Antibody data
- Antibody Data
- Antigen structure
- References [20]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 12055-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12055-2-AP, RRID:AB_2301357
- Product name
- RTN3 antibody
- Antibody type
- Polyclonal
- Description
- RTN3 antibody (Cat. #12055-2-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Integrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons.
Senktide blocks aberrant RTN3 interactome to retard memory decline and tau pathology in social isolated Alzheimer's disease mice.
Integrative proteomics highlight presynaptic alterations and c-Jun misactivation as convergent pathomechanisms in ALS.
Adaptive responses of neuronal cells to chronic endoplasmic reticulum (ER) stress.
Melatonin restores endoplasmic reticulum homeostasis to protect injured neurons in a rat model of chronic cervical cord compression.
Deficiency of Perry syndrome-associated p150(Glued) in midbrain dopaminergic neurons leads to progressive neurodegeneration and endoplasmic reticulum abnormalities.
Heteromeric clusters of ubiquitinated ER-shaping proteins drive ER-phagy.
Fibroblast exosomal TFAP2C induced by chitosan oligosaccharides promotes peripheral axon regeneration via the miR-132-5p/CAMKK1 axis.
CCPG1 recognizes endoplasmic reticulum luminal proteins for selective ER-phagy.
Liver X receptor-agonist treatment rescues degeneration in a Drosophila model of hereditary spastic paraplegia.
ER proteins decipher the tubulin code to regulate organelle distribution.
Transverse endoplasmic reticulum expansion in hereditary spastic paraplegia corticospinal axons.
TAOK2 is an ER-localized kinase that catalyzes the dynamic tethering of ER to microtubules.
Quantitative Proteomics and Differential Protein Abundance Analysis after the Depletion of PEX3 from Human Cells Identifies Additional Aspects of Protein Targeting to the ER.
Knockdown of Long Non-Coding RNA AFAP1-AS1 Promoted Viability and Suppressed Death of Cardiomyocytes in Response to I/R In Vitro and In Vivo.
TMCC3 localizes at the three-way junctions for the proper tubular network of the endoplasmic reticulum.
ATL3 Is a Tubular ER-Phagy Receptor for GABARAP-Mediated Selective Autophagy.
Intrinsically Disordered Protein TEX264 Mediates ER-phagy.
The peroxisome biogenesis factors posttranslationally target reticulon homology domain-containing proteins to the endoplasmic reticulum membrane.
Enterovirus 71 protease 2Apro and 3Cpro differentially inhibit the cellular endoplasmic reticulum-associated degradation (ERAD) pathway via distinct mechanisms, and enterovirus 71 hijacks ERAD component p97 to promote its replication.
Zhou X, Lee YK, Li X, Kim H, Sanchez-Priego C, Han X, Tan H, Zhou S, Fu Y, Purtell K, Wang Q, Holstein GR, Tang B, Peng J, Yang N, Yue Z
Nature communications 2024 Apr 10;15(1):3113
Nature communications 2024 Apr 10;15(1):3113
Senktide blocks aberrant RTN3 interactome to retard memory decline and tau pathology in social isolated Alzheimer's disease mice.
Huang HZ, Ai WQ, Wei N, Zhu LS, Liu ZQ, Zhou CW, Deng MF, Zhang WT, Zhang JC, Yang CQ, Hu YZ, Han ZT, Zhang HH, Jia JJ, Wang J, Liu FF, Li K, Xu Q, Yuan M, Man H, Guo Z, Lu Y, Shu K, Zhu LQ, Liu D
Protein & cell 2024 Apr 1;15(4):261-284
Protein & cell 2024 Apr 1;15(4):261-284
Integrative proteomics highlight presynaptic alterations and c-Jun misactivation as convergent pathomechanisms in ALS.
Aly A, Laszlo ZI, Rajkumar S, Demir T, Hindley N, Lamont DJ, Lehmann J, Seidel M, Sommer D, Franz-Wachtel M, Barletta F, Heumos S, Czemmel S, Kabashi E, Ludolph A, Boeckers TM, Henstridge CM, Catanese A
Acta neuropathologica 2023 Sep;146(3):451-475
Acta neuropathologica 2023 Sep;146(3):451-475
Adaptive responses of neuronal cells to chronic endoplasmic reticulum (ER) stress.
Pham TNM, Perumal N, Manicam C, Basoglu M, Eimer S, Fuhrmann DC, Pietrzik CU, Clement AM, Körschgen H, Schepers J, Behl C
Redox biology 2023 Nov;67:102943
Redox biology 2023 Nov;67:102943
Melatonin restores endoplasmic reticulum homeostasis to protect injured neurons in a rat model of chronic cervical cord compression.
Yao M, Pu PM, Li ZY, Zhu K, Zhou LY, Sun YL, Dai YX, Cui XJ, Wang YJ
Journal of pineal research 2023 May;74(4):e12859
Journal of pineal research 2023 May;74(4):e12859
Deficiency of Perry syndrome-associated p150(Glued) in midbrain dopaminergic neurons leads to progressive neurodegeneration and endoplasmic reticulum abnormalities.
Yu J, Yang X, Zheng J, Sgobio C, Sun L, Cai H
NPJ Parkinson's disease 2023 Mar 7;9(1):35
NPJ Parkinson's disease 2023 Mar 7;9(1):35
Heteromeric clusters of ubiquitinated ER-shaping proteins drive ER-phagy.
