21933-1-AP

antibody from Proteintech Group

Targeting: SOST DAND6, VBCH

Provider product page for 21933-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [24]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

Submit

Product number: 21933-1-AP - Provider product page
Provider: Proteintech Group
Product name: Sclerostin antibody
Antibody type: Polyclonal
Description: Sclerostin antibody (Cat. #21933-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SOST protein structure - 21933-1-AP shown in red.

Submitted references WISP2 Overexpression Is Associated with Reduced Vasculogenic Mimicry and Epithelial-Mesenchymal Transition in Gastric Cancer.

Xu X, Chen Y, Zhang L, Pan P, Duan T, Cheng Z, Lu G
Digestive diseases and sciences 2026 Mar 8;

Tumor Radiotherapy-Induced Sympathetic Hyperactivation Orchestrates Rapid Systemic Bone Loss.

Wang C, Kuang S, Sun L, Li Y, Wang G, Sun J, Zhou F, Zhang C
Calcified tissue international 2026 Mar 31;117(1)

Effect of moderate-intensity treadmill exercise on bone quality in adult rats and the underlying mechanisms.

Li C, Gong H, Cen H, Wu X, Wang L, Fan Y
BMC musculoskeletal disorders 2026 Jan 19;27(1):136

Activation of sclerostin inhibits Isg20-Mediated aerobic glycolysis ameliorating renal Fibrosis: the renoprotective mechanism of hederagenin in CKD.

Han RY, Tan RZ, Xu LH, Lin JY, Li T, Su HW, Li P, Liu P, Lan HY, Wang L
Redox biology 2025 Sep;85:103762

Self-assembled extracellular matrix-lipid nanoparticle composite for site-specific siRNA delivery to improve cardiac repair post-myocardial infarction.

Wang X, Zhong Y, Qian B, Huang S, Long Q, Zhang H, Zhao Q, Ye X
Materials today. Bio 2025 Oct;34:102205

P62 acts as an intermediator in cadmium-induced osteocyte apoptosis and osteoporosis in mice.

Yu F, Liu L, Ali W, Ma Y, Song R, Zhao H, Zou H, Bian J, Yuan Y, Gu J, Tong X, Liu Z
Biochemical pharmacology 2025 Oct;240:117104

Capture the superior anti-osteoporotic innovative multi-component complex from Ligustri Lucidi Fructus based on Component Recombination strategy.

Jiang J, Zhao B, Ma Y, Zeng Y, Zeng Y, Fang J, Kang W, Chen T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157116

Hyperbaric oxygen potentiates platelet-rich plasma composition and accelerates bone healing.

Chang WS, Huang CC, Chen TH, Chao SH, Lin CH, Chang CP, Chien CS
Journal of orthopaedic translation 2025 Mar;51:1-12

Effects of recombinant human sclerostin on proliferation and migration in human cementoblast lineage cells.

Okimura N, Kunimatsu R, Kado I, Nakatani A, Sakata S, Ikeda K, Ito S, Ogasawara T, Ogashira S, Miyauchi M, Takata T, Tanimoto K
Archives of oral biology 2025 Jul;175:106273

An RNA G-quadruplex within the sclerostin 3' untranslated region enhances sclerostin expression by blocking miR-4648 binding.

Duan X, Luo J, Hong Z, Song Z, Chen Z, Song D, Wang S, Chen XC, Lu YJ, Jin F
International journal of biological macromolecules 2025 Aug;319(Pt 1):145405

Colchicine Blocks Abdominal Aortic Aneurysm Development by Maintaining Vascular Smooth Muscle Cell Homeostasis.

Chen M, Yang D, Zhou Y, Yang C, Lin W, Li J, Liu J, Ye J, Huang W, Ma W, Li W, Chen J, Zhang Y, Shi GP, Luo J, Li J, Luo S
International journal of biological sciences 2024;20(6):2092-2110

An integrated multi-omics analysis reveals osteokines involved in global regulation.

Liang W, Wei T, Hu L, Chen M, Tong L, Zhou W, Duan X, Zhao X, Zhou W, Jiang Q, Xiao G, Zou W, Chen D, Zou Z, Bai X
Cell metabolism 2024 May 7;36(5):1144-1163.e7

Hydroxyapatite Nanoparticles Promote the Development of Bone Microtissues for Accelerated Bone Regeneration by Activating the FAK/Akt Pathway.

