12666-2-AP

antibody from Proteintech Group

Targeting: CAMK2G CAMKG

Provider product page for 12666-2-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [40]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [1]

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Product number: 12666-2-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#12666-2-AP, RRID:AB_2068213
Product name: CaMKII Gamma antibody
Antibody type: Polyclonal
Description: KD/KO validated CaMKII Gamma antibody (Cat. #12666-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CAMK2G protein structure - 12666-2-AP shown in red.

Submitted references In Situ Reprogramming of Senescent Microenvironment via Augmentation of Endogenous Senolytic Actions for Advanced Atherosclerosis Management.

Wang Z, Chen X, Xu Y, Guo X, Liu X, Dai X, Lu J, Qi J, Zheng T, Zhang L, Ma L, Wang S, Yang G, Lu G, Wang F, Zhou Q, Sheng J, Zhang L
ACS nano 2026 Jan 13;20(1):1249-1266

Nonthermal radiofrequency radiation promotes hematopoietic stem and progenitor cells function by regulating Ca(2+) efflux.

Lv Z, Zhao K, Li J, Li S, Zhao X, Xu A, Wu Y, Gao H, Li J, Sun H, Xue Y, Li S, Xiang S, Yang X, Li C
Stem cell research & therapy 2026 Feb 14;17(1)

Zhao K, Hua D, Mao Y, Wu X, Gao M, Song S, Chen L, Zheng X, Li P
MedComm 2026 Apr;7(4):e70706

CaMKII nucleates an osmotic protein supercomplex to induce cellular bleb expansion.

Fujii Y, Sakai Y, Matsuzawa K, Ikenouchi J
The EMBO journal 2026 Apr;45(8):2433-2455

Mechanical stretch-mediated fibroblast activation: The pivotal role of Piezo1 channels.

Tu S, Li Y, Li J, Ma N, Yao K, Chen Z, Fan Z, Xu Z, Sa Y, Jia P, Lin X, Wang S, Fang Y, Liu Y, Guo Y
Biochimica et biophysica acta. Molecular cell research 2025 Oct;1872(7):120008

Bioelectrically Reprogramming Hydrogels Rejuvenate Vascularized Bone Regeneration in Senescence.

Wu T, Ren M, Li Y, Yang Q, Xiang K, Liu F, Yang S
Advanced healthcare materials 2025 Mar;14(6):e2403837

Identification of TRAF2, CAMK2G, and TIMM17A as biomarkers distinguishing mechanical asphyxia from sudden cardiac death base on 4D-DIA Proteomics: A pilot study.

Huang Y, Qiu H, Chen W, Meng Z, Cai Y, Qiao D, Yue X
Journal of pharmaceutical and biomedical analysis 2025 Jun 15;258:116730

Silver Needle Thermal Therapy Improves Mitochondrial Injury in the Skeletal Muscle of MPS Rats by Inhibiting the TRPV1/CaMKII Pathway.

Huang Y, An S, Tang Y, Yang X, Shen C, Huang Y, Wang L, Wo C
Physiological research 2025 Jul 23;74(3):481-492

A new specific GluN2B partial antagonist ameliorates brain injury caused by ischemic stroke in rats.

Fan Y, Wu H, Yin D, Liu Q, Yuan C, Zhong T, Xia B, Xiong L, Li Y, Zeng L, Li Y, Li Y, Tang L
Bioorganic chemistry 2025 Jul 1;161:108547

CARD11-BCL10-MALT1 Complex-Dependent MALT1 Activation Facilitates Myocardial Oxidative Stress in Doxorubicin-Treated Mice via Enhancing k48-Linked Ubiquitination of Nrf2.

Lu LQ, Li MR, Liu XY, Peng D, Liu HR, Zhang XJ, Luo XJ, Peng J
Antioxidants & redox signaling 2025 Jan;42(1-3):115-132

CAMK2G Promotes Neuronal Differentiation and Inhibits Migration in Neuroblastoma.

Ma Y, He C, Lin W, Wang J, Xu C, Pan D, Wang Z, Yao W, Dong R, Jia D, Li K
Journal of pediatric surgery 2025 Feb;60(2):161679

Mechanism of action of l-theanine on cerebellar granule cell migration via signaling pathways.

Ibrahim M, Kuriya K, Umekawa H, Nishio M
Bioscience, biotechnology, and biochemistry 2025 Dec 18;90(1):88-98

HOCPCA Exerts Neuroprotection on Retinal Ganglion Cells by Binding to CaMKIIα and Modulating Oxidative Stress and Neuroinflammation in Experimental Glaucoma.

