
Lee SH, Joo K, Jung EJ, Hong H, Seo J, Kim J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Feb;32(2):957-968
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Feb;32(2):957-968
Proteomic interaction profiling reveals KIFC1 as a factor involved in early targeting of F508del-CFTR to degradation.
Canato S, Santos JD, Carvalho AS, Aloria K, Amaral MD, Matthiesen R, Falcao AO, Farinha CM
Cellular and molecular life sciences : CMLS 2018 Dec;75(24):4495-4509
Cellular and molecular life sciences : CMLS 2018 Dec;75(24):4495-4509
Decreased Expression of KIFC1 in Human Testes with Globozoospermic Defects.
Zhi E, Li P, Chen H, Xu P, Zhu X, Zhu Z, He Z, Li Z
Genes 2016 Sep 27;7(10)
Genes 2016 Sep 27;7(10)
Direct Microtubule-Binding by Myosin-10 Orients Centrosomes toward Retraction Fibers and Subcortical Actin Clouds.
Kwon M, Bagonis M, Danuser G, Pellman D
Developmental cell 2015 Aug 10;34(3):323-37
Developmental cell 2015 Aug 10;34(3):323-37
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- rat testis tissue were subjected to SDS PAGE followed by western blot with 20790-1-AP(KIFC1 antibody) at dilution of 1:400
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using KIFC1 antibody 20790-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