Li L, Li H, Wang Q, Xue Y, Dai Y, Dong Y, Shao M, Lyu F
ACS biomaterials science & engineering 2024 Jul 8;10(7):4463-4479

Oligomeric Proanthocyanidins Ameliorate Cadmium-Induced Senescence of Osteocytes Through Combating Oxidative Stress and Inflammation.

Yu G, Wang Z, Gong A, Fu X, Chen N, Zhou D, Li Y, Liu Z, Tong X
Antioxidants (Basel, Switzerland) 2024 Dec 12;13(12)

Low bone turnover is associated with advanced glycation end-products, oxidative stress, and inflammation induced by type 2 diabetes mellitus.

Shi P, Gong H, Lyu L, Liu S, Jia S, Li C, Wu X, Li X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Aug 15;38(15):e23871

Notch1 is a marker for in situ resting osteocytes in a 3-dimensional gel culture model.

Zhou YH, Zhu JY, Guo Y, Tang HN, Wang F, Iqbal J, Wu HX, Hu N, Xiao F, Wang T, Li L, Zhou HD
Connective tissue research 2023 Sep;64(5):491-504

Lysyl oxidase inhibits BMP9-induced osteoblastic differentiation through reducing Wnt/β-catenin via HIF-1a repression in 3T3-L1 cells.

Zhang J, Ye F, Ye A, He B
Journal of orthopaedic surgery and research 2023 Nov 29;18(1):911

Inhibition of RANKL Expression in Osteocyte-like Differentiated Tumor Cells in Giant Cell Tumor of Bone After Denosumab Treatment.

Noguchi T, Sakamoto A, Murotani Y, Murata K, Hirata M, Yamada Y, Toguchida J, Matsuda S
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2023 Mar;71(3):131-138

Sclerostin Suppression Facilitates Uveal Melanoma Progression Through Activating Wnt/β-Catenin Signaling Via Binding to Membrane Receptors LRP5/LRP6.

Wang H, Zhao S, Liu Y, Sun F, Huang X, Wu T
Frontiers in oncology 2022;12:898047

Sigma-1 receptor attenuates osteoclastogenesis by promoting ER-associated degradation of SERCA2.

Wei X, Zheng Z, Feng Z, Zheng L, Tao S, Zheng B, Huang B, Zhang X, Liu J, Chen Y, Zong W, Shan Z, Fan S, Chen J, Zhao F
EMBO molecular medicine 2022 Jul 7;14(7):e15373

Mechanisms of sphingosine-1-phosphate (S1P) signaling on excessive stress-induced root resorption during orthodontic molar intrusion.

Wang H, Li T, Wang X, Guan Y, Jiang Y, Chen S, Zou S, Duan P
Clinical oral investigations 2022 Jan;26(1):1003-1016

The role of EphB4/ephrinB2 signaling in root repair after orthodontically-induced root resorption.

Li T, Wang H, Liu R, Wang X, Huang L, Wu Z, Yin X, Zou S, Duan P
American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics 2021 Mar;159(3):e217-e232

Cyclooxygenase-2/sclerostin mediates TGF-β1-induced calcification in vascular smooth muscle cells and rats undergoing renal failure.

He F, Li L, Li PP, Deng Y, Yang YY, Deng YX, Luo HH, Yao XT, Su YX, Gan H, He BC
Aging 2020 Nov 6;12(21):21220-21235

Higher Sclerostin/SOST expression is associated with lower percentage of circulatory blasts and better prognosis in patients with myelofibrosis.

Lucijanic M, Livun A, Tupek KM, Stoos-Veic T, Pejsa V, Kusec R
Annals of hematology 2018 Jul;97(7):1293-1294

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with 21933-1-AP( SOST Antibody) at dilution of 1:1000
Other comments: WB
Appendix: 21933-1-AP.pdf

: Show more

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The SOST antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human SOST. This antibody recognizes human antigen. The SOST antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 21933-1-AP.pdf

: Show more

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemistry of paraffin-embedded human liver tissue slide using 21933-1-AP( SOST Antibody) at dilution of 1:50 (under 10x lens)
Other comments: IHC
Appendix: 21933-1-AP.pdf

: Show more