20080-1-AP

antibody from Proteintech Group

Targeting: MAS1L dJ994E9.2, MAS-L, MRG

Provider product page for 20080-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [26]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 20080-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#20080-1-AP, RRID:AB_10665372
Product name: MAS1L-Specific antibody
Antibody type: Polyclonal
Description: MAS1L-Specific antibody (Cat. #20080-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

MAS1L protein structure - 20080-1-AP shown in red.

Submitted references Angiotensin-(1-7) alleviates intestinal barrier dysfunction and dysbiosis in mice with polymicrobial sepsis.

Wang J, Li J, Li Y, Huang W, Huang C, Xu Q, Sun J, Gong J, Ma X, Wang G, Meng Y, Li X
British journal of pharmacology 2026 May;183(9):2028-2048

Angiotensin-(1-7) Inhibits Angiogenesis and Alleviates Joint Damage in CIA Mice via the Hippo-YAP Pathway.

Zhang S, Sheng M, Yu D, Qian K, Zhang Y, Huang W, Ren F, Tang L
Journal of inflammation research 2025;18:12401-12419

SERCA2 dysfunction accelerates angiotensin II-induced aortic aneurysm and atherosclerosis by induction of oxidative stress in aortic smooth muscle cells.

Wang L, Song J, Yang Z, Zhang H, Wang Y, Liu J, Wang S, Shi J, Tong X
Journal of molecular and cellular cardiology 2025 Mar;200:68-81

A peptide from Boletus griseus-Hypomyces chrysospermus protects against hypertension and associated cardiac and renal damage through modulating RAAS and intestinal microbiota.

Huan P, Sun L, Chen S, Zhong Y, Zhuang Y
Journal of food science 2025 Jan;90(1):e17617

Walnut peptide relieves hypertension and associated kidney and heart injury by regulating the renin-angiotensin-aldosterone system and intestinal microbiota.

Chen S, Huan P, Ma T, Zhong Y, Ning D, Zhuang Y
Journal of the science of food and agriculture 2025 Jan 30;105(2):1170-1184

Differential Mechanisms of Soybean-Derived ACE2-Activating Peptides IVPQ and IAVPT in ACE2-Mediated Endothelial Protection.

Zhou M, Song T, Huang M, Zheng L, Zhao M
Journal of agricultural and food chemistry 2025 Feb 19;73(7):4065-4077

Repetitive transcranial magnetic stimulation ameliorates myocardial injury in vascular dementia via renin-angiotensin system modulation.

Li J, Su J, Zhu B, Gao X
Neuroreport 2025 Dec 10;36(18):1072-1080

ACE2 alleviates sepsis-induced cardiomyopathy through inhibiting M1 macrophage via NF-κB/STAT1 signals.

Xiao X, Li JX, Li HH, Teng F
Cell biology and toxicology 2024 Sep 25;40(1):82

GTS-21 attenuates ACE/ACE2 ratio and glycocalyx shedding in lipopolysaccharide-induced acute lung injury by targeting macrophage polarization derived ADAM-17.

Zhu W, Wang F, Hu C, Zhao Q, Zhang D, Wang X, Hu B, Li J
International immunopharmacology 2024 Mar 10;129:111603

ACE2 Expressed on Myeloid Cells Alleviates Sepsis-Induced Acute Liver Injury via the Ang-(1-7)-Mas Receptor Axis.

Liu L, Li Y, Li JX, Xiao X, Wan TT, Li HH, Guo SB
Inflammation 2024 Jun;47(3):891-908

Panax notoginseng saponin alleviates pulmonary fibrosis in rats by modulating the renin-angiotensin system.

Li H, Wang YG, Chen TF, Gao YH, Song L, Yang YF, Gao Y, Huo W, Zhang GP
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):116979

ACE2 activation alleviates sepsis-induced cardiomyopathy by promoting MasR-Sirt1-mediated mitochondrial biogenesis.

Wan TT, Li Y, Li JX, Xiao X, Liu L, Li HH, Guo SB
Archives of biochemistry and biophysics 2024 Feb;752:109855

Myeloid ACE2 protects against septic hypotension and vascular dysfunction through Ang-(1-7)-Mas-mediated macrophage polarization.

Li JX, Xiao X, Teng F, Li HH
Redox biology 2024 Feb;69:103004

ACE2 improves endothelial cell function and reduces acute lung injury by downregulating FAK expression.

