WNK4

This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB. [provided by RefSeq, Sep 2009]

Description

WNK lysine deficient protein kinase 4

Tissue specificity

Tissue enhanced (esophagus, intestine, kidney, prostate)

Predicted location

Intracellular

Protein family

Disease related genes
Enzymes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

17 (42780610 - 42797066)

Ensembl ID

ENSG00000126562  (ver. 103.38)

Orthologs

Mouse Wnk4: ENSMUSG00000035112

UniProt

Q96J92

neXtProt

NX_Q96J92

Human splice variants
Mouse splice variants

Protein structure