HPA037480

antibody from Atlas Antibodies

Targeting: MICU1 CALC, CBARA1, EFHA3, FLJ12684

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

HPA037480

Provider

Atlas Antibodies

Proper citation

Atlas Antibodies Cat#HPA037480, RRID:AB_10696934

Product name

Anti-MICU1

Antibody type

Polyclonal

Description

Polyclonal Antibody against Human MICU1, Gene description: mitochondrial calcium uptake 1, Alternative Gene Names: CALC, CBARA1, EFHA3, FLJ12684, Validated applications: IHC, Uniprot ID: Q9BPX6, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

0.2 mg/ml

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling

The antibody solution should be gently mixed before use.

References

Submitted references

Loss of mitochondrial Ca2+ uptake protein 3 impairs skeletal muscle calcium handling and exercise capacity

Roman B, Mastoor Y, Zhang Y, Gross D, Springer D, Liu C, Glancy B, Murphy E
The Journal of Physiology 2023;602(1):113-128

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MICU1 controls the sensitivity of the mitochondrial Ca2+ uniporter to activators and inhibitors

Rodríguez-Prados M, Huang K, Márta K, Paillard M, Csordás G, Joseph S, Hajnóczky G
Cell Chemical Biology 2023;30(6):606-617.e4

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Ventricular differences in mitochondrial Ca2+ dynamics in murine and porcine hearts

Sung J, Chapoy Villanueva H, Feng F, Araque Igualador A, Prins K, Liu J
Journal of Molecular and Cellular Cardiology 2023;182

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Distinct effects of cardiac mitochondrial calcium uniporter inactivation via EMRE deletion in the short and long term

Chapoy Villanueva H, Sung J, Stevens J, Zhang M, Nelson P, Denduluri L, Feng F, O'Connell T, Townsend D, Liu J
Journal of Molecular and Cellular Cardiology 2023;181

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MICU1 occludes the mitochondrial calcium uniporter in divalent-free conditions

Rodríguez-Prados M, Berezhnaya E, Castromonte M, Menezes-Filho S, Paillard M, Hajnóczky G
Proceedings of the National Academy of Sciences 2023;120(19)

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Mild Traumatic Brain Injury Induces Mitochondrial Calcium Overload and Triggers the Upregulation of NCLX in the Hippocampus.

Mira RG, Quintanilla RA, Cerpa W
Antioxidants (Basel, Switzerland) 2023 Feb 7;12(2)

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Tu Y, Chao F, Tsai M
2023

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Garbincius J, Luongo T, Lambert J, Mangold A, Murray E, Hildebrand A, Jadiya P, Elrod J
2023

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Uncontrolled mitochondrial calcium uptake underlies the pathogenesis of neurodegeneration in MICU1-deficient mice and patients

Singh R, Bartok A, Paillard M, Tyburski A, Elliott M, Hajnóczky G
Science Advances 2022;8(11)

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Capture at the ER-mitochondrial contacts licenses IP3 receptors to stimulate local Ca2+ transfer and oxidative metabolism

Katona M, Bartók Á, Nichtova Z, Csordás G, Berezhnaya E, Weaver D, Ghosh A, Várnai P, Yule D, Hajnóczky G
Nature Communications 2022;13(1)

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Mitochondrial calcium uniporter stabilization preserves energetic homeostasis during Complex I impairment

Balderas E, Eberhardt D, Lee S, Pleinis J, Sommakia S, Balynas A, Yin X, Parker M, Maguire C, Cho S, Szulik M, Bakhtina A, Bia R, Friederich M, Locke T, Van Hove J, Drakos S, Sancak Y, Tristani-Firouzi M, Franklin S, Rodan A, Chaudhuri D
Nature Communications 2022;13(1)

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Sex‐Specific Differences in Endothelial Function Are Driven by Divergent Mitochondrial Ca 2+ Handling

Damacena de Angelis C, Endoni B, Nuno D, Lamping K, Ledolter J, Koval O, Grumbach I
Journal of the American Heart Association 2022;11(13)

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Altered composition of the mitochondrial Ca2+uniporter in the failing human heart

Paillard M, Huang K, Weaver D, Lambert J, Elrod J, Hajnóczky G
Cell Calcium 2022;105

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Mitochondrial Ca2+ uniporter haploinsufficiency enhances long-term potentiation at hippocampal mossy fibre synapses.

Devine MJ, Szulc BR, Howden JH, López-Doménech G, Ruiz A, Kittler JT
Journal of cell science 2022 Nov 15;135(22)

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Sleep/wake calcium dynamics, respiratory function, and ROS production in cardiac mitochondria

Abdel-Rahman E, Hosseiny S, Aaliya A, Adel M, Yasseen B, Al-Okda A, Radwan Y, Saber S, Elkholy N, Elhanafy E, Walker E, Zuniga-Hertz J, Patel H, Griffiths H, Ali S
Journal of Advanced Research 2021;31

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The mitochondrial Ca 2+ uptake regulator, MICU1, is involved in cold stress‐induced ferroptosis

Nakamura T, Ogawa M, Kojima K, Takayanagi S, Ishihara S, Hattori K, Naguro I, Ichijo H
EMBO reports 2021;22(5)

