Antibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- PAB4127 - Provider product page
- Provider
- Abnova Corporation
- Proper citation
- Abnova Corporation Cat#PAB4127, RRID:AB_1574510
- Product name
- DUSP3 polyclonal antibody
- Antibody type
- Polyclonal
- Description
- Rabbit polyclonal antibody raised against synthetic peptide of DUSP3.
- Storage
- Store at 4°C. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
Submitted references Tyrosine phosphorylation of VHR phosphatase by ZAP-70.
Inhibitory role for dual specificity phosphatase VHR in T cell antigen receptor and CD28-induced Erk and Jnk activation.
Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway.
Alonso A, Rahmouni S, Williams S, van Stipdonk M, Jaroszewski L, Godzik A, Abraham RT, Schoenberger SP, Mustelin T
Nature immunology 2003 Jan;4(1):44-8
Nature immunology 2003 Jan;4(1):44-8
Inhibitory role for dual specificity phosphatase VHR in T cell antigen receptor and CD28-induced Erk and Jnk activation.
Alonso A, Saxena M, Williams S, Mustelin T
The Journal of biological chemistry 2001 Feb 16;276(7):4766-71
The Journal of biological chemistry 2001 Feb 16;276(7):4766-71
Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway.
Todd JL, Tanner KG, Denu JM
The Journal of biological chemistry 1999 May 7;274(19):13271-80
The Journal of biological chemistry 1999 May 7;274(19):13271-80
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Supportive validation
- Submitted by
- Abnova Corporation (provider)
- Main image
- Experimental details
- Western blot analysis of DUSP3 (arrow) using DUSP3 polyclonal antibody (Cat # PAB4127).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the DUSP3 gene (Lane 2).
Supportive validation
- Submitted by
- Abnova Corporation (provider)
- Main image
- Experimental details
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with DUSP3 polyclonal antibody (Cat # PAB4127) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Validation comment
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)