Li P, Shi X, Liu H, Feng Y, Wang X, Herb M, Ji H, Wagner S, Vogt J, Prokosch V
Neuroscience bulletin 2025 Aug;41(8):1329-1346

Kilohertz High-Frequency Electrical Stimulation Effectively Mitigates Hyperalgesia in Mice With Neuropathic Pain Through Regulation of the Calcium/Calmodulin-Dependent Protein Kinase II/N-Methyl-D-Aspartate 2B Signaling Pathway.

Fang K, Ouyang X, Cheng W, Yu B
Neuromodulation : journal of the International Neuromodulation Society 2025 Aug;28(6):962-975

TAK-242 alleviates diabetic cardiomyopathy via inhibiting pyroptosis and TLR4/CaMKII/NLRP3 pathway.

Zhao X, Zhang J, Xu F, Shang L, Liu Q, Shen C
Open life sciences 2024;19(1):20220957

The phosphorylation of Smad3 by CaMKIIγ leads to the hepatocyte pyroptosis under perfluorooctane sulfonate exposure.

Ren S, Liang P, Feng R, Yang W, Qiu T, Zhang J, Li Q, Yang G, Sun X, Yao X
Ecotoxicology and environmental safety 2024 Oct 1;284:116924

The Effects of Different Developmental Stages on Bone Regeneration of Periodontal Ligament Stem Cells and Periodontal Ligament Cell Sheets In Vitro and Vivo.

Shao X, Wu F, Song Y, Kong R, Wang S, Wang L
Stem cells and development 2024 Nov;33(21-22):595-606

CaMKII protein expression and phosphorylation in human skeletal muscle by immunoblotting: Isoform specificity.

Martinez-Canton M, Gallego-Selles A, Galvan-Alvarez V, Garcia-Gonzalez E, Garcia-Perez G, Santana A, Martin-Rincon M, Calbet JAL
Free radical biology & medicine 2024 Nov 1;224:182-189

Cardiac-specific overexpression of CREM-IbΔC-X via CRISPR/Cas9 in mice presents a new model of atrial cardiomyopathy with spontaneous atrial fibrillation.

Chen J, Qin H, Hao J, Wang Q, Chen S, Yang G, Li M, Zhu X, Wang D, Chen H, Cui C, Chen M
Translational research : the journal of laboratory and clinical medicine 2024 May;267:54-66

Near-Infrared II Fluorescence Imaging and Image-Guided siRNA Therapy of Atherosclerosis.

Gao J, Yu K, Luo Q, Deng M, Hou X, Wang W, Zeng X, Xiong X, He Y, Hong X, Xiao Y
Journal of medicinal chemistry 2024 Jul 25;67(14):12428-12438

Intranasal Delivery of Near-Infrared and Magnetic Dual-Response Nanospheres to Rapidly Produce Antidepressant-Like and Cognitive Enhancement Effects.

Hu J, Lian Z, Weng Z, Xu Z, Gao J, Liu Y, Luo T, Wang X
Advanced materials (Deerfield Beach, Fla.) 2024 Aug;36(31):e2405547

In vitro and in vivo inhibition of the host TRPC4 channel attenuates Zika virus infection.

Chen X, Yan Y, Liu Z, Yang S, Li W, Wang Z, Wang M, Guo J, Li Z, Zhu W, Yang J, Yin J, Dai Q, Li Y, Wang C, Zhao L, Yang X, Guo X, Leng L, Xu J, Obukhov AG, Cao R, Zhong W
EMBO molecular medicine 2024 Aug;16(8):1817-1839

The delta subunit of the GABA(A) receptor is necessary for the GPT2-promoted breast cancer metastasis.

Li N, Xu X, Liu D, Gao J, Gao Y, Wu X, Sheng H, Li Q, Mi J
Theranostics 2023;13(4):1355-1369

The novel peptide athycaltide-1 attenuates Ang II-induced pathological myocardial hypertrophy by reducing ROS and inhibiting the activation of CaMKII and ERK1/2.

Zheng X, Su F, Lei M, Li J, Zhang C, Zhang Y, Wei M, Li W, Chen S, Liu Y, Gao Q, Hao L
European journal of pharmacology 2023 Oct 15;957:175969

Immunohistochemical distribution of Ca(2+)/calmodulin-dependent protein kinase II subunits in the rat carotid body.

Saito H, Yokoyama T, Nakamuta N, Yamamoto Y
Acta histochemica 2023 May;125(4):152043

Orally administered sodium nitrite prevents the increased α-1 adrenergic vasoconstriction induced by hypertension and promotes the S-nitrosylation of calcium/calmodulin-dependent protein kinase II.

Oliveira-Paula GH, I M Batista R, Stransky S, Tella SC, Ferreira GC, Portella RL, Pinheiro LC, Damacena-Angelis C, Riascos-Bernal DF, Sidoli S, Sibinga N, Tanus-Santos JE
Biochemical pharmacology 2023 Jun;212:115571

Evaluation of the synergistic effects of epigallocatechin-3-gallate-loaded PEGylated-PLGA nanoparticles with nimodipine against neuronal injury after subarachnoid hemorrhage.

