22169-1-AP

antibody from Proteintech Group

Targeting: G6PC G6PC1, G6PT, GSD1a

Provider product page for 22169-1-AP

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [37]
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Product number: 22169-1-AP - Provider product page
Provider: Proteintech Group
Product name: G6PC antibody
Antibody type: Polyclonal
Description: G6PC antibody (Cat. #22169-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

G6PC protein structure - 22169-1-AP shown in red.

Submitted references Berberine directly targets AKR1B10 protein to modulate lipid and glucose metabolism disorders in NAFLD.

Yang S, Cao SJ, Li CY, Zhang Q, Zhang BL, Qiu F, Kang N
Journal of ethnopharmacology 2024 Oct 5;332:118354

TOX3 deficiency mitigates hyperglycemia by suppressing hepatic gluconeogenesis through FoxO1.

Liu C, Zheng Y, Hu S, Liang X, Li Y, Yu Z, Liu Y, Bian Y, Man Y, Zhao S, Liu X, Liu H, Huang T, Ma J, Chen ZJ, Zhao H, Zhang Y
Metabolism: clinical and experimental 2024 Mar;152:155766

Effect of Intracerebroventricular Administration of Galanin-Like Peptide on Hepatokines in C57BL/6 J Mice.

Hirako S, Wada N, Iizuka Y, Hirabayashi T, Kageyama H, Kim H, Kaibara N, Yanagisawa N, Takenoya F, Shioda S
Journal of molecular neuroscience : MN 2024 Feb 22;74(1):25

Metabolomic profiling reveals decreased serum cysteine levels during gestational diabetes mellitus progression.

Lai M, Li J, Yang J, Zhang Q, Gong Y, Ma Y, Fang F, Li N, Zhai Y, Shen T, Peng Y, Liu J, Wang Y
Journal of molecular cell biology 2024 Aug 26;16(3)

The FOXO1/G6PC axis promotes gastric cancer progression and mediates 5-fluorouracil resistance by targeting the PI3K/AKT/mTOR signaling pathway.

Han A, Liu T, Du P, Wang M, Liu J, Chen L
Molecular carcinogenesis 2024 Apr;63(4):688-700

Antidiabetic Effect of Collagen Peptides from Harpadon nehereus Bones in Streptozotocin-Induced Diabetes Mice by Regulating Oxidative Stress and Glucose Metabolism.

Lin Q, Guo Y, Li J, He S, Chen Y, Jin H
Marine drugs 2023 Sep 29;21(10)

Metabolic switch from glycogen to lipid in the liver maintains glucose homeostasis in neonatal mice.

Li L, Zhou H, Wang J, Li J, Lyu X, Wang W, Luo C, Huang H, Zhou D, Chen X, Xu L, Li P
Journal of lipid research 2023 Oct;64(10):100440

The Peptide AWRK6 Alleviates Lipid Accumulation in Hepatocytes by Inhibiting miR-5100 Targeting G6PC.

Liu J, Liu Y, Wang Q, Jin L, Zhang D
International journal of molecular sciences 2023 Nov 9;24(22)

Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein proximity networks link lipid modification and mitochondria.

Speck SL, Bhatt DP, Zhang Q, Adak S, Yin L, Dong G, Feng C, Zhang W, Ben Major M, Wei X, Semenkovich CF
Cell reports 2023 Nov 28;42(11):113389

Douchi Peptides VY and SFLLR Improve Glucose Homeostasis and Gut Dysbacteriosis in High-Fat Diet-Induced Insulin Resistant Mice.

Yu S, Wang W, Wang H, Bu T, Liu L, Zhao R, Li S, Liu D, Wu J
Molecular nutrition & food research 2023 May;67(10):e2200681

Transcriptional coactivation by EHMT2 restricts glucocorticoid-induced insulin resistance in a study with male mice.

Lee RA, Chang M, Yiv N, Tsay A, Tian S, Li D, Poulard C, Stallcup MR, Pufall MA, Wang JC
Nature communications 2023 May 30;14(1):3143

Aspirin Suppresses Hepatic Glucagon Signaling Through Decreasing Production of Thromboxane A2.

Dai Y, Xu R, Wu G, Yin Z, Zhang H, Li H, Chen W
Endocrinology 2023 Jan 9;164(3)

Loss of hepatic phosphoenolpyruvate carboxykinase 1 dysregulates metabolic responses to acute exercise but enhances adaptations to exercise training in mice.

Rome FI, Shobert GL, Voigt WC, Stagg DB, Puchalska P, Burgess SC, Crawford PA, Hughey CC
American journal of physiology. Endocrinology and metabolism 2023 Jan 1;324(1):E9-E23

Association of Aquaporin 7 and 9 with Obesity and Fatty Liver in db/db Mice.

Hirako S, Wakayama Y, Kim H, Iizuka Y, Wada N, Kaibara N, Okabe M, Arata S, Matsumoto A
Zoological science 2023 Dec;40(6):455-462

The 15-hydroxyprostaglandin dehydrogenase inhibitor SW033291 ameliorates abnormal hepatic glucose metabolism through PGE(2)-EP4 receptor-AKT signaling in a type 2 diabetes mellitus mouse model.

Liang M, Wang L, Wang W
Cellular signalling 2023 Aug;108:110707

Histone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting.

Zhao Y, Li S, Chen Y, Wang Y, Wei Y, Zhou T, Zhang Y, Yang Y, Chen L, Liu Y, Hu C, Zhou B, Ding Q
Molecular cell 2023 Apr 6;83(7):1093-1108.e8

G-protein coupled receptor 19 (GPR19) knockout mice display sex-dependent metabolic dysfunction.

Mushala BAS, Xie B, Sipula IJ, Stoner MW, Thapa D, Manning JR, Bugga P, Vandevender AM, Jurczak MJ, Scott I
Scientific reports 2023 Apr 15;13(1):6134

Paternal High-Fat Diet Altered Sperm 5'tsRNA-Gly-GCC Is Associated With Enhanced Gluconeogenesis in the Offspring.

Wang B, Xia L, Zhu D, Zeng H, Wei B, Lu L, Li W, Shi Y, Liu J, Zhang Y, Sun M
Frontiers in molecular biosciences 2022;9:857875

NFYA promotes the anti-tumor effects of gluconeogenesis in hepatocellular carcinoma through the regulation of PCK1 expression.

Tsujimoto G, Ito R, Yoshikawa K, Ueki C, Okada N
Frontiers in cell and developmental biology 2022;10:983599

20(S)-ginsenoside Rh1 alleviates T2DM induced liver injury via the Akt/FOXO1 pathway.

Su WY, Fan ML, Li Y, Hu JN, Cai EB, Zhu HY, Song MJ, Li W
Chinese journal of natural medicines 2022 Sep;20(9):669-678

Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction.

Rome FI, Hughey CC
Molecular metabolism 2022 Apr;58:101452

Functionalized gadofullerene ameliorates impaired glycolipid metabolism in type 2 diabetic mice.

Wu J, Chen Y, Li X, Ran L, Liu X, Wang X, Zhen M, Shao S, Zeng L, Wang C, Liang B, Zhao J, Wu Y
Journal of genetics and genomics = Yi chuan xue bao 2022 Apr;49(4):364-376

Comparative analysis of long non‑coding RNA expression profiles induced by resveratrol and metformin treatment for hepatic insulin resistance.

Shu L, Hou X, Song G, Wang C, Ma H
International journal of molecular medicine 2021 Nov;48(5)

Human umbilical cord-derived mesenchymal stem cell-exosomal miR-627-5p ameliorates non-alcoholic fatty liver disease by repressing FTO expression.

