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LearnMAB195
antibody from R&D Systems
Targeting: CCR6
BN-1, CD196, CKR-L3, CMKBR6, DCR2, DRY-6, GPR-CY4, GPR29, STRL22
ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [34]
- Comments [0]
- Validations [0]
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- Product number
- MAB195 - Provider product page
- Provider
- R&D Systems
- Product name
- Anti-Human CCR6 Monoclonal Antibody (Clone 53103)
- Antibody type
- Monoclonal
- Antigen
- NS0 mouse myeloma cell line transfected with human CCR6, Met1-Met374
- Description
- Protein A or G purified from ascites
- Reactivity
- Human
- Host
- Mouse
- Antigen sequence
P51684- Isotype
- IgG
- Vial size
- 100 µg
Submitted references The Cerebellum of Patients with Steatohepatitis Shows Lymphocyte Infiltration, Microglial Activation and Loss of Purkinje and Granular Neurons.
CCR6 is required for ligand-induced CatSper activation in human sperm.
Impairment of CCR6+ and CXCR3+ Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization.
Analysis of the cross-talk of Epstein-Barr virus-infected B cells with T cells in the marmoset.
Role of CCL20/CCR6 and the ERK signaling pathway in lung adenocarcinoma.
Circulating CCL20 as a New Biomarker of Abdominal Aortic Aneurysm.
Skewing toward Treg and Th2 responses is a characteristic feature of sustained remission in ANCA-positive granulomatosis with polyangiitis.
CCR6 expression in colon cancer is associated with advanced disease and supports epithelial-to-mesenchymal transition.
CCR6 is a prognostic marker for overall survival in patients with colorectal cancer, and its overexpression enhances metastasis in vivo.
CCR6, the sole receptor for the chemokine CCL20, promotes spontaneous intestinal tumorigenesis.
Oxygen regulates human cytotrophoblast migration by controlling chemokine and receptor expression.
Increased Th17/Treg ratio in chronic liver GVHD.
Increased plasmacytoid dendritic cells and RORγt-expressing immune effectors in cutaneous acute graft-versus-host disease.
Blood CD4+CD45RO+CXCR5+ T cells are decreased but partially functional in signal transducer and activator of transcription 3 deficiency.
Identification of human NK17/NK1 cells.
CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells.
IL-22, but not IL-17, dominant environment in cutaneous T-cell lymphoma.
Characterization of circulating dendritic cells in melanoma: role of CCR6 in plasmacytoid dendritic cell recruitment to the tumor.
Intratumoral induction of CD103 triggers tumor-specific CTL function and CCR5-dependent T-cell retention.
Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells.
Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells.
Cutting edge: nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis.
Cutting edge: nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis.
Characterisation of dendritic cell subsets in lung cancer micro-environments.
Paired synovium and lymph nodes from rheumatoid arthritis patients differ in dendritic cell and chemokine expression.
Plasma cell-like morphology of Th1-cytokine-producing cells associated with the loss of CD3 expression.
Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses.
Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands.
Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands.
Possible link between unique chemokine and homing receptor expression at diagnosis and relapse location in a patient with childhood T-ALL.
CCR6 colocalizes with CD18 and enhances adhesion to activated endothelial cells in CCR6-transduced Jurkat T cells.
CCR6 colocalizes with CD18 and enhances adhesion to activated endothelial cells in CCR6-transduced Jurkat T cells.
Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire.
Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire.
Balzano T, Forteza J, Molina P, Giner J, Monzó A, Sancho-Jiménez J, Urios A, Montoliu C, Felipo V
Scientific reports 2018 Feb 14;8(1):3004
Scientific reports 2018 Feb 14;8(1):3004
CCR6 is required for ligand-induced CatSper activation in human sperm.
