Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS1290 - Provider product page
- Provider
- Bioworld Technology, Inc
- Proper citation
- Bioworld Technology Cat#BS1290, RRID:AB_1663404
- Product name
- PDGF B (L48) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 21-70 of Human PDGF-B.
- Description
- PDGF is a mitogen for mesenchyme- and glia-derived cells. It consists of two disulfide-bonded polypeptide chains, A and B, and occurs as three isoforms, PDGF AA, PDGF AB and PDGF BB. The three isoforms bind with different affinities to two receptor types, Ï« and ÉÇ, which are structurally related and endowed with protein-tyrosine kinase domains. Ligand binding induces activation of the receptor kinases by formation of receptor dimers; the A subunit of PDGF binds only to Ï« receptors with high affinity, whereas the B subunit can bind to both Ï« and ÉÇ receptors. Evidence suggests that PDGF may function as a neurotrophic factor.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of PDGFB (L48) pAb at 1:500 dilutionLane1:HEK293T cell lysateLane2:Hela cell lysateLane3:Mouse liver tissue lysateLane4:Rat liver tissue lysateLane5:Mouse kidney tissue lysateLane6:Rat kidney tissue lysate