21279-1-AP

antibody from Proteintech Group

Targeting: ZP3 ZP3-372, ZP3-424, ZP3A, ZP3B, ZPC

Provider product page for 21279-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [21]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 21279-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#21279-1-AP, RRID:AB_11124319
Product name: ZP3 antibody
Antibody type: Polyclonal
Description: ZP3 antibody (Cat. #21279-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ZP3 protein structure - 21279-1-AP shown in red.

Submitted references ZP3 promotes hepatocellular carcinoma progression via the Notch signaling pathway and is associated with the tumor microenvironment and immunotherapy response.

Qu C, Yan X, Li Y
World journal of surgical oncology 2026 Feb 9;24(1)

Carboplatin and paclitaxel induced-gonadotoxicity on the ovarian reserve of young breast cancer patients with BRCA1 mutation.

Dias Nunes J, Ntemou E, Van den Steen G, Findikli N, Fastrez M, Delbaere A, Lambertini M, Devos M, Demeestere I
Human reproduction (Oxford, England) 2025 Sep 1;40(9):1709-1719

Dominant follicle-targeted nanocarriers for GH delivery to alleviate premature ovarian insufficiency.

Yang S, Sun Y, Luo W, Zhou X, Gu X, Zhang W, Zhu H, Wu W, Wu X, Yu M, Wang S
Materials today. Bio 2025 Aug;33:101930

A compound heterozygous mutation in ZP1 and two novel heterozygous cis mutations in ZP3 causes infertility in women presenting with empty follicle syndrome.

Wang X, Liu Y, Yuan G, Yang J, Liu X, Chen S, Dou H, Lu P, Han L, Li D, Hao C
Journal of ovarian research 2025 Apr 26;18(1):86

Transglutaminase 2 reduces the polyspermy of porcine oocytes by promoting the hardening of zona pellucida.

Cui Z, Zhang J, Zhang J, Zhong J, Wang H, Xiong B
Theriogenology 2025 Apr 1;236:8-12

Effects of hyperhomocysteinemia on follicular development and oocytes quality.

Wang L, Gao J, Ma J, Sun J, Wang Y, Luo J, Wang Z, Wang H, Li J, Yang D, Wang J, Hu R
iScience 2024 Nov 15;27(11):111241

TENT5-mediated polyadenylation of mRNAs encoding secreted proteins is essential for gametogenesis in mice.

Brouze M, Czarnocka-Cieciura A, Gewartowska O, Kusio-Kobiałka M, Jachacy K, Szpila M, Tarkowski B, Gruchota J, Krawczyk P, Mroczek S, Borsuk E, Dziembowski A
Nature communications 2024 Jun 22;15(1):5331

Pre-pubertal obesity compromises ovarian oxidative stress, DNA repair and chemical biotransformation.

Timme K, González-Alvarez ME, Keating AF
Toxicology and applied pharmacology 2024 Aug;489:116981

Intracellular fraction of zona pellucida protein 3 is required for the oocyte-to-embryo transition in mice.

Israel S, Seyfarth J, Nolte T, Drexler HCA, Fuellen G, Boiani M
Molecular human reproduction 2023 Nov 1;29(11)

Circadian regulation of mTORC1 signaling via Per2 dependent mechanism disrupts folliculogenesis and oocyte maturation in female mice.

Bora G, Önel T, Yıldırım E, Yaba A
Journal of molecular histology 2023 Jun;54(3):217-229

Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice.

Zhang G, Jiang C, Yang Y, Wang Y, Zhou H, Dai S, Liu M, Yang Y, Yang L, Shen Q, Zhang T, Zhang X, Yang Y, Shen Y
Cell death and differentiation 2023 Feb;30(2):500-514

Hydroxychloroquine protects against autoimmune premature ovarian insufficiency by modulating the Treg/Th17 cell ratio in BALB/c mice.

Shuai L, She J, Diao R, Zhao H, Liu X, Hu Q, Li D, Su D, Ye X, Guo Y, Zhong M, Wang L
American journal of reproductive immunology (New York, N.Y. : 1989) 2023 Apr;89(4):e13686

A novel gene mutation in ZP3 loop region identified in patients with empty follicle syndrome.

Zhang Z, Guo Q, Jia L, Zhou C, He S, Fang C, Zhang M, Sun P, Zeng Z, Wang M, Wang D, Liang X
Human mutation 2022 Feb;43(2):180-188

Transglutaminase 2 crosslinks zona pellucida glycoprotein 3 to prevent polyspermy.

Cui Z, Lu Y, Miao Y, Dai X, Zhang Y, Xiong B
Cell death and differentiation 2022 Aug;29(8):1466-1473

Identification of a heterozygous variant of ZP2 as a novel cause of empty follicle syndrome in humans and mice.

Shen Y, Guo J, Zhang X, Wang X, Zhu S, Chen D, Xiong W, Lu G, Liu X, Dai C, Gong F, Wang Y, Lin G, Wang Z, Xu W
Human reproduction (Oxford, England) 2022 Apr 1;37(4):859-872

The critical role of ZP genes in female infertility characterized by empty follicle syndrome and oocyte degeneration.

Yang P, Chen T, Liu Y, Hou Z, Wu K, Cao Y, Zhang J, Wang Z, Zhao H
Fertility and sterility 2021 May;115(5):1259-1269

The inhibition of WIP1 phosphatase accelerates the depletion of primordial follicles.

Zhou S, Xi Y, Chen Y, Wu T, Yan W, Li M, Wu M, Luo A, Shen W, Xiang T, Wang S
Reproductive biomedicine online 2021 Aug;43(2):161-171

Pretreatment of ovaries with collagenase before vitrification keeps the ovarian reserve by maintaining cell-cell adhesion integrity in ovarian follicles.

Kawai T, Shimada M
Scientific reports 2020 Apr 22;10(1):6841

Ultrastructure and intercellular contact-mediated communication in cultured human early stage follicles exposed to mTORC1 inhibitor.

Grosbois J, Vermeersch M, Devos M, Clarke HJ, Demeestere I
Molecular human reproduction 2019 Nov 30;25(11):706-716

Abnormal gametogenesis induced by p53 deficiency promotes tumor progression and drug resistance.

Liu C, Cai Z, Jin G, Peng D, Pan BS, Zhang X, Han F, Xu X, Lin HK
Cell discovery 2018;4:54

A Recurrent Missense Mutation in ZP3 Causes Empty Follicle Syndrome and Female Infertility.

Chen T, Bian Y, Liu X, Zhao S, Wu K, Yan L, Li M, Yang Z, Liu H, Zhao H, Chen ZJ
American journal of human genetics 2017 Sep 7;101(3):459-465

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The ZP3 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human ZP3. This antibody recognizes human antigen. The ZP3 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
Appendix: 21279-1-AP.pdf

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human breast cancer using 21279-1-AP(ZP3 antibody) at dilution of 1:50 (under 40x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human breast cancer using 21279-1-AP(ZP3 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue