FAB195F-025
antibody from R&D Systems
Targeting: CCR6
BN-1, CD196, CKR-L3, CMKBR6, DCR2, DRY-6, GPR-CY4, GPR29, STRL22
Antibody data
- Antibody Data
- Antigen structure
- References [11]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- FAB195F-025 - Provider product page
- Provider
- R&D Systems
- Product name
- Human CCR6 Fluorescein-conjugated Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from ascites. Detects human CCR6. Stains human CCR6 transfectants but not the parental cell line in flow cytometry. Does not cross-react with transfectants expressing human CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CXCR1, CXCR2, CXCR3, CXCR4, or STRL33.
- Reactivity
- Human
- Host
- Mouse
- Antigen sequence
P51684
- Isotype
- IgG
- Antibody clone number
- 53103
- Vial size
- 25 Tests
- Storage
- Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.
Submitted references Glatiramer Acetate, Dimethyl Fumarate, and Monomethyl Fumarate Upregulate the Expression of CCR10 on the Surface of Natural Killer Cells and Enhance Their Chemotaxis and Cytotoxicity.
IL-11 Induces Th17 Cell Responses in Patients with Early Relapsing-Remitting Multiple Sclerosis.
CCR2(+)CCR5(+) T cells produce matrix metalloproteinase-9 and osteopontin in the pathogenesis of multiple sclerosis.
Identification of human NK17/NK1 cells.
Characterization of circulating dendritic cells in melanoma: role of CCR6 in plasmacytoid dendritic cell recruitment to the tumor.
Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2.
Evidence for a cross-talk between human neutrophils and Th17 cells.
HIV-1 infection is characterized by profound depletion of CD161+ Th17 cells and gradual decline in regulatory T cells.
Lung myeloid dendritic cells coordinately induce TH1 and TH17 responses in human emphysema.
Expression and role of CCR6/CCL20 chemokine axis in pulmonary sarcoidosis.
CCR6 colocalizes with CD18 and enhances adhesion to activated endothelial cells in CCR6-transduced Jurkat T cells.
Maghazachi AA, Sand KL, Al-Jaderi Z
Frontiers in immunology 2016;7:437
Frontiers in immunology 2016;7:437
IL-11 Induces Th17 Cell Responses in Patients with Early Relapsing-Remitting Multiple Sclerosis.
Zhang X, Tao Y, Chopra M, Dujmovic-Basuroski I, Jin J, Tang Y, Drulovic J, Markovic-Plese S
Journal of immunology (Baltimore, Md. : 1950) 2015 Jun 1;194(11):5139-49
Journal of immunology (Baltimore, Md. : 1950) 2015 Jun 1;194(11):5139-49
CCR2(+)CCR5(+) T cells produce matrix metalloproteinase-9 and osteopontin in the pathogenesis of multiple sclerosis.
Sato W, Tomita A, Ichikawa D, Lin Y, Kishida H, Miyake S, Ogawa M, Okamoto T, Murata M, Kuroiwa Y, Aranami T, Yamamura T
Journal of immunology (Baltimore, Md. : 1950) 2012 Nov 15;189(10):5057-65
Journal of immunology (Baltimore, Md. : 1950) 2012 Nov 15;189(10):5057-65
Identification of human NK17/NK1 cells.
Pandya AD, Al-Jaderi Z, Høglund RA, Holmøy T, Harbo HF, Norgauer J, Maghazachi AA
PloS one 2011;6(10):e26780
PloS one 2011;6(10):e26780
Characterization of circulating dendritic cells in melanoma: role of CCR6 in plasmacytoid dendritic cell recruitment to the tumor.
Charles J, Di Domizio J, Salameire D, Bendriss-Vermare N, Aspord C, Muhammad R, Lefebvre C, Plumas J, Leccia MT, Chaperot L
The Journal of investigative dermatology 2010 Jun;130(6):1646-56
The Journal of investigative dermatology 2010 Jun;130(6):1646-56
Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2.
Röhrl J, Yang D, Oppenheim JJ, Hehlgans T
Journal of immunology (Baltimore, Md. : 1950) 2010 Jun 15;184(12):6688-94
Journal of immunology (Baltimore, Md. : 1950) 2010 Jun 15;184(12):6688-94
Evidence for a cross-talk between human neutrophils and Th17 cells.
Pelletier M, Maggi L, Micheletti A, Lazzeri E, Tamassia N, Costantini C, Cosmi L, Lunardi C, Annunziato F, Romagnani S, Cassatella MA
Blood 2010 Jan 14;115(2):335-43
Blood 2010 Jan 14;115(2):335-43
HIV-1 infection is characterized by profound depletion of CD161+ Th17 cells and gradual decline in regulatory T cells.
Prendergast A, Prado JG, Kang YH, Chen F, Riddell LA, Luzzi G, Goulder P, Klenerman P
AIDS (London, England) 2010 Feb 20;24(4):491-502
AIDS (London, England) 2010 Feb 20;24(4):491-502
Lung myeloid dendritic cells coordinately induce TH1 and TH17 responses in human emphysema.
Shan M, Cheng HF, Song LZ, Roberts L, Green L, Hacken-Bitar J, Huh J, Bakaeen F, Coxson HO, Storness-Bliss C, Ramchandani M, Lee SH, Corry DB, Kheradmand F
Science translational medicine 2009 Oct 28;1(4):4ra10
Science translational medicine 2009 Oct 28;1(4):4ra10
Expression and role of CCR6/CCL20 chemokine axis in pulmonary sarcoidosis.
Facco M, Baesso I, Miorin M, Bortoli M, Cabrelle A, Boscaro E, Gurrieri C, Trentin L, Zambello R, Calabrese F, Cassatella MA, Semenzato G, Agostini C
Journal of leukocyte biology 2007 Oct;82(4):946-55
Journal of leukocyte biology 2007 Oct;82(4):946-55
CCR6 colocalizes with CD18 and enhances adhesion to activated endothelial cells in CCR6-transduced Jurkat T cells.
Maki W, Morales RE, Carroll VA, Telford WG, Knibbs RN, Stoolman LM, Hwang ST
Journal of immunology (Baltimore, Md. : 1950) 2002 Sep 1;169(5):2346-53
Journal of immunology (Baltimore, Md. : 1950) 2002 Sep 1;169(5):2346-53
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of CCR6 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human CD19 APC-conjugated Monoclonal Antibody (Catalog # FAB4867A) and either (A) Mouse Anti-Human CCR6 Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB195F) or (B) Mouse IgG2B Fluorescein Isotype Control (Catalog # IC0041F). View our protocol for Staining Membrane-associated Proteins.