FNab10368

antibody from FineTest Biotech

Targeting: ECD GCR2, hSGT1

Western blot

ELISA

Immunohistochemistry

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Validation data

Product number: FNab10368 - Provider product page
Provider: FineTest Biotech
Product name: ECD antibody
Antibody type: Polyclonal
Antigen: Recombinant protein fragment
Description: Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP(PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes(PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins(PubMed:19640839). The cell cycle-regulating function may depend on its RUVBL1-mediated association with the R2TP complex(PubMed:26711270). May play a role in regulation of pre-mRNA splicing(PubMed:24722212).
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Antigen sequence: ecdysoneless homolog(Drosophila)
Epitope: IgG
Isotype: IgG
Vial size: 100¦Ìg
Concentration: Immunogen affinity purified
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)

ECD protein structure - FNab10368 shown in red.