55407-1-AP

antibody from Proteintech Group

Targeting: KIF15 HKLP2, KNSL7, NY-BR-62

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

55407-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#55407-1-AP, RRID:AB_11182836

Product name

KIF15 antibody

Antibody type

Polyclonal

Description

KD/KO validated KIF15 antibody (Cat. #55407-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Kif15 Orchestrates Neuronal-Microglial Communication via CX3CL1 to Impede Nerve Regeneration.

Wu R, Zhang W, Qian X, Dong Z, He X, Zhang S, Chen T, Yang L, Liu Y, Liu M
The Journal of biological chemistry 2026 Apr 27;:113090

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KIF18A promotes chromosome congression in cooperation with CENP-E downstream of CENP-C.

Miao J, Hara M, Su KC, Keys HR, Kong W, Takenoshita Y, Cheeseman IM, Fukagawa T
Cell reports 2025 Nov 25;44(11):116515

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Deficiency of KIF15 contributes to oxaliplatin-induced cold hypersensitivity by limiting annexin A2 and enhancing TRPA1 localization in DRG neuronal membrane.

Wu LY, Zhai MN, Bai XQ, He C, Guo YY, Zhang YQ, Wang J, Gao YT, Tu QF, Liu M, Chen JJ, Zhang ZJ
Neuropharmacology 2025 May 15;269:110343

---

Integrative network and computational toxicology reveal the molecular mechanisms in PFOA-induced spermatogenic disorder.

Luo Y, Xue E, Zhao Y, Lu H, Xiang D, Zhou Y, Zhan J, Li Z, Sun F
Journal of environmental management 2025 Jun;386:125754

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PCP protein Prickle 1 regulates Sertoli cell and testis function via cytoskeletal organization through the recruitment of multiple regulatory proteins.

Wang L, Bu T, Gao S, Yun D, Chen H, Cheng CY, Sun F
American journal of physiology. Cell physiology 2025 Jun 1;328(6):C2032-C2056

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METTL3 methylated KIF15 promotes nasopharyngeal carcinoma progression and radiation resistance by blocking ATG7-mediated autophagy through the activation of STAT3 pathway.

Li S, Wang S, Zhang L, Wu X, Tian L, Zou J, Pi G
Translational oncology 2025 Jan;51:102161

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Inhibition of the FEN1-PBX1 axis elicits cellular senescence in breast cancer via the increased intracellular reactive oxygen species levels.

Wu M, Wu B, Huang X, Wang Z, Zhu M, Zhu Y, Yu L, Liu J
Journal of translational medicine 2025 Feb 28;23(1):248

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KIF15 promotes human glioblastoma progression under the synergistic transactivation of REST and P300.

Yu W, Han S, Hu S, Ru L, Hua C, Xue G, Zhang G, Lv K, Ge H, Wang M, Zheng L, Zhou J, Hou S, Teng Y, Deng W, Guo W
International journal of biological sciences 2024;20(13):5127-5144

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Integrated machine learning algorithms identify KIF15 as a potential prognostic biomarker and correlated with stemness in triple-negative breast cancer.

Guo Q, Qiu P, Pan K, Liang H, Liu Z, Lin J
Scientific reports 2024 Sep 13;14(1):21449

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Polystyrene nanoplastics accelerate atherosclerosis: Unraveling the impact on smooth muscle cells through KIF15-mediated migration.

Zhong Y, Feng Y, Huang Y, Wang B, Shi W, Liang B, Li Z, Zhang B, Du J, Xiu J, Yang X, Huang Z
Ecotoxicology and environmental safety 2024 Oct 1;284:116983

---

Map-1a regulates Sertoli cell BTB dynamics through the cytoskeletal organization of microtubule and F-actin.

Wang L, Yan M, Bu T, Wu X, Li L, Silvestrini B, Sun F, Cheng CY, Chen H
Reproductive biology and endocrinology : RB&E 2024 Apr 3;22(1):36

---

The mitotic spindle-related seven-gene predicts the prognosis and immune microenvironment of lung adenocarcinoma.

Shen R, Li Z, Wu X
Journal of cancer research and clinical oncology 2023 Sep;149(12):10131-10141

---

Inducing Mitotic Catastrophe as a Therapeutic Approach to Improve Outcomes in Ewing Sarcoma.

Turaga SM, Vishwakarma V, Hembruff SL, Gibbs BK, Sabu P, Puri RV, Pathak HB, Samuel G, Godwin AK
Cancers 2023 Oct 10;15(20)

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Polyamine metabolism patterns characterized tumor microenvironment, prognosis, and response to immunotherapy in colorectal cancer.

Zhang E, Ding C, Li S, Aikemu B, Zhou X, Fan X, Sun J, Yang X, Zheng M
Cancer cell international 2023 May 18;23(1):96

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Kif15 Is Required in the Development of Auditory System Using Zebrafish as a Model.

Zheng S, Tang D, Wang X, Liu C, Zuo N, Yan R, Wu C, Ma J, Wang C, Xu H, He Y, Liu D, Liu S
Frontiers in molecular neuroscience 2022;15:844568

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Transcriptional, Post-Transcriptional, and Post-Translational Mechanisms Rewrite the Tubulin Code During Cardiac Hypertrophy and Failure.

Phyo SA, Uchida K, Chen CY, Caporizzo MA, Bedi K, Griffin J, Margulies K, Prosser BL
Frontiers in cell and developmental biology 2022;10:837486

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Rare and Common Variants in KIF15 Contribute to Genetic Risk of Idiopathic Pulmonary Fibrosis.

