Antibody data
- Antibody Data
- Antigen structure
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- Product number
- CABT-B9206 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Mouse anti-Rat Endothelin 1 Receptor monoclonal antibody, clone 27
- Antibody type
- Monoclonal
- Description
- Endothelin-1 (ET-1) is a potent vasoconstrictor that is secreted by vascular endothelial cells. ET-1, ET-2, ET-3, and endothelin ÉÇ are members of a family of related peptides. All are 21 amino acid peptides with two disulfide bridges. ET-1 and ET-2 differ by only two residues, while ET-3 differs from both by six residues. ET-1 and ET-2 are highly effective on vascular smooth muscle, while the effects of ET-3 are minimal. ET-1 and its precursor, big ET-1, are the primary forms present in the circulation. Circulating ET-1 plays a pathologic role in the etiology of hypertension and antagonists are utilized in the treatment of this disease. The ET-1 receptor is a seven-transmembrane-domain receptor of the G-protein-coupled family that signals via transient increases in intracellular Ca2+. It is primarily expressed in lung and heart and is detected at lower levels in liver, brain, muscle, and kidney. ET-1 receptor interacts with ET-1, ET-2, and ET-3. However, it has a 2-3 fold higher affinity for ET-1 than ET-2 and the affinity for ET-3 is more than 100 fold lower. Thus, ligation of the ET-1 receptor by ET-1 induces increased intracellular Ca2+ that signals to promote vasoconstriction.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 27
- Vial size
- 50 _g
- Concentration
- 250 Ã×g/ml
- Storage
- Store undiluted at -20°C.
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