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Learn15489-1-AP
antibody from Proteintech Group
Targeting: CPSF6
CFIM, CFIM68, CFIM72, HPBRII-4, HPBRII-7
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [18]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 15489-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15489-1-AP, RRID:AB_10694140
- Product name
- CPSF6 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CPSF6 antibody (Cat. #15489-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references CPSF6-mediated alternative polyadenylation of RUNX1 to regulate silica-induced pulmonary fibrosis progression.
SNW1 promotes lymphatic metastasis in bladder cancer by modulating SRPK1 splicing.
Alternative Polyadenylation Contributes to Fibroblast Senescence in Pulmonary Fibrosis.
NUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance.
CPSF6 promotes HIV-1 preintegration complex function.
Mediator regulates transcriptional termination through crosstalk with pre-mRNA 3' end processing factors.
CPSF6 loss mediates LDHA 3'UTR shortening to promote fibroblast glycolysis and pulmonary fibrosis.
IGF2BP3 recruits NUDT21 to regulate SPTBN1 alternative polyadenylation and drive ovarian cancer progression.
A new class of capsid-targeting inhibitors that specifically block HIV-1 nuclear import.
The polyA tail facilitates splicing of last introns with weak 3' splice sites via PABPN1.
Multi-omics approach reveals posttranscriptionally regulated genes are essential for human pluripotent stem cells.
NUDT21 Suppresses Breast Cancer Tumorigenesis Through Regulating CPSF6 Expression.
Cell Type-Dependent Escape of Capsid Inhibitors by Simian Immunodeficiency Virus SIVcpz.
A Quantitative Genetic Interaction Map of HIV Infection.
The HIV-1 capsid-binding host factor CPSF6 is post-transcriptionally regulated by the cellular microRNA miR-125b.
Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2.
Roles of Capsid-Interacting Host Factors in Multimodal Inhibition of HIV-1 by PF74.
In vivo functions of CPSF6 for HIV-1 as revealed by HIV-1 capsid evolution in HLA-B27-positive subjects.
Yang H, Zhang L, Han M, Wu Q, Zhang C, Xu Q
Respiratory research 2026 Jan 16;27(1):58
Respiratory research 2026 Jan 16;27(1):58
SNW1 promotes lymphatic metastasis in bladder cancer by modulating SRPK1 splicing.
Hu J, Zhu Y, Wang G, Dai H, Han H, Cao W, Ding M, Diao W, Lu Q, Zhang Q, Guo H, Chen W
iScience 2026 Feb 20;29(2):114811
iScience 2026 Feb 20;29(2):114811
Alternative Polyadenylation Contributes to Fibroblast Senescence in Pulmonary Fibrosis.
Huang J, Gacha-Garay MJ, Wang Y, Collum SD, Girard RA, Puente H, Yoo SH, Hussain R, Patel J, Patel M, Wagner EJ, KrishnaYalamanchili H, Karmouty-Quintana H, Chen Z, Mills T
Aging cell 2025 Oct;24(10):e70179
Aging cell 2025 Oct;24(10):e70179
NUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance.
Lin J, Yin Y, Cao J, Zhang Y, Chen J, Chen R, Zou B, Huang C, Lv Y, Xu S, Yang H, Lin P, Xie D
Cell discovery 2025 May 28;11(1):52
Cell discovery 2025 May 28;11(1):52
CPSF6 promotes HIV-1 preintegration complex function.
Chaudhuri E, Jang S, Chakraborty R, Radhakrishnan R, Arnarson B, Prakash P, Cornish D, Rohlfes N, Singh PK, Shi J, Aiken C, Campbell E, Hultquist J, Balsubramaniam M, Engelman AN, Dash C
Journal of virology 2025 May 20;99(5):e0049025
Journal of virology 2025 May 20;99(5):e0049025
Mediator regulates transcriptional termination through crosstalk with pre-mRNA 3' end processing factors.
Lu C, Bai X, Zhang H, Zhang Y, Yang M, Zheng Y, Jin Z, Yang W, Guo G, Huang Q, Huang Y, Wu L, Fu XD, Zhang Z, Wang G
Molecular cell 2025 Jun 5;85(11):2147-2164.e10
Molecular cell 2025 Jun 5;85(11):2147-2164.e10
CPSF6 loss mediates LDHA 3'UTR shortening to promote fibroblast glycolysis and pulmonary fibrosis.
Yang H, Han M, Zhang L, Yao C, Xu Q
Cellular signalling 2025 Dec;136:112165
Cellular signalling 2025 Dec;136:112165
IGF2BP3 recruits NUDT21 to regulate SPTBN1 alternative polyadenylation and drive ovarian cancer progression.