Diao R, Wang T, Fok KL, Li X, Ruan Y, Yu MK, Cheng Y, Chen Y, Chen H, Mou L, Cai X, Wang Y, Cai Z, Zeng X, Chan HC
Oncotarget 2017 Oct 31;8(53):91445-91458
Oncotarget 2017 Oct 31;8(53):91445-91458
Impairment of CCR6+ and CXCR3+ Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization.
Cecchinato V, Bernasconi E, Speck RF, Proietti M, Sauermann U, D'Agostino G, Danelon G, Rezzonico Jost T, Grassi F, Raeli L, Schöni-Affolter F, Stahl-Hennig C, Uguccioni M, Swiss HIV Cohort Study.
Journal of immunology (Baltimore, Md. : 1950) 2017 Jan 1;198(1):184-195
Journal of immunology (Baltimore, Md. : 1950) 2017 Jan 1;198(1):184-195
Analysis of the cross-talk of Epstein-Barr virus-infected B cells with T cells in the marmoset.
Dunham J, van Driel N, Eggen BJ, Paul C, 't Hart BA, Laman JD, Kap YS
Clinical & translational immunology 2017 Feb;6(2):e127
Clinical & translational immunology 2017 Feb;6(2):e127
Role of CCL20/CCR6 and the ERK signaling pathway in lung adenocarcinoma.
Zhang XP, Hu ZJ, Meng AH, Duan GC, Zhao QT, Yang J
Oncology letters 2017 Dec;14(6):8183-8189
Oncology letters 2017 Dec;14(6):8183-8189
Circulating CCL20 as a New Biomarker of Abdominal Aortic Aneurysm.
Soto B, Gallastegi-Mozos T, Rodríguez C, Martínez-González J, Escudero JR, Vila L, Camacho M
Scientific reports 2017 Dec 11;7(1):17331
Scientific reports 2017 Dec 11;7(1):17331
Skewing toward Treg and Th2 responses is a characteristic feature of sustained remission in ANCA-positive granulomatosis with polyangiitis.
Szczeklik W, Jakieła B, Wawrzycka-Adamczyk K, Sanak M, Hubalewska-Mazgaj M, Padjas A, Surmiak M, Szczeklik K, Sznajd J, Musiał J
European journal of immunology 2017 Apr;47(4):724-733
European journal of immunology 2017 Apr;47(4):724-733
CCR6 expression in colon cancer is associated with advanced disease and supports epithelial-to-mesenchymal transition.
Kapur N, Mir H, Clark Iii CE, Krishnamurti U, Beech DJ, Lillard JW, Singh S
British journal of cancer 2016 Jun 14;114(12):1343-51
British journal of cancer 2016 Jun 14;114(12):1343-51
CCR6 is a prognostic marker for overall survival in patients with colorectal cancer, and its overexpression enhances metastasis in vivo.
Liu J, Ke F, Xu Z, Liu Z, Zhang L, Yan S, Wang Z, Wang H, Wang H
PloS one 2014;9(6):e101137
PloS one 2014;9(6):e101137
CCR6, the sole receptor for the chemokine CCL20, promotes spontaneous intestinal tumorigenesis.
Nandi B, Pai C, Huang Q, Prabhala RH, Munshi NC, Gold JS
PloS one 2014;9(5):e97566
PloS one 2014;9(5):e97566
Oxygen regulates human cytotrophoblast migration by controlling chemokine and receptor expression.
Schanz A, Red-Horse K, Hess AP, Baston-Büst DM, Heiss C, Krüssel JS
Placenta 2014 Dec;35(12):1089-94
Placenta 2014 Dec;35(12):1089-94
Increased Th17/Treg ratio in chronic liver GVHD.
Malard F, Bossard C, Brissot E, Chevallier P, Guillaume T, Delaunay J, Mosnier JF, Moreau P, Grégoire M, Gaugler B, Mohty M
Bone marrow transplantation 2014 Apr;49(4):539-44
Bone marrow transplantation 2014 Apr;49(4):539-44
Increased plasmacytoid dendritic cells and RORγt-expressing immune effectors in cutaneous acute graft-versus-host disease.
Malard F, Bossard C, Brissot E, Chevallier P, Guillaume T, Delaunay J, Mosnier JF, Moreau P, Grégoire M, Gaugler B, Mohty M
Journal of leukocyte biology 2013 Dec;94(6):1337-43
Journal of leukocyte biology 2013 Dec;94(6):1337-43
Blood CD4+CD45RO+CXCR5+ T cells are decreased but partially functional in signal transducer and activator of transcription 3 deficiency.
Mazerolles F, Picard C, Kracker S, Fischer A, Durandy A
The Journal of allergy and clinical immunology 2013 Apr;131(4):1146-56, 1156.e1-5
The Journal of allergy and clinical immunology 2013 Apr;131(4):1146-56, 1156.e1-5
Identification of human NK17/NK1 cells.
Pandya AD, Al-Jaderi Z, Høglund RA, Holmøy T, Harbo HF, Norgauer J, Maghazachi AA
PloS one 2011;6(10):e26780
PloS one 2011;6(10):e26780
CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells.
Kim S, Lewis C, Nadel JA
Journal of immunology (Baltimore, Md. : 1950) 2011 Mar 15;186(6):3392-400
Journal of immunology (Baltimore, Md. : 1950) 2011 Mar 15;186(6):3392-400
IL-22, but not IL-17, dominant environment in cutaneous T-cell lymphoma.
Miyagaki T, Sugaya M, Suga H, Kamata M, Ohmatsu H, Fujita H, Asano Y, Tada Y, Kadono T, Sato S
Clinical cancer research : an official journal of the American Association for Cancer Research 2011 Dec 15;17(24):7529-38
Clinical cancer research : an official journal of the American Association for Cancer Research 2011 Dec 15;17(24):7529-38
Characterization of circulating dendritic cells in melanoma: role of CCR6 in plasmacytoid dendritic cell recruitment to the tumor.
Charles J, Di Domizio J, Salameire D, Bendriss-Vermare N, Aspord C, Muhammad R, Lefebvre C, Plumas J, Leccia MT, Chaperot L
The Journal of investigative dermatology 2010 Jun;130(6):1646-56
The Journal of investigative dermatology 2010 Jun;130(6):1646-56
Intratumoral induction of CD103 triggers tumor-specific CTL function and CCR5-dependent T-cell retention.
Franciszkiewicz K, Le Floc'h A, Jalil A, Vigant F, Robert T, Vergnon I, Mackiewicz A, Benihoud K, Validire P, Chouaib S, Combadière C, Mami-Chouaib F
Cancer research 2009 Aug 1;69(15):6249-55
Cancer research 2009 Aug 1;69(15):6249-55
Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells.
Kang SG, Lim HW, Andrisani OM, Broxmeyer HE, Kim CH
Journal of immunology (Baltimore, Md. : 1950) 2007 Sep 15;179(6):3724-33
Journal of immunology (Baltimore, Md. : 1950) 2007 Sep 15;179(6):3724-33
Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells.
Kang SG, Lim HW, Andrisani OM, Broxmeyer HE, Kim CH
Journal of immunology (Baltimore, Md. : 1950) 2007 Sep 15;179(6):3724-33
Journal of immunology (Baltimore, Md. : 1950) 2007 Sep 15;179(6):3724-33
Cutting edge: nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis.
Marchal-Sommé J, Uzunhan Y, Marchand-Adam S, Valeyre D, Soumelis V, Crestani B, Soler P
Journal of immunology (Baltimore, Md. : 1950) 2006 May 15;176(10):5735-9
Journal of immunology (Baltimore, Md. : 1950) 2006 May 15;176(10):5735-9
Cutting edge: nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis.
Marchal-Sommé J, Uzunhan Y, Marchand-Adam S, Valeyre D, Soumelis V, Crestani B, Soler P
Journal of immunology (Baltimore, Md. : 1950) 2006 May 15;176(10):5735-9
Journal of immunology (Baltimore, Md. : 1950) 2006 May 15;176(10):5735-9
Characterisation of dendritic cell subsets in lung cancer micro-environments.