Yang X, Han M, Wang X, Wang J, Sun X, Zhang C, Yan S, Huang L, Chen Y
Frontiers in nutrition 2022;9:953326

Wnt5a protects motor neurons in amyotrophic lateral sclerosis by regulating the Wnt/Ca(2+) signaling pathway.

Liu J, Zhou F, Chen Y, Guan Y, Meng F, Zhao Z, Wang X, Gao X, Jiang X, Zhang H, Wang Q, Zhou S, Wang X
American journal of translational research 2022;14(8):5343-5362

Loss of phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (Pip5k1c) in mesenchymal stem cells leads to osteopenia by impairing bone remodeling.

Yan Q, Gao H, Yao Q, Ling K, Xiao G
The Journal of biological chemistry 2022 Mar;298(3):101639

Protein C receptor maintains cancer stem cell properties via activating lipid synthesis in nasopharyngeal carcinoma.

Zhang P, He Q, Wang Y, Zhou G, Chen Y, Tang L, Zhang Y, Hong X, Mao Y, He Q, Yang X, Liu N, Ma J
Signal transduction and targeted therapy 2022 Feb 16;7(1):46

Azoramide ameliorated tachypacing-induced injury of atrial myocytes differentiated from human induced pluripotent stem cell by regulating endoplasmic reticulum stress.

Miao W, Shi J, Huang J, Lin Y, Cui C, Zhu Y, Zheng B, Li M, Jiang Q, Chen M
Stem cell research 2022 Apr;60:102686

TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca(2+)/CaMKII/Nrf2 signaling pathway.

Lv Z, Xu X, Sun Z, Yang YX, Guo H, Li J, Sun K, Wu R, Xu J, Jiang Q, Ikegawa S, Shi D
Cell death & disease 2021 May 18;12(6):504

RIP3 facilitates necroptosis through CaMKII and AIF after intracerebral hemorrhage in mice.

Xu Y, Wu X, Hu W, Yu D, Shao Z, Li W, Huang T, Zhang J, Zhu X, Li X, Yang H, Chu Z, Lv K
Neuroscience letters 2021 Apr 1;749:135699

Wnt5a-induced M2 polarization of tumor-associated macrophages via IL-10 promotes colorectal cancer progression.

Liu Q, Yang C, Wang S, Shi D, Wei C, Song J, Lin X, Dou R, Bai J, Xiang Z, Huang S, Liu K, Xiong B
Cell communication and signaling : CCS 2020 Mar 30;18(1):51

CAMKIIγ is a targetable driver of multiple myeloma through CaMKIIγ/ Stat3 axis.

Yang L, Wu B, Wu Z, Xu Y, Wang P, Li M, Xu R, Liang Y
Aging 2020 Jul 13;12(13):13668-13683

Pin1 Is Regulated by CaMKII Activation in Glutamate-Induced Retinal Neuronal Regulated Necrosis.

Wang S, Liao L, Huang Y, Wang M, Zhou H, Chen D, Liu F, Ji D, Xia X, Jiang B, Huang J, Xiong K
Frontiers in cellular neuroscience 2019;13:276

PIWIL1 destabilizes microtubule by suppressing phosphorylation at Ser16 and RLIM-mediated degradation of Stathmin1.

Li C, Zhou X, Chen J, Lu Y, Sun Q, Tao D, Hu W, Zheng X, Bian S, Liu Y, Ma Y
Oncotarget 2015 Sep 29;6(29):27794-804

JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse.

Berg JM, Lee C, Chen L, Galvan L, Cepeda C, Chen JY, Peñagarikano O, Stein JL, Li A, Oguro-Ando A, Miller JA, Vashisht AA, Starks ME, Kite EP, Tam E, Gdalyahu A, Al-Sharif NB, Burkett ZD, White SA, Fears SC, Levine MS, Wohlschlegel JA, Geschwind DH
Neuron 2015 Dec 16;88(6):1173-1191

iTRAQ-based proteomic analysis of dioscin on human HCT-116 colon cancer cells.

Chen H, Xu L, Yin L, Xu Y, Han X, Qi Y, Zhao Y, Liu K, Peng J
Proteomics 2014 Jan;14(1):51-73

Calmodulin-dependent protein kinase gamma 3 (CamKIIgamma3) mediates the cell cycle resumption of metaphase II eggs in mouse.

Chang HY, Minahan K, Merriman JA, Jones KT
Development (Cambridge, England) 2009 Dec;136(24):4077-81

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: SMMC-7721 cells were subjected to SDS PAGE followed by western blot with 12666-2-AP( CAMK2G Antibody) at dilution of 1:2000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using CAMK2G antibody 12666-2-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human pancreas cancer using 12666-2-AP(CAMK2G antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue