335507

antibody from BioLegend
Targeting: CCR6 BN-1, CD196, CKR-L3, CMKBR6, DCR2, DRY-6, GPR-CY4, GPR29, STRL22
Provider product page for 335507
Flow cytometry

Antibody data

Product number
335507 - Provider product page
Provider
BioLegend
Product name
PE anti-human CD196 (CCR6)
Antibody type
Monoclonal
Antigen
CCR6 transfectants
Description
CCR6 is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells (1). CCR6 binds CCL20, although members of the β defensin family also bind CCR6 with a lower affinity (2). CCR6 positive cells and its ligand CCL20 have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers patches (PPs) and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures (3). In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin (4), and CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis(5) and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues (6).
Reactivity
Human
Host
Mouse
Conjugate
Yellow dye
Isotype
IgG
Vial size
25 µg
Concentration
0.2 mg/ml
Storage
The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
CCR6 protein structure - 335507 shown in red.