He Y, Gang B, Zhang M, Bai Y, Wan Z, Pan J, Liu J, Liu G, Gu W
International immunopharmacology 2024 Feb 15;128:111535

α-Mangostin Attenuates Blood Pressure and Reverses Vascular Remodeling by Balancing ACE/AT1R and ACE2/Ang-(1-7)/MasR Axes in Ang II-Infused Hypertensive Mice.

Xue QQ, Liu CH, Zhang DY, Li MX, Li Y
Phytotherapy research : PTR 2024 Dec;38(12):5918-5929

The role of ACE2 in RAS axis on microglia activation in Parkinson's disease.

Liu T, Li J, Sun L, Zhu C, Wei J
Neuroscience 2024 Aug 16;553:128-144

miR-145 Alleviates Smooth Muscle Cell Phenotype Transition via ADAM17-Mediated ACE2 Shedding.

Wen J, Tang B, Guo L, Chen W, Tang X
International journal of hypertension 2023;2023:9497716

Canagliflozin Ameliorates Ventricular Remodeling through Apelin/Angiotensin-Converting Enzyme 2 Signaling in Heart Failure with Preserved Ejection Fraction Rats.

Zhang T, Wang X, Wang Z, Zhai J, He L, Wang Y, Zuo Q, Ma S, Zhang G, Guo Y
Pharmacology 2023;108(5):478-491

Azelaic Acid Regulates the Renin-Angiotensin System and Improves Colitis Based on Network Pharmacology and Experimentation.

Liao Y, Wu X, Luo W, Chen J, Huang Y, Ma K, Zhang C, Wang J, Yang Y, Deng M, Wang X
ACS omega 2023 May 2;8(17):15217-15228

The ACE2 activator diminazene aceturate ameliorates colitis by repairing the gut-vascular barrier in mice.

Zhang C, Cao X, Wang H, Li Z, Zhang Y
Microvascular research 2023 Jul;148:104544

ApoE4 associated with severe COVID-19 outcomes via downregulation of ACE2 and imbalanced RAS pathway.

Chen F, Chen Y, Ke Q, Wang Y, Gong Z, Chen X, Cai Y, Li S, Sun Y, Peng X, Ji Y, Zhang T, Wu W, Cui L, Wang Y
Journal of translational medicine 2023 Feb 9;21(1):103

Ang-(1-7)/MasR axis promotes functional recovery after spinal cord injury by regulating microglia/macrophage polarization.

Gu G, Zhu B, Ren J, Song X, Fan B, Ding H, Shang J, Wu H, Li J, Wang H, Li J, Wei Z, Feng S
Cell & bioscience 2023 Feb 4;13(1):23

Synergistic effect of constituent drugs of Baibutang on improving Yin-deficiency pulmonary fibrosis in rats.

Fu S, Song X, Tang X, Qian X, Du Z, Hu Y, Xu X, Zhang M
Journal of ethnopharmacology 2023 Apr 24;306:116050

The Pretreatment of Xiaoqinglong Decoction Alleviates Inflammation and Oxidative Damage and Up-Regulates Angiotensin-Converting Enzyme 2 in Lipopolysaccharide-Induced Septic Acute Lung Injury Rats.

Su JC, Cheng C, Wang CY, Zhang Y, He YT, Guo ZW, Liu XY, Liu WM, Zhang YJ, Xu SW, Zhang XY, Liu ZB, Zhang XF
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2421198

The ACE2-Ang-(1‑7)-Mas Axis Modulates M1/M2 Macrophage Polarization to Relieve CLP-Induced Inflammation via TLR4-Mediated NF-кb and MAPK Pathways.

Pan H, Huang W, Wang Z, Ren F, Luo L, Zhou J, Tian M, Tang L
Journal of inflammation research 2021;14:2045-2060

Electroacupuncture Improved Chronic Cerebral Hypoperfusion-Induced Anxiety-Like Behavior and Memory Impairments in Spontaneously Hypertensive Rats by Downregulating the ACE/Ang II/AT1R Axis and Upregulating the ACE2/Ang-(1-7)/MasR Axis.

Feng P, Wu Z, Liu H, Shen Y, Yao X, Li X, Shen Z
Neural plasticity 2020;2020:9076042

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HEK-293 cells were subjected to SDS PAGE followed by western blot with 20080-1-AP(MAS1L-Specific antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using MAS1L antibody 20080-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line