60090FI.1
antibody from STEMCELL Technologies Inc
Targeting: CCR6
BN-1, CD196, CKR-L3, CMKBR6, DCR2, DRY-6, GPR-CY4, GPR29, STRL22
Antibody data
- Antibody Data
- Antigen structure
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- Product number
- 60090FI.1 - Provider product page
- Provider
- STEMCELL Technologies Inc
- Product name
- Anti-Human CD196 (CCR6) Antibody, Clone G034E3, FITC
- Antibody type
- Monoclonal
- Description
- The G034E3 antibody reacts with an extracellular epitope on human CD196 (CCR6). CD196 is an ~42 kDa seven-pass G protein-coupled transmembrane chemokine receptor expressed predominantly on the surface of immature dendritic, B, and memory T cells, but also on natural killer and Langerhans cells. The chemokine CCL20 (MIP-3?) has been identified as a ligand for CD196 and its binding induces an increase in the intracellular Ca++ ion concentration. CD196 may play roles in B cell maturation and the differentiation of B and T cells, and appears to be involved in chemotactic recruitment of CD196-expressing cells during the immune and inflammatory responses, a function implicated in the pathogenesis of diseases such as rheumatoid arthritis, inflammatory bowel disease and psoriasis. Abundant expression of CD196 is also observed on B cells of patients with progressive chronic lymphocytic leukemia.
- Reactivity
- Human
- Isotype
- IgG
- Vial size
- 25 Tests
- Storage
- 2 - 8°C
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