353434
antibody from BioLegend
Targeting: CCR6
BN-1, CD196, CKR-L3, CMKBR6, DCR2, DRY-6, GPR-CY4, GPR29, STRL22
Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 353434 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#353434, RRID:AB_2566276
- Product name
- Alexa Fluor® 700 anti-human CD196 (CCR6)
- Antibody type
- Monoclonal
- Antigen
- CCR6-transfected cells
- Description
- CCR6, also known as CD196, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the β defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Near infrared dye
- Antibody clone number
- G034E3
- Vial size
- 100 tests
- Storage
- 2°C-8°C
- Handling
- Ambient RT
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood lymphocytes were stained with CD19 FITC and CD196 (clone G034E3) Alexa Fluor® 700 (top) or mouse IgG2b, κ Alexa Fluor® 700 isotype control (bottom).
- Conjugate
- Near infrared dye