Luo X, Xie L, Ma X, Chen N, Xu J, Jiang X, Liu X, Yang Y, Liu T, Yi P, Xu J
Communications biology 2025 Apr 29;8(1):680
Communications biology 2025 Apr 29;8(1):680
A new class of capsid-targeting inhibitors that specifically block HIV-1 nuclear import.
Boulay A, Quevarec E, Malet I, Nicastro G, Chamontin C, Perrin S, Henriquet C, Pugnière M, Courgnaud V, Blaise M, Marcelin AG, Taylor IA, Chaloin L, Arhel NJ
EMBO molecular medicine 2024 Nov;16(11):2918-2945
EMBO molecular medicine 2024 Nov;16(11):2918-2945
The polyA tail facilitates splicing of last introns with weak 3' splice sites via PABPN1.
Huang L, Li G, Du C, Jia Y, Yang J, Fan W, Xu YZ, Cheng H, Zhou Y
EMBO reports 2023 Oct 9;24(10):e57128
EMBO reports 2023 Oct 9;24(10):e57128
Multi-omics approach reveals posttranscriptionally regulated genes are essential for human pluripotent stem cells.
Iwasaki M, Kawahara Y, Okubo C, Yamakawa T, Nakamura M, Tabata T, Nishi Y, Narita M, Ohta A, Saito H, Yamamoto T, Nakagawa M, Yamanaka S, Takahashi K
iScience 2022 May 20;25(5):104289
iScience 2022 May 20;25(5):104289
NUDT21 Suppresses Breast Cancer Tumorigenesis Through Regulating CPSF6 Expression.
Wang BJ, Liu DC, Guo QY, Han XW, Bi XM, Wang H, Wu ZS, Wu WY
Cancer management and research 2020;12:3069-3078
Cancer management and research 2020;12:3069-3078
Cell Type-Dependent Escape of Capsid Inhibitors by Simian Immunodeficiency Virus SIVcpz.
Twizerimana AP, Scheck R, Becker D, Zhang Z, Wammers M, Avelar L, Pflieger M, Häussinger D, Kurz T, Gohlke H, Münk C
Journal of virology 2020 Nov 9;94(23)
Journal of virology 2020 Nov 9;94(23)
A Quantitative Genetic Interaction Map of HIV Infection.
Gordon DE, Watson A, Roguev A, Zheng S, Jang GM, Kane J, Xu J, Guo JZ, Stevenson E, Swaney DL, Franks-Skiba K, Verschueren E, Shales M, Crosby DC, Frankel AD, Marson A, Marazzi I, Cagney G, Krogan NJ
Molecular cell 2020 Apr 16;78(2):197-209.e7
Molecular cell 2020 Apr 16;78(2):197-209.e7
The HIV-1 capsid-binding host factor CPSF6 is post-transcriptionally regulated by the cellular microRNA miR-125b.
Chaudhuri E, Dash S, Balasubramaniam M, Padron A, Holland J, Sowd GA, Villalta F, Engelman AN, Pandhare J, Dash C
The Journal of biological chemistry 2020 Apr 10;295(15):5081-5094
The Journal of biological chemistry 2020 Apr 10;295(15):5081-5094
Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2.
Kane M, Rebensburg SV, Takata MA, Zang TM, Yamashita M, Kvaratskhelia M, Bieniasz PD
eLife 2018 Aug 7;7
eLife 2018 Aug 7;7
Roles of Capsid-Interacting Host Factors in Multimodal Inhibition of HIV-1 by PF74.
Saito A, Ferhadian D, Sowd GA, Serrao E, Shi J, Halambage UD, Teng S, Soto J, Siddiqui MA, Engelman AN, Aiken C, Yamashita M
Journal of virology 2016 Jun 15;90(12):5808-5823
Journal of virology 2016 Jun 15;90(12):5808-5823
In vivo functions of CPSF6 for HIV-1 as revealed by HIV-1 capsid evolution in HLA-B27-positive subjects.
Henning MS, Dubose BN, Burse MJ, Aiken C, Yamashita M
PLoS pathogens 2014 Jan;10(1):e1003868
PLoS pathogens 2014 Jan;10(1):e1003868
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 15489-1-AP(CPSF6 antibody) at dilution of 1:100
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 15489-1-AP(CPSF6 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CPSF6 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CPSF6. This antibody recognizes human, mouse, rat antigen. The CPSF6 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