Foronda H, Fu Y, Covarrubias-Pinto A, Bocker HT, González A, Seemann E, Franzka P, Bock A, Bhaskara RM, Liebmann L, Hoffmann ME, Katona I, Koch N, Weis J, Kurth I, Gleeson JG, Reggiori F, Hummer G, Kessels MM, Qualmann B, Mari M, Dikić I, Hübner CA
Nature 2023 Jun;618(7964):402-410
Nature 2023 Jun;618(7964):402-410
Fibroblast exosomal TFAP2C induced by chitosan oligosaccharides promotes peripheral axon regeneration via the miR-132-5p/CAMKK1 axis.
Zhao Y, Liu J, Liu S, Yang P, Liang Y, Ma J, Mao S, Sun C, Yang Y
Bioactive materials 2023 Aug;26:249-263
Bioactive materials 2023 Aug;26:249-263
CCPG1 recognizes endoplasmic reticulum luminal proteins for selective ER-phagy.
Ishii S, Chino H, Ode KL, Kurikawa Y, Ueda HR, Matsuura A, Mizushima N, Itakura E
Molecular biology of the cell 2023 Apr 1;34(4):ar29
Molecular biology of the cell 2023 Apr 1;34(4):ar29
Liver X receptor-agonist treatment rescues degeneration in a Drosophila model of hereditary spastic paraplegia.
Byrne DJ, Garcia-Pardo ME, Cole NB, Batnasan B, Heneghan S, Sohail A, Blackstone C, O'Sullivan NC
Acta neuropathologica communications 2022 Mar 28;10(1):40
Acta neuropathologica communications 2022 Mar 28;10(1):40
ER proteins decipher the tubulin code to regulate organelle distribution.
Zheng P, Obara CJ, Szczesna E, Nixon-Abell J, Mahalingan KK, Roll-Mecak A, Lippincott-Schwartz J, Blackstone C
Nature 2022 Jan;601(7891):132-138
Nature 2022 Jan;601(7891):132-138
Transverse endoplasmic reticulum expansion in hereditary spastic paraplegia corticospinal axons.
Zhu PP, Hung HF, Batchenkova N, Nixon-Abell J, Henderson J, Zheng P, Renvoisé B, Pang S, Xu CS, Saalfeld S, Funke J, Xie Y, Svara F, Hess HF, Blackstone C
Human molecular genetics 2022 Aug 23;31(16):2779-2795
Human molecular genetics 2022 Aug 23;31(16):2779-2795
TAOK2 is an ER-localized kinase that catalyzes the dynamic tethering of ER to microtubules.
Nourbakhsh K, Ferreccio AA, Bernard MJ, Yadav S
Developmental cell 2021 Dec 20;56(24):3321-3333.e5
Developmental cell 2021 Dec 20;56(24):3321-3333.e5
Quantitative Proteomics and Differential Protein Abundance Analysis after the Depletion of PEX3 from Human Cells Identifies Additional Aspects of Protein Targeting to the ER.
Zimmermann R, Lang S, Lerner M, Förster F, Nguyen D, Helms V, Schrul B
International journal of molecular sciences 2021 Dec 1;22(23)
International journal of molecular sciences 2021 Dec 1;22(23)
Knockdown of Long Non-Coding RNA AFAP1-AS1 Promoted Viability and Suppressed Death of Cardiomyocytes in Response to I/R In Vitro and In Vivo.
Chen Z, Wang X, Hou X, Ding F, Yi K, Zhang P, You T
Journal of cardiovascular translational research 2020 Dec;13(6):996-1007
Journal of cardiovascular translational research 2020 Dec;13(6):996-1007
TMCC3 localizes at the three-way junctions for the proper tubular network of the endoplasmic reticulum.
Wisesa S, Yamamoto Y, Sakisaka T
The Biochemical journal 2019 Nov 15;476(21):3241-3260
The Biochemical journal 2019 Nov 15;476(21):3241-3260
ATL3 Is a Tubular ER-Phagy Receptor for GABARAP-Mediated Selective Autophagy.
Chen Q, Xiao Y, Chai P, Zheng P, Teng J, Chen J
Current biology : CB 2019 Mar 4;29(5):846-855.e6
Current biology : CB 2019 Mar 4;29(5):846-855.e6
Intrinsically Disordered Protein TEX264 Mediates ER-phagy.
Chino H, Hatta T, Natsume T, Mizushima N
Molecular cell 2019 Jun 6;74(5):909-921.e6
Molecular cell 2019 Jun 6;74(5):909-921.e6
The peroxisome biogenesis factors posttranslationally target reticulon homology domain-containing proteins to the endoplasmic reticulum membrane.
Yamamoto Y, Sakisaka T
Scientific reports 2018 Feb 2;8(1):2322
Scientific reports 2018 Feb 2;8(1):2322
Enterovirus 71 protease 2Apro and 3Cpro differentially inhibit the cellular endoplasmic reticulum-associated degradation (ERAD) pathway via distinct mechanisms, and enterovirus 71 hijacks ERAD component p97 to promote its replication.
Wang T, Wang B, Huang H, Zhang C, Zhu Y, Pei B, Cheng C, Sun L, Wang J, Jin Q, Zhao Z
PLoS pathogens 2017 Oct;13(10):e1006674
PLoS pathogens 2017 Oct;13(10):e1006674
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 12055-2-AP(RTN3 antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human gliomas using 12055-2-AP(RTN3 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The RTN3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human RTN3. This antibody recognizes human, mouse, rat antigen. The RTN3 antibody has been validated for the following applications: ELISA, WB, IHC analysis.