PABL-460

antibody from Creative Biolabs

Targeting: ECD GCR2, hSGT1

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

PABL-460

Provider

Creative Biolabs

Product name

Human Anti-ECD Recombinant Antibody (clone mAb23)

Antibody type

Monoclonal

Description

Recombinant Human Antibody (mAb23) is capable of binding to ECD, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-ECD mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-ECD proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody blocks glucagon binding and inhibits basal receptor activity, indicating that it is an inverse agonist and that the ECD can negatively regulate receptor activity independent of ligand binding.

Reactivity

Human

Host

Human

Antibody clone number

mAb23

Storage

Centrifuge briefly prior to opening vial. Store at +4¡ãC short term (1-2 weeks). Aliquot and store at -20¡ãC long term. Avoid repeated freeze/thaw cycles.