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Changes in Gene Expression of the MCU Complex Are Induced by Electrical Stimulation in Adult Skeletal Muscle

Quezada E, Díaz-Vegas A, Jaimovich E, Casas M
Frontiers in Physiology 2021;11

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Reduced reticulum–mitochondria Ca2+ transfer is an early and reversible trigger of mitochondrial dysfunctions in diabetic cardiomyopathy

Dia M, Gomez L, Thibault H, Tessier N, Leon C, Chouabe C, Ducreux S, Gallo-Bona N, Tubbs E, Bendridi N, Chanon S, Leray A, Belmudes L, Couté Y, Kurdi M, Ovize M, Rieusset J, Paillard M
Basic Research in Cardiology 2020;115(6)

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The conserved aspartate ring of MCU mediates MICU1 binding and regulation in the mitochondrial calcium uniporter complex

Phillips C, Tsai C, Tsai M
eLife 2019;8

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Identification of an ATP-sensitive potassium channel in mitochondria

Paggio A, Checchetto V, Campo A, Menabò R, Di Marco G, Di Lisa F, Szabo I, Rizzuto R, De Stefani D
Nature 2019;572(7771):609-613

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High mitochondrial Ca2+ content increases cancer cell proliferation upon inhibition of mitochondrial permeability transition pore (mPTP)

Marchi S, Vitto V, Patergnani S, Pinton P
Cell Cycle 2019;18(8):914-916

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Akt‐mediated phosphorylation of MICU 1 regulates mitochondrial Ca 2+ levels and tumor growth

Marchi S, Corricelli M, Branchini A, Vitto V, Missiroli S, Morciano G, Perrone M, Ferrarese M, Giorgi C, Pinotti M, Galluzzi L, Kroemer G, Pinton P
The EMBO Journal 2018;38(2)

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Restoring mitochondrial calcium uniporter expression in diabetic mouse heart improves mitochondrial calcium handling and cardiac function

Suarez J, Cividini F, Scott B, Lehmann K, Diaz-Juarez J, Diemer T, Dai A, Suarez J, Jain M, Dillmann W
Journal of Biological Chemistry 2018;293(21):8182-8195

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MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca 2+ and Mn 2+

Kamer K, Sancak Y, Fomina Y, Meisel J, Chaudhuri D, Grabarek Z, Mootha V
Proceedings of the National Academy of Sciences 2018;115(34)

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High‐affinity cooperative Ca2+ binding by MICU1–MICU2 serves as an on–off switch for the uniporter

Kamer K, Grabarek Z, Mootha V
EMBO reports 2017;18(8):1397-1411

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MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration

Antony A, Paillard M, Moffat C, Juskeviciute E, Correnti J, Bolon B, Rubin E, Csordás G, Seifert E, Hoek J, Hajnóczky G
Nature Communications 2016;7(1)

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Strategic Positioning and Biased Activity of the Mitochondrial Calcium Uniporter in Cardiac Muscle

De La Fuente S, Fernandez-Sanz C, Vail C, Agra E, Holmstrom K, Sun J, Mishra J, Williams D, Finkel T, Murphy E, Joseph S, Sheu S, Csordás G
Journal of Biological Chemistry 2016;291(44):23343-23362

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EMRE Is a Matrix Ca 2+ Sensor that Governs Gatekeeping of the Mitochondrial Ca 2+ Uniporter

Vais H, Mallilankaraman K, Mak D, Hoff H, Payne R, Tanis J, Foskett J
Cell Reports 2016;14(3):403-410

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Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum–mitochondria tether

Naon D, Zaninello M, Giacomello M, Varanita T, Grespi F, Lakshminaranayan S, Serafini A, Semenzato M, Herkenne S, Hernández-Alvarez M, Zorzano A, De Stefani D, Dorn G, Scorrano L
Proceedings of the National Academy of Sciences 2016;113(40):11249-11254

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Structure and function of the N‐terminal domain of the human mitochondrial calcium uniporter

Lee Y, Min C, Kim T, Song H, Lim Y, Kim D, Shin K, Kang M, Kang J, Youn H, Lee J, An J, Park K, Lim J, Kim J, Kim J, Park Z, Kim Y, Wang J, Kim D, Eom S
EMBO reports 2015;16(10):1318-1333

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Directed evolution of APEX2 for electron microscopy and proximity labeling

Lam S, Martell J, Kamer K, Deerinck T, Ellisman M, Mootha V, Ting A
Nature Methods 2014;12(1):51-54

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Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling

Logan C, Szabadkai G, Sharpe J, Parry D, Torelli S, Childs A, Kriek M, Phadke R, Johnson C, Roberts N, Bonthron D, Pysden K, Whyte T, Munteanu I, Foley A, Wheway G, Szymanska K, Natarajan S, Abdelhamed Z, Morgan J, Roper H, Santen G, Niks E, van der Pol W, Lindhout D, Raffaello A, De Stefani D, den Dunnen J, Sun Y, Ginjaar I, Sewry C, Hurles M, Rizzuto R, Duchen M, Muntoni F, Sheridan E
Nature Genetics 2013;46(2):188-193