Cheng L, Yu P, Li F, Jiang X, Jiao X, Shen Y, Lai X
Human cell 2021 Nov;34(6):1697-1708

Exercise ameliorates insulin resistance and improves SIRT6-mediated insulin signaling transduction in liver of obese rats.

Zhang Y, Yang Z, Xu Z, Wan J, Hua T, Sun Q
Canadian journal of physiology and pharmacology 2021 May;99(5):506-511

Resveratrol Upregulates mmu-miR-363-3p via the PI3K-Akt Pathway to Improve Insulin Resistance Induced by a High-Fat Diet in Mice.

Shu L, Zhao H, Huang W, Hou G, Song G, Ma H
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:391-403

Long non-coding RNA expression profiling following treatment with resveratrol to improve insulin resistance.

Shu L, Hou G, Zhao H, Huang W, Song G, Ma H
Molecular medicine reports 2020 Aug;22(2):1303-1316

Resveratrol affects hepatic gluconeogenesis via histone deacetylase 4.

Zhao H, Shu L, Huang W, Song G, Ma H
Diabetes, metabolic syndrome and obesity : targets and therapy 2019;12:401-411

Micro-RNA-27a/b negatively regulates hepatic gluconeogenesis by targeting FOXO1.

Wang S, Ai H, Liu L, Zhang X, Gao F, Zheng L, Yi J, Sun L, Yu C, Zhao H, Li Y
American journal of physiology. Endocrinology and metabolism 2019 Nov 1;317(5):E911-E924

Vaccarin ameliorates insulin resistance and steatosis by activating the AMPK signaling pathway.

Lei Y, Gong L, Tan F, Liu Y, Li S, Shen H, Zhu M, Cai W, Xu F, Hou B, Zhou Y, Han H, Qiu L, Sun H
European journal of pharmacology 2019 May 15;851:13-24

The NQO1/PKLR axis promotes lymph node metastasis and breast cancer progression by modulating glycolytic reprogramming.

Yang Y, Zhu G, Dong B, Piao J, Chen L, Lin Z
Cancer letters 2019 Jul 1;453:170-183

Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells.

Wang F, Chang C, Li R, Zhang Z, Jiang H, Zeng N, Li D, Chen L, Xiao Y, Chen W, Wang Q
Toxicology 2019 Aug 1;424:152236

Adropin reduces blood glucose levels in mice by limiting hepatic glucose production.

Thapa D, Xie B, Manning JR, Zhang M, Stoner MW, Huckestein BR, Edmunds LR, Zhang X, Dedousis NL, O'Doherty RM, Jurczak MJ, Scott I
Physiological reports 2019 Apr;7(8):e14043

Effects of calycosin against high-fat diet-induced nonalcoholic fatty liver disease in mice.

Duan X, Meng Q, Wang C, Liu Z, Sun H, Huo X, Sun P, Ma X, Peng J, Liu K
Journal of gastroenterology and hepatology 2018 Feb;33(2):533-542

Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway.

Yan J, Wang C, Jin Y, Meng Q, Liu Q, Liu Z, Liu K, Sun H
Pharmacological research 2018 Apr;130:466-480

Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis.

Jiang L, Xiong J, Zhan J, Yuan F, Tang M, Zhang C, Cao Z, Chen Y, Lu X, Li Y, Wang H, Wang L, Wang J, Zhu WG, Wang H
The Journal of biological chemistry 2017 Aug 11;292(32):13296-13311

1,2-Dichloroethane impairs glucose and lipid homeostasis in the livers of NIH Swiss mice.

Wang T, Xu D, Fan Q, Rong W, Zheng J, Gao C, Li G, Zeng N, Guo T, Zeng L, Wang F, Xiao C, Cai L, Tang S, Deng X, Yin X, Huang M, Lu F, Hu Q, Chen W, Huang Z, Wang Q
Toxicology 2017 Apr 1;380:38-49

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