Zhang D, Povysil G, Kobeissy PH, Li Q, Wang B, Amelotte M, Jaouadi H, Newton CA, Maher TM, Molyneaux PL, Noth I, Martinez FJ, Raghu G, Todd JL, Palmer SM, Haefliger C, Platt A, Petrovski S, Garcia JA, Goldstein DB, Garcia CK
American journal of respiratory and critical care medicine 2022 Jul 1;206(1):56-69

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PSMD12 promotes the activation of the MEK-ERK pathway by upregulating KIF15 to promote the malignant progression of liver cancer.

Zhang H, Li C, Liao S, Tu Y, Sun S, Yao F, Li Z, Wang Z
Cancer biology & therapy 2022 Dec 31;23(1):1-11

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KIF15 Promotes Progression of Castration Resistant Prostate Cancer by Activating EGFR Signaling Pathway.

Gao L, Zhao R, Liu J, Zhang W, Sun F, Yin Q, Wang X, Wang M, Feng T, Qin Y, Cai W, Li Q, Dong H, Chen X, Xiong X, Liu H, Hu J, Chen W, Han B
Frontiers in oncology 2021;11:679173

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KIF15 upregulation promotes leiomyosarcoma cell growth via promoting USP15-mediated DEK deubiquitylation.

Ge W, Chen Y, Guo Y, Zhao D, Mu L, Zhang K, Zhuo W
Biochemical and biophysical research communications 2021 Sep 17;570:117-124

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Kinesin 12 (KIF15) contributes to the development and tumorigenicity of prostate cancer.

Qureshi Z, Ahmad M, Yang WX, Tan FQ
Biochemical and biophysical research communications 2021 Oct 22;576:7-14

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HIV-1 Establishes a Sanctuary Site in the Testis by Permeating the BTB Through Changes in Cytoskeletal Organization.

Wu S, Frank I, Derby N, Martinelli E, Cheng CY
Endocrinology 2021 Nov 1;162(11)

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KIF15-Mediated Stabilization of AR and AR-V7 Contributes to Enzalutamide Resistance in Prostate Cancer.

Gao L, Zhang W, Zhang J, Liu J, Sun F, Liu H, Hu J, Wang X, Wang X, Su P, Chen S, Qu S, Shi B, Xiong X, Chen W, Dong X, Han B
Cancer research 2021 Feb 15;81(4):1026-1039

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KIF15 supports spermatogenesis via its effects on Sertoli cell microtubule, actin, vimentin, and septin cytoskeletons.

Wu S, Lv L, Li L, Wang L, Mao B, Li J, Shen X, Ge R, Wong CKC, Sun F, Cheng CY
Endocrinology 2021 Apr 1;162(4)

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ZNF367-induced transcriptional activation of KIF15 accelerates the progression of breast cancer.

Zeng H, Li T, Zhai D, Bi J, Kuang X, Lu S, Shan Z, Lin Y
International journal of biological sciences 2020;16(12):2084-2093

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KIF15 contributes to cell proliferation and migration in breast cancer.

Gao X, Zhu L, Lu X, Wang Y, Li R, Jiang G
Human cell 2020 Oct;33(4):1218-1228

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B7-H3 regulates KIF15-activated ERK1/2 pathway and contributes to radioresistance in colorectal cancer.

Ma Y, Zhan S, Lu H, Wang R, Xu Y, Zhang G, Cao L, Shi T, Zhang X, Chen W
Cell death & disease 2020 Oct 3;11(10):824

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KIF11 and KIF15 mitotic kinesins are potential therapeutic vulnerabilities for malignant peripheral nerve sheath tumors.

Terribas E, Fernández M, Mazuelas H, Fernández-Rodríguez J, Biayna J, Blanco I, Bernal G, Ramos-Oliver I, Thomas C, Guha R, Zhang X, Gel B, Romagosa C, Ferrer M, Lázaro C, Serra E
Neuro-oncology advances 2020 Jul;2(Suppl 1):i62-i74

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KIF15 promotes bladder cancer proliferation via the MEK-ERK signaling pathway.

Zhao H, Bo Q, Wu Z, Liu Q, Li Y, Zhang N, Guo H, Shi B
Cancer management and research 2019;11:1857-1868

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KIF15 plays a role in promoting the tumorigenicity of melanoma.

Yu X, He X, Heindl LM, Song X, Fan J, Jia R
Experimental eye research 2019 Aug;185:107598

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Increased KIF15 Expression Predicts a Poor Prognosis in Patients with Lung Adenocarcinoma.

Qiao Y, Chen J, Ma C, Liu Y, Li P, Wang Y, Hou L, Liu Z
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;51(1):1-10

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Involvement of C-terminal truncation mutation of kinesin-5 in resistance to kinesin-5 inhibitor.

Saeki E, Yasuhira S, Shibazaki M, Tada H, Doita M, Masuda T, Maesawa C
PloS one 2018;13(12):e0209296

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

mouse thymus tissue were subjected to SDS PAGE followed by western blot with 55407-1-AP(KIF15 antibody) at dilution of 1:500

Sample type

tissue

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human testis using 55407-1-AP(KIF15 antibody) at dilution of 1:50 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The KIF15 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human KIF15. This antibody recognizes human, mouse, rat antigen. The KIF15 antibody has been validated for the following applications: ELISA, WB, IHC analysis.

Appendix

55407-1-AP.pdf

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