BS60780

antibody from Bioworld Technology, Inc
Targeting: ADGRB3 BAI3, KIAA0550
Provider product page for BS60780

Antibody data

Product number
BS60780 - Provider product page
Provider
Bioworld Technology, Inc
Product name
BAI3 polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human BAI3
Description
Brain-specific angiogenesis inhibitors, including BAI-1, BAI-2, and BAI-3, are integral membrane proteins belonging to the G-protein coupled receptor 2 family. In addition to inhibiting angiogenesis in the brain, BAI proteins are also expressed in the heart, thymus, skeletal muscle, and a variety of cell lines. BAI-3 is predominantly expressed in brain. Reduced expression may be observed in some glioblastoma cell lines suggesting that BAI-3 may function in the suppression of glioblastoma. Localization of BAI-3 in most neurons of the cerebral cortex is analogous with BAI-1 and BAI-2 expression in the adult brain, but varies in the developing brain. The activity of brain-specific angiogenesis inhibitor proteins has been inversely correlated with vascularization in some cancer tissues. BAI-3 activity may be significant in the early phases of ishemia-induced brain angiogenesis and in brain tumor progression. A better understanding of the anti-angiogenic activity of these BAIs may offer potential therapeutic benefits.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
ADGRB3 protein structure - BS60780 shown in red.