Bergeron A, El-Hage F, Kambouchner M, Lecossier D, Tazi A
The European respiratory journal 2006 Dec;28(6):1170-7
The European respiratory journal 2006 Dec;28(6):1170-7
Paired synovium and lymph nodes from rheumatoid arthritis patients differ in dendritic cell and chemokine expression.
Page G, Miossec P
The Journal of pathology 2004 Sep;204(1):28-38
The Journal of pathology 2004 Sep;204(1):28-38
Plasma cell-like morphology of Th1-cytokine-producing cells associated with the loss of CD3 expression.
Page G, Sattler A, Kersten S, Thiel A, Radbruch A, Miossec P
The American journal of pathology 2004 Feb;164(2):409-17
The American journal of pathology 2004 Feb;164(2):409-17
Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses.
Lim HW, Hillsamer P, Kim CH
The Journal of clinical investigation 2004 Dec;114(11):1640-9
The Journal of clinical investigation 2004 Dec;114(11):1640-9
Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands.
Kohrgruber N, Gröger M, Meraner P, Kriehuber E, Petzelbauer P, Brandt S, Stingl G, Rot A, Maurer D
Journal of immunology (Baltimore, Md. : 1950) 2004 Dec 1;173(11):6592-602
Journal of immunology (Baltimore, Md. : 1950) 2004 Dec 1;173(11):6592-602
Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands.
Kohrgruber N, Gröger M, Meraner P, Kriehuber E, Petzelbauer P, Brandt S, Stingl G, Rot A, Maurer D
Journal of immunology (Baltimore, Md. : 1950) 2004 Dec 1;173(11):6592-602
Journal of immunology (Baltimore, Md. : 1950) 2004 Dec 1;173(11):6592-602
Possible link between unique chemokine and homing receptor expression at diagnosis and relapse location in a patient with childhood T-ALL.
Annels NE, Willemze AJ, van der Velden VH, Faaij CM, van Wering E, Sie-Go DM, Egeler RM, van Tol MJ, Révész T
Blood 2004 Apr 1;103(7):2806-8
Blood 2004 Apr 1;103(7):2806-8
CCR6 colocalizes with CD18 and enhances adhesion to activated endothelial cells in CCR6-transduced Jurkat T cells.
Maki W, Morales RE, Carroll VA, Telford WG, Knibbs RN, Stoolman LM, Hwang ST
Journal of immunology (Baltimore, Md. : 1950) 2002 Sep 1;169(5):2346-53
Journal of immunology (Baltimore, Md. : 1950) 2002 Sep 1;169(5):2346-53
CCR6 colocalizes with CD18 and enhances adhesion to activated endothelial cells in CCR6-transduced Jurkat T cells.
Maki W, Morales RE, Carroll VA, Telford WG, Knibbs RN, Stoolman LM, Hwang ST
Journal of immunology (Baltimore, Md. : 1950) 2002 Sep 1;169(5):2346-53
Journal of immunology (Baltimore, Md. : 1950) 2002 Sep 1;169(5):2346-53
Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire.
Campbell JJ, Qin S, Unutmaz D, Soler D, Murphy KE, Hodge MR, Wu L, Butcher EC
Journal of immunology (Baltimore, Md. : 1950) 2001 Jun 1;166(11):6477-82
Journal of immunology (Baltimore, Md. : 1950) 2001 Jun 1;166(11):6477-82
Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire.
Campbell JJ, Qin S, Unutmaz D, Soler D, Murphy KE, Hodge MR, Wu L, Butcher EC
Journal of immunology (Baltimore, Md. : 1950) 2001 Jun 1;166(11):6477-82
Journal of immunology (Baltimore, Md. : 1950) 2001 Jun 1;166(11):6477-82
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