BS60845
antibody from Bioworld Technology, Inc
Targeting: CCL26
eotaxin-3, IMAC, MIP-4a, MIP-4alpha, SCYA26, TSC-1
Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS60845 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- CCL26 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to residues in Human CCL26.
- Description
- Chemokines have been implicated in the regulation of stem/progenitor cell proliferation and movement. C-C chemokines myeloid progenitor inhibitory factor-1 (MPIF)-1 and eotaxin-2 (also known as MPIF-2, CK b-6 or small inducible cytokine A24) both map to chromosome 7q11.23. MPIF-1 has chemotactic activity on dendritic cells derived from either peripheral blood monocytes or cord blood CD34+ progenitors. It is also a potent suppressor of bone marrow low proliferative potential colony-forming cells. Eotaxin-2, which promotes chemotaxis and Ca2+ mobilization in human eosinophils, exerts its activity solely through the CCR3 receptor. In addition, eotaxin-2 lacks suppressive activity against immature subsets of myeloid progenitors, which have been stimulated to proliferate by multiple growth factors. A related C-C chemokine, eotaxin-3, shares only 33% amino acid identity with eotaxin-2, but shares many characteristics with eotaxin-2. Eotaxin-3 induces migration of eosinophils and basophils at a 10-fold higher concentration than eotaxin-2. The gene which encodes eotaxin-3 maps to human chromosome 7q11.23.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of CCL26 pAb at 1:500 dilution Lane1:HEK293T whole cell lysateLane2:RAW264.7 whole cell lysate Lane3:H9C2 whole cell lysate