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- Antigen structure
- References [10]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 14751-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14751-1-AP, RRID:AB_2156092
- Product name
- OSBPL2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated OSBPL2 antibody (Cat. #14751-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references ORP8 acts as a lipophagy receptor to mediate lipid droplet turnover.
Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.
OSBPL2 mutations impair autophagy and lead to hearing loss, potentially remedied by rapamycin.
Mutations in OSBPL2 cause hearing loss associated with primary cilia defects via sonic hedgehog signaling.
New label-free methods for protein relative quantification applied to the investigation of an animal model of Huntington Disease.
OSBPL2 deficiency upregulate SQLE expression increasing intracellular cholesterol and cholesteryl ester by AMPK/SP1 and SREBF2 signalling pathway.
Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P(2) That Regulates Neuronal Excitability.
ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P(2)).
Oxysterol-related-binding-protein related Protein-2 (ORP2) regulates cortisol biosynthesis and cholesterol homeostasis.
Identification of OSBPL2 as a novel candidate gene for progressive nonsyndromic hearing loss by whole-exome sequencing.
Pu M, Zheng W, Zhang H, Wan W, Peng C, Chen X, Liu X, Xu Z, Zhou T, Sun Q, Neculai D, Liu W
Protein & cell 2023 Sep 14;14(9):653-667
Protein & cell 2023 Sep 14;14(9):653-667
Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.
Kiss RS, Chicoine J, Khalil Y, Sladek R, Chen H, Pisaturo A, Martin C, Dale JD, Brudenell TA, Kamath A, Kyei-Boahen J, Hafiane A, Daliah G, Alecki C, Hopes TS, Heier M, Aligianis IA, Lebrun JJ, Aspden J, Paci E, Kerksiek A, Lütjohann D, Clayton P, Wills JC, von Kriegsheim A, Nilsson T, Sheridan E, Handley MT
The Journal of biological chemistry 2023 Nov;299(11):105295
The Journal of biological chemistry 2023 Nov;299(11):105295
OSBPL2 mutations impair autophagy and lead to hearing loss, potentially remedied by rapamycin.
Koh YI, Oh KS, Kim JA, Noh B, Choi HJ, Joo SY, Rim JH, Kim HY, Kim DY, Yu S, Kim DH, Lee SG, Jung J, Choi JY, Gee HY
Autophagy 2022 Nov;18(11):2593-2614
Autophagy 2022 Nov;18(11):2593-2614
Mutations in OSBPL2 cause hearing loss associated with primary cilia defects via sonic hedgehog signaling.
Shi H, Wang H, Zhang C, Lu Y, Yao J, Chen Z, Xing G, Wei Q, Cao X
JCI insight 2022 Feb 22;7(4)
JCI insight 2022 Feb 22;7(4)
New label-free methods for protein relative quantification applied to the investigation of an animal model of Huntington Disease.
Cozzolino F, Landolfi A, Iacobucci I, Monaco V, Caterino M, Celentano S, Zuccato C, Cattaneo E, Monti M
PloS one 2020;15(9):e0238037
PloS one 2020;15(9):e0238037
OSBPL2 deficiency upregulate SQLE expression increasing intracellular cholesterol and cholesteryl ester by AMPK/SP1 and SREBF2 signalling pathway.
Zhang C, Zhang H, Zhang M, Lin C, Wang H, Yao J, Wei Q, Lu Y, Chen Z, Xing G, Cao X
Experimental cell research 2019 Oct 15;383(2):111512
Experimental cell research 2019 Oct 15;383(2):111512
Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P(2) That Regulates Neuronal Excitability.
Vivas O, Tiscione SA, Dixon RE, Ory DS, Dickson EJ
Cell reports 2019 May 28;27(9):2636-2648.e4
Cell reports 2019 May 28;27(9):2636-2648.e4
ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P(2)).
Wang H, Ma Q, Qi Y, Dong J, Du X, Rae J, Wang J, Wu WF, Brown AJ, Parton RG, Wu JW, Yang H
Molecular cell 2019 Feb 7;73(3):458-473.e7
Molecular cell 2019 Feb 7;73(3):458-473.e7
Oxysterol-related-binding-protein related Protein-2 (ORP2) regulates cortisol biosynthesis and cholesterol homeostasis.
Escajadillo T, Wang H, Li L, Li D, Sewer MB
Molecular and cellular endocrinology 2016 May 15;427:73-85
Molecular and cellular endocrinology 2016 May 15;427:73-85
Identification of OSBPL2 as a novel candidate gene for progressive nonsyndromic hearing loss by whole-exome sequencing.
Xing G, Yao J, Wu B, Liu T, Wei Q, Liu C, Lu Y, Chen Z, Zheng H, Yang X, Cao X
Genetics in medicine : official journal of the American College of Medical Genetics 2015 Mar;17(3):210-8
Genetics in medicine : official journal of the American College of Medical Genetics 2015 Mar;17(3):210-8
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 14751-1-AP(OSBPL2 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The OSBPL2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human OSBPL2. This antibody recognizes human, mouse, rat antigen. The OSBPL2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
