335503
antibody from BioLegend
Targeting: CCR6
BN-1, CD196, CKR-L3, CMKBR6, DCR2, DRY-6, GPR-CY4, GPR29, STRL22
Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations [0]
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- Product number
- 335503 - Provider product page
- Provider
- BioLegend
- Product name
- Alexa Fluor® 647 anti-human CD196 (CCR6) [TG7/CCR6]
- Antibody type
- Monoclonal
- Antigen
- CCR6 transfectants
- Description
- CCR6 is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells (1). CCR6 binds CCL20, although members of the β defensin family also bind CCR6 with a lower affinity (2). CCR6 positive cells and its ligand CCL20 have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers patches (PPs) and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures (3). In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin (4), and CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis(5) and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues (6).
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Red dye
- Isotype
- IgG
- Vial size
- 25 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Submitted references IL-9 as a mediator of Th17-driven inflammatory disease.
Nowak EC, Weaver CT, Turner H, Begum-Haque S, Becher B, Schreiner B, Coyle AJ, Kasper LH, Noelle RJ
The Journal of experimental medicine 2009 Aug 3;206(8):1653-60
The Journal of experimental medicine 2009 Aug 3;206(8):1653-60
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