Explore
Validate
Learn
Western blotAntibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- PAB4841 - Provider product page
- Provider
- Abnova Corporation
- Proper citation
- Abnova Corporation Cat#PAB4841, RRID:AB_1580902
- Product name
- SOST polyclonal antibody
- Antibody type
- Polyclonal
- Description
- Rabbit polyclonal antibody raised against synthetic peptide of SOST.
- Storage
- Store at 4°C. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
Submitted references Human genetics of SOST.
Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity.
LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST.
Balemans W, Van Hul W
Journal of musculoskeletal & neuronal interactions 2006 Oct-Dec;6(4):355-6
Journal of musculoskeletal & neuronal interactions 2006 Oct-Dec;6(4):355-6
Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity.
Ellies DL, Viviano B, McCarthy J, Rey JP, Itasaki N, Saunders S, Krumlauf R
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006 Nov;21(11):1738-49
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006 Nov;21(11):1738-49
LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST.
Semenov MV, He X
The Journal of biological chemistry 2006 Dec 15;281(50):38276-84
The Journal of biological chemistry 2006 Dec 15;281(50):38276-84
No comments: Submit comment
Supportive validation
- Submitted by
- Abnova Corporation (provider)
- Main image
- Experimental details
- Western blot analysis of SOST polyclonal antibody (Cat # PAB4841) in mouse liver tissue lysate (35 ug/lane). SOST (arrow) was detected using the purified polyclonal antibody (1 : 60 dilution).
Supportive validation
- Submitted by
- Abnova Corporation (provider)
- Main image
- Experimental details
- Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with SOST polyclonal antibody (Cat # PAB4841) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated.
- Validation comment
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
