Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS60780 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- BAI3 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to residues in Human BAI3
- Description
- Brain-specific angiogenesis inhibitors, including BAI-1, BAI-2, and BAI-3, are integral membrane proteins belonging to the G-protein coupled receptor 2 family. In addition to inhibiting angiogenesis in the brain, BAI proteins are also expressed in the heart, thymus, skeletal muscle, and a variety of cell lines. BAI-3 is predominantly expressed in brain. Reduced expression may be observed in some glioblastoma cell lines suggesting that BAI-3 may function in the suppression of glioblastoma. Localization of BAI-3 in most neurons of the cerebral cortex is analogous with BAI-1 and BAI-2 expression in the adult brain, but varies in the developing brain. The activity of brain-specific angiogenesis inhibitor proteins has been inversely correlated with vascularization in some cancer tissues. BAI-3 activity may be significant in the early phases of ishemia-induced brain angiogenesis and in brain tumor progression. A better understanding of the anti-angiogenic activity of these BAIs may offer potential therapeutic benefits.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of BAI3 pAb at 1:500 dilutionLane1:HEK293T whole cell lysateLane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate