60090AD

antibody from STEMCELL Technologies Inc

Targeting: CCR6 BN-1, CD196, CKR-L3, CMKBR6, DCR2, DRY-6, GPR-CY4, GPR29, STRL22

Flow cytometry (Recommended by provider)

Antibody Data

Product number

60090AD

Provider

STEMCELL Technologies Inc

Product name

Anti-Human CD196 (CCR6) Antibody, Clone G034E3, Alexa Fluor® 488

Antibody type

Monoclonal

Description

The G034E3 antibody reacts with an extracellular epitope on human CD196 (CCR6). CD196 is an ~42 kDa seven-pass G protein-coupled transmembrane chemokine receptor expressed predominantly on the surface of immature dendritic, B, and memory T cells, but also on natural killer and Langerhans cells. The chemokine CCL20 (MIP-3?) has been identified as a ligand for CD196 and its binding induces an increase in the intracellular Ca++ ion concentration. CD196 may play roles in B cell maturation and the differentiation of B and T cells, and appears to be involved in chemotactic recruitment of CD196-expressing cells during the immune and inflammatory responses, a function implicated in the pathogenesis of diseases such as rheumatoid arthritis, inflammatory bowel disease and psoriasis. Abundant expression of CD196 is also observed on B cells of patients with progressive chronic lymphocytic leukemia.

Reactivity

Human

Isotype

IgG

Vial size

100 Tests

Storage

